Review
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Pascalle Mossel, Anna L. Bartels, Rudi A. J. O. Dierckx, Gert Luurtsema, Adriaan A. Lammertsma, Antoon T. M. Willemsen, Erik F. J. de Vries
Summary: Pharmacokinetic modelling with arterial sampling is the gold standard for analyzing dynamic PET data of the brain, but it has limited clinical application due to its invasive nature. Non-invasive methods, such as population based input function (PBIF), image derived input function (IDIF), and simultaneous estimation of the input function (SIME), have been proposed as alternatives. This systematic review assesses the correspondence of these non-invasive methods with the gold standard and highlights the need for validation before clinical implementation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Engineering, Biomedical
Xueqi Chen, Sulei Zhang, Jianhua Zhang, Lixin Chen, Rongfu Wang, Yun Zhou
Summary: The study evaluates an optimization approach based on Patlak plot with reduced blood samples for noninvasive quantification of dynamic F-18-FDG PET imaging. The results show that the method is reliable and can potentially be extended to further translational human studies.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Neurosciences
Chris W. J. van der Weijden, Anouk van der Hoorn, Yanming Wang, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Erik F. J. de Vries
Summary: Multiple sclerosis (MS) is an inflammatory demyelinating disease, and new treatment strategies are needed to prevent myelin damage and promote remyelination. The study showed that image-derived input functions can be used as a quantitative method for [11C]MeDAS PET, but individual arterial input functions are necessary for unbiased quantification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Songye Li, Mika Naganawa, Richard Pracitto, Soheila Najafzadeh, Daniel Holden, Shannan Henry, David Matuskey, Paul R. Emery, Zhengxin Cai, Jim Ropchan, Nabeel Nabulsi, Richard E. Carson, Yiyun Huang
Summary: The study demonstrated that [F-18]SynVesT-1 has excellent imaging and binding properties in humans, with fast and high brain uptake, appropriate tissue kinetics, high levels of specific binding, and excellent test-retest reproducibility. Therefore, [F-18]SynVesT-1 is proven to be a favorable radiotracer for SV2A imaging and quantification in humans.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Fengyun Gu, Qi Wu
Summary: Positron emission tomography (PET) scanning is an important diagnostic imaging technique used in disease diagnosis, therapy planning, treatment monitoring, and medical research. Dynamic PET scans can provide detailed metabolic information beyond static measures, but there are challenges in dealing with large-scale data size and organ-specific physiology.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yannick Bliesener, R. Marc Lebel, Jay Acharya, Richard Frayne, Krishna S. Nayak
Summary: This study demonstrated a fully automated high-resolution whole-brain DCE MRI pipeline with 30-fold sparse undersampling and estimated its reproducibility on the basis of reference regions of stable tissue types in patients with high-grade glioma. Results showed that in healthy tissues, the MRI protocol estimated a reproducibility coefficient for median K-trans below 0.06 min(1) in large, low-enhancing tissue regions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shulin Yao, Tao Feng, Yizhang Zhao, Runze Wu, Ruimin Wang, Shina Wu, Can Li, Baixuan Xu
Summary: Parametric imaging using the Patlak model has been shown to improve lesion detectability and specificity. A simplified scanning protocol that combines population-based and model-based input functions was proposed, with errors in the population-based function only affecting the global scale of the Patlak images. The quantitative impact can be predicted using proposed formulas.
Article
Clinical Neurology
Jeong-Hee Kim, Yo-Han Joo, Young-Don Son, Hang-Keun Kim, Jong-Hoon Kim
Summary: This study found a significant relationship between social avoidance levels and mGluR5 availability in the frontal cortex of drug-naive patients with major depressive disorder (MDD), suggesting that social avoidance should be considered as a clinical factor involved in mGluR5 signaling changes in depression.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Psychiatry
Anne-Claire Dupont, Sophie Serriere, Laurent Barantin, Johnny Vercouillie, Clovis Tauber, Valerie Gissot, Sylvie Bodard, Gabrielle Chicheri, Sylvie Chalon, Pr Frederique Bonnet-Brilhault, Pr Maria-Joao Santiago-Ribeiro, Nicolas Arlicot
Summary: PET imaging studies showed that the binding of [F-18]FPEB to mGluR5 in healthy subjects is not modulated by endogenous glutamate and unable to measure acute fluctuations in endogenous levels of glutamate.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Aylin Rosberg, Jetro J. Tuulari, Venla Kumpulainen, Minna Lukkarinen, Elmo P. Pulli, Eero Silver, Anni Copeland, Ekaterina Saukko, Jani Saunavaara, John D. Lewis, Linnea Karlsson, Hasse Karlsson, Harri Merisaari
Summary: This study investigated the intrascan test-retest repeatability of four DTI scalars in 5-year-old children, with results showing good to excellent reliability for most ROIs and low variability overall. In voxelwise analysis, FA and RD had higher reliability compared to AD and MD, with low variability across all scalars.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nancy A. Obuchowski, Andrew J. Buckler
Summary: The repeatability of quantitative imaging biomarkers is a critical performance metric. This study presents a method for estimating repeatability without a test-retest study and evaluates its performance through a simulation study.
ACADEMIC RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rongmei Tang, Yongkang Gai, Kun Li, Fan Hu, Chengpeng Gong, Sheng Wang, Fei Feng, Bouhari Altine, Jia Hu, Xiaoli Lan
Summary: A novel carbon-11 radiolabeled molecular probe C-11-methoxy-OTSSP167 was successfully synthesized and exhibited elevated uptake in MELK overexpressed tumors, showing potential for noninvasive imaging of TNBC. This tracer had high radiochemical purity and specifically targeted triple-negative breast cancers.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jiang Zhang, Xinzhi Teng, Xinyu Zhang, Sai-Kit Lam, Zhongshi Lin, Yongyi Liang, Hao Yu, Steven Wai Kwan Siu, Amy Tien Yee Chang, Hua Zhang, Feng-Ming Kong, Ruijie Yang, Jing Cai
Summary: This study compared the impact of repeatable features determined by two methods on the reliability of radiomic models. The findings suggest that image perturbation can achieve similar reliability to test-retest imaging under specific conditions. However, careful consideration is needed when determining the optimal feature repeatability criteria.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Jens Mincke, Jan Courtyn, Christian Vanhove, Stefaan Vandenberghe, Kathy Steppe
Summary: PET, with its high sensitivity and specificity for tumor detection, has become a standard and widely used molecular imaging technique. Despite the limited number of research groups worldwide conducting PET-based studies in plants, there is significant untapped potential for this technique to contribute extensively to plant science. The complexity of integrating methodological developments from multiple disciplines may be a barrier for some research groups, but with clear guidance on designing and executing PET scans, processing data, and using compartmental modeling, researchers are encouraged to explore the full potential of PET in studying plant dynamics, particularly carbon dynamics using (CO2)-C-11 tracing.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Oncology
Matteo Donadon, Egesta Lopci, Jacopo Galvanin, Simone Giudici, Daniele Del Fabbro, Ezio Lanza, Vittorio Pedicini, Arturo Chiti, Guido Torzilli
Summary: The study investigates the clinical impact of C-11-choline positron emission tomography/computed tomography (PET/CT) in hepatocellular carcinoma (HCC) patients undergoing hepatectomy. Results show that Barcelona stages and metabolic tumor volume (MTV) are independently associated with overall survival. Incorporating C-11-choline PET/CT into the HCC staging system may provide better prognostic refinement.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Jeroen Verhaeghe, Leonie Wyffels, Alan Miranda, Sigrid Stroobants, Ladislav Mrzljak, Celia Dominguez, Mette Skinbjerg, Jonathan Bard, Longbin Liu, Ignacio Munoz-Sanjuan, Steven Staelens
Summary: This study used C-11-UCB-J PET imaging to detect SV2A deficits in the brains and spinal cords of symptomatic HD mice, suggesting it could be a novel marker of synaptic integrity.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Jeroen Verhaeghe, Alan Miranda, Leonie Wyffels, Sigrid Stroobants, Ladislav Mrzljak, Vinod Khetarpal, Mette Skinbjerg, Longbin Liu, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, Steven Staelens
Summary: The study demonstrated that the novel radioligand [C-11]CHDI-626 is suitable for mHTT PET imaging. Longitudinal quantification revealed genotype differences, with an increase in signal in HET mice associated with mHTT aggregate load progression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Bertoglio, Nicolas Halloin, Stef De Lombaerde, Aleksandar Jankovski, Jeroen Verhaeghe, Charles Nicaise, Steven Staelens
Summary: This study explored the use of synaptic vesicle glycoprotein 2A (SV2A) PET imaging for noninvasively detecting spinal cord lesions after spinal cord injury (SCI). The results showed that C-11-UCB-J PET/CT imaging is a valuable tool for evaluating SCI, and SV2A PET may provide an objective measure of SCI. The use of SV2A PET imaging in clinical assessment of SCI is highly recommended.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Cell Biology
Daniele Bertoglio, Jonathan Bard, Manuela Hessmann, Longbin Liu, Annette Gaertner, Stef De Lombaerde, Britta Huscher, Franziska Zajicek, Alan Miranda, Finn Peters, Frank Herrmann, Sabine Schaertl, Tamara Vasilkovska, Christopher J. Brown, Peter D. Johnson, Michael E. Prime, Matthew R. Mills, Annemie Van der Linden, Ladislav Mrzljak, Vinod Khetarpal, Yuchuan Wang, Deanna M. Marchionini, Mette Skinbjerg, Jeroen Verhaeghe, Celia Dominguez, Steven Staelens, Ignacio Munoz-Sanjuan
Summary: This study developed a PET imaging radioligand with high affinity and selectivity for monitoring the pathological mutant HTT (mHTT) protein in the brain noninvasively. It also showed that therapeutic interventions targeting mHTT expression could lead to region- and time-dependent suppression of mHTT and functional restoration in a rodent model.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Dorien Glorie, Jeroen Verhaeghe, Alan Miranda, Stef De Lombaerde, Sigrid Stroobants, Steven Staelens
Summary: This study provides a direct comparison between two positron emission tomography radioligands targeting mGluR5 and demonstrates their common binding site and strong relationship with mGluR5 availability levels. Both radioligands successfully showed reduced mGluR5 availability in a model for compulsive-like behavior, with [C-11]ABP688 achieving higher significance levels in more brain regions.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Endocrinology & Metabolism
Daniele Bertoglio, Franziska Zajicek, Stef De Lombaerde, Alan Miranda, Sigrid Stroobants, Yuchuan Wang, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, Longbin Liu, Jeroen Verhaeghe, Steven Staelens
Summary: This study extensively characterized the novel radioligand [F-18]SynVesT-1 and demonstrated its selectivity for SV2A with optimal kinetics. It could serve as a candidate tool for quantifying CNS synaptic density non-invasively.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Alan Miranda, Daniele Bertoglio, Sigrid Stroobants, Steven Staelens, Jeroen Verhaeghe
Summary: The linear parametric neurotransmitter positron emission tomography (lp-ntPET) kinetic model can be used to detect transient changes (activation) in endogenous neurotransmitter levels. Preclinical PET scans in awake animals can be performed to investigate neurotransmitter transient changes. Here we use the spatiotemporal kernel reconstruction (Kernel) for noise reduction in dynamic PET, and lp-ntPET kinetic modeling.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Banafshe Shafieizargar, Ben Jeurissen, Dirk H. J. Poot, Stefan Klein, Johan Van Audekerke, Marleen Verhoye, Arnold J. den Dekker, Jan Sijbers
Summary: This article introduces a novel imaging and parameter estimation framework for accurate multi-shot diffusion MRI. The proposed framework, called ADEPT, enables fast diffusion MRI by allowing diffusion contrast settings to change between shots in a multi-shot EPI acquisition. ADEPT estimates diffusion parameter maps directly from the acquired k-space data and simultaneously accounts for shot-to-shot phase inconsistencies. Simulation and real-data experiments demonstrate that ADEPT provides more accurate and precise estimates of diffusion metrics compared to reference methods.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Alison R. Weiss, Daniele Bertoglio, William A. Liguore, Kristin Brandon, John Templon, Jeanne Link, Jodi L. McBride
Summary: This study investigates alterations in dopamine receptor density and glucose utilization in a newly developed AAV-mediated NHP model of Huntington's disease (HD). The results show significantly reduced dopamine receptor densities and glucose hypometabolism in HD macaques compared to controls. PET imaging with [F-18]fallypride and [F-18]FDG can serve as noninvasive outcome measures for therapeutic studies with this HD macaque model.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Jordy Akkermans, Franziska Zajicek, Alan Miranda, Mohit H. Adhikari, Daniele Bertoglio
Summary: This study validated the use of independent component analysis (ICA) on SV2A PET data acquired with [C-11]UCB-J for the identification of cerebral pre-synaptic density networks (pSDNs) in mice in a rigorous and reproducible manner. Additionally, we found that different pSDNs change with age and are affected in a disease condition.
Article
Endocrinology & Metabolism
Alan Miranda, Daniele Bertoglio, Caro De Weerdt, Steven Staelens, Jeroen Verhaeghe
Summary: This study investigated the impact of isoflurane and ketamine-xylazine anesthesia on [F-18]SynVesT-1 PET tracer in the mouse brain. Different anesthesia conditions were compared, and the effects of levetiracetam were also assessed. The results showed significant differences in tracer kinetics and volume of distribution between anesthesia conditions and awake conditions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Meeting Abstract
Endocrinology & Metabolism
F. Zajicek, J. Verhaeghe, S. De Lombaerde, A. Miranda, S. Stroobants, M. Skinbjerg, Y. Wang, I. Munoz-Sanjuan, C. Dominguez, V. Khetarpal, J. Bard, L. Liu, D. Bertoglio, S. Staelens
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)