Article
Endocrinology & Metabolism
Manabu Kubota, Yasuyuki Kimura, Masafumi Shimojo, Yuhei Takado, Joao M. N. Duarte, Hiroyuki Takuwa, Chie Seki, Hitoshi Shimada, Hitoshi Shinotoh, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Kenji Tagai, Takayuki Obata, Jin Nakahara, Yutaka Tomita, Masaki Tokunaga, Jun Maeda, Kazunori Kawamura, Ming-Rong Zhang, Masanori Ichise, Tetsuya Suhara, Makoto Higuchi
Summary: The study demonstrates that food intake and changes in plasma glucose levels dynamically alter metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in the human brain. These findings suggest a mechanistic link between food-associated glucose intake and glutamatergic tones in the brain, which can be accessed in vivo by bimodal PET and MRS techniques in both clinical and non-clinical settings.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yong Du, Jennifer M. Coughlin, Alireza Amindarolzarbi, Shannon Eileen Sweeney, Courtney K. Harrington, Mary Katherine Brosnan, Adeline Zandi, Laura K. Shinehouse, Alejandra N. Reyes Sanchez, Rehab Abdallah, Daniel P. Holt, Hong Fan, Wojciech G. Lesniak, Ayon Nandi, Steven P. Rowe, Lilja B. Solnes, Robert F. Dannals, Andrew G. Horti, Martin A. Lodge, Martin G. Pomper
Summary: This study reported the test-retest repeatability of [F-18]FNDP brain PET binding and [F-18]FNDP whole-body dosimetry in healthy individuals. The results showed that [F-18]FNDP brain PET imaging and whole-body dosimetry had favorable repeatability in healthy individuals.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Shofiul Azam, Md. Jakaria, JoonSoo Kim, Jaeyong Ahn, In-Su Kim, Dong-Kug Choi
Summary: Metabotropic glutamate receptors (mGluRs), especially mGluR5, play important roles in neurodegenerative diseases and neuropsychiatric disorders. Recent research suggests that mGluR5 radioligands could be used to assess disease progression and track drug properties.
Article
Radiology, Nuclear Medicine & Medical Imaging
Songye Li, Mika Naganawa, Richard Pracitto, Soheila Najafzadeh, Daniel Holden, Shannan Henry, David Matuskey, Paul R. Emery, Zhengxin Cai, Jim Ropchan, Nabeel Nabulsi, Richard E. Carson, Yiyun Huang
Summary: The study demonstrated that [F-18]SynVesT-1 has excellent imaging and binding properties in humans, with fast and high brain uptake, appropriate tissue kinetics, high levels of specific binding, and excellent test-retest reproducibility. Therefore, [F-18]SynVesT-1 is proven to be a favorable radiotracer for SV2A imaging and quantification in humans.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan H. Ruschoff, Daniela A. Ferraro, Urs J. Muehlematter, Riccardo Laudicella, Thomas Hermanns, Ann-Katrin Rodewald, Holger Moch, Daniel Eberli, Irene A. Burger, Niels J. Rupp
Summary: The study identified parameters such as PSMA(%neg), infiltrative growth pattern, smaller tumor size, and WHO/ISUP grade group 2 as being associated with lower Ga-68-PSMA-11 uptake in prostate cancer. These findings could serve as the basis for future biopsy-based biomarker development for achieving personalized, tumor-tailored imaging approaches.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
J. olde Heuvel, B. J. de Wit-van der Veen, M. Sinaasappel, C. H. Slump, M. P. M. Stokkel
Summary: Dynamic Ga-68-PSMA-11 PET/CT scans with a four-week time interval showed reproducibility with a 10% variation in uptake in primary prostate tumors. The uptake of the iliac artery and gluteal muscle reached a plateau within 5 minutes post-injection. Larger tumor volumes were associated with continued tumor uptake.
Article
Endocrinology & Metabolism
Gengyang Yuan, Maeva Dhaynaut, Nicolas J. Guehl, Ramesh Neelamegam, Sung-Hyun Moon, Xiying Qu, Pekka Poutiainen, Sepideh Afshar, Georges El Fakhri, Marc D. Normandin, Anna-Liisa Brownell
Summary: This study investigated the positive allosteric modulation of mGluR2 using in vivo PET imaging and in vitro experiments. The results showed that mG2P001 cooperatively binds with glutamate, enhancing its binding affinity in cells expressing mGluR2. Additionally, in vivo PET imaging demonstrated that [C-11]mG2P001 is a highly specific imaging ligand for mGluR2. Overall, these studies reveal that [C-11]mG2P001 is a sensitive biomarker for mGluR2 expression, and its binding is influenced by tissue glutamate concentration.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Jeong-Hee Kim, Yo-Han Joo, Young-Don Son, Hang-Keun Kim, Jong-Hoon Kim
Summary: This study found a significant relationship between social avoidance levels and mGluR5 availability in the frontal cortex of drug-naive patients with major depressive disorder (MDD), suggesting that social avoidance should be considered as a clinical factor involved in mGluR5 signaling changes in depression.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Yuko Koshimori, Michael D. Cusimano, Erica L. Vieira, Pablo M. Rusjan, Stephen J. Kish, Neil Vasdev, Sho Moriguchi, Isabelle Boileau, Thomas Chao, Zahra Nasser, M. Ishrat Husain, Khunsa Faiz, Joeffre Braga, Jeffrey H. Meyer
Summary: Traumatic brain injury (TBI) is common, but the reason behind persisting symptoms in some patients is unknown. Astrogliosis, a response to brain injury, may be a potential therapeutic target, but its presence in TBI patients with persistent symptoms has not been confirmed.
Article
Chemistry, Medicinal
James J. J. Perkins, Paul McQuade, Christopher J. J. Bungard, Tracy L. L. Diamond, Liza T. T. Gantert, Anthony L. L. Gotter, Barbara Hanney, Ivory D. D. Hills, Danielle M. M. Hurzy, Aniket Joshi, Jonathan T. T. Kern, Kelly-Ann S. Schlegel, Jesse J. J. Manikowski, Zhaoyang Meng, Julie A. A. O'Brien, Anthony J. J. Roecker, Sean M. M. Smith, Jason M. M. Uslaner, Eric Hostetler, Robert S. S. Meissner
Summary: Modification of mGluR(2) NAM resulted in analogues with excellent binding affinity, lipophilicity, and suitable physicochemical properties for a PET tracer. [C-11]MK-8056 was synthesized and shown to have appropriate affinity, selectivity, and physicochemical properties for use as a positron emission tomography tracer for GluR(2).
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Clinical Neurology
Maria Zimmermann, Luciano Minuzzi, Arturo Aliaga Aliaga, Marie-Christine Guiot, Jeffery A. Hall, Jean-Paul Soucy, Gassan Massarweh, Salah El Mestikawy, Pedro Rosa-Neto, Eliane Kobayashi
Summary: Abnormalities in the expression of mGluR5 have been observed in the hippocampus of patients with drug-resistant mTLE. The present study demonstrated reduced receptor density in mTLE specimens compared to control hippocampi, independent of age, sex, and K-D. The findings suggest that the decreased mGluR5 availability observed in PET studies may be due to internalization or conformational changes of the receptor.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Hee Kim, Hang-Keun Kim, Young-Don Son, Jong-Hoon Kim
Summary: This study explored the relationship between 5-HT2A receptor availability and aggression traits in healthy individuals, and found significant positive correlations between 5-HT2A receptor availability and overall aggression score as well as scores on different aggression subscales in multiple brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan P. M. Souza, Fernanda C. Frasson, Maria Emilia S. Takahashi, Gislaine B. O. Duarte, Vania P. Castro, Fernando V. Pericole, Licio A. Velloso, Carmino A. De Souza, Irene Lorand-Metze, Allan O. Santos, Celso D. Ramos
Summary: The aim of this study was to compare [F-18]FDG and [Ga-68]Ga-PSMA-11 PET/CT image findings in patients with multiple myeloma (MM). The study found that both methods can detect most lesions, but half of the lesions can only be identified by one tracer, suggesting their possible complementary role in MM.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Hiroki Kato, Tatsusada Okuno, Kayako Isohashi, Toru Koda, Mikito Shimizu, Hideki Mochizuki, Yuji Nakatsuji, Jun Hatazawa
Summary: This study used quantitative PET scans to observe increased metabolism of reactive astrocytes and compromised integrity of neuronal tracts in the brains of patients with multiple sclerosis. The activation of astrocytes and the associated pathology in multiple sclerosis were visualized through quantitative 1-C-11 acetate PET imaging.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Review
Clinical Neurology
Thomas K. Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner S. Brum, Andrea L. Benedet, Laia Montoliu-Gaya, Juan Lantero-Rodriguez, Tharick Ali Pascoal, Marc Suarez-Calvet, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Summary: This article summarizes the performance of blood phosphorylated tau biomarkers in the context of Alzheimer disease (AD) and discusses the related ethical, analytical, and clinical challenges. It highlights the potential of blood biomarkers as first-line diagnostic and prognostic tools, but emphasizes the need to address outstanding ethical, clinical, and analytical challenges, and standardize inter-laboratory and inter-assay measurements.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Justine Y. Hansen, Golia Shafiei, Jacob W. Vogel, Kelly Smart, Carrie E. Bearden, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan Buitelaar, Carrie R. McDonald, Sanjay M. Sisodiya, Lianne Schmaal, Dick J. Veltman, Odile A. van den Heuvel, Dan J. Stein, Theo G. M. van Erp, Christopher R. K. Ching, Ole A. Andreassen, Tomas Hajek, Nils Opel, Gemma Modinos, Andre Aleman, Ysbrand van der Werf, Neda Jahanshad, Sophia Thomopoulos, Paul M. Thompson, Richard E. Carson, Alain Dagher, Bratislav Misic
Summary: Changes in structural and functional connectivity can lead to neurodegeneration and neurodevelopmental diseases. In this study, the authors investigate the molecular and connectomic patterns in various neurological, psychiatric, and neurodevelopmental diseases from the ENIGMA consortium. They find a relationship between molecular vulnerability, white-matter architecture, and cortical disorder profiles. Local attributes, especially neurotransmitter receptor profiles, are the best predictors of disorder-specific cortical morphology and cross-disorder similarity. Furthermore, they identify specific network epicenters involved in cross-disorder abnormalities. Overall, this study highlights the importance of local molecular attributes and global connectivity in shaping cortical abnormalities across different brain disorders.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Justine Y. Hansen, Golia Shafiei, Ross D. Markello, Kelly Smart, Sylvia M. L. Cox, Martin Norgaard, Vincent Beliveau, Yanjun Wu, Jean-Dominique Gallezot, Etienne Aumont, Stijn Servaes, Stephanie G. Scala, Jonathan M. DuBois, Gabriel Wainstein, Gleb Bezgin, Thomas Funck, Taylor W. Schmitz, R. Nathan Spreng, Marian Galovic, Matthias J. Koepp, John S. Duncan, Jonathan P. Coles, Tim D. Fryer, Franklin Aigbirhio, Colm J. McGinnity, Alexander Hammers, Jean-Paul Soucy, Sylvain Baillet, Synthia Guimond, Jarmo Hietala, Marc-Andre Bedard, Marco Leyton, Eliane Kobayashi, Pedro Rosa-Neto, Melanie Ganz, Gitte M. Knudsen, Nicola Palomero-Gallagher, James M. Shine, Richard E. Carson, Lauri Tuominen, Alain Dagher, Bratislav Misic
Summary: This study compiles an atlas of neurotransmitter receptor/transporter densities in the human cortex and shows that receptor architecture reflects brain structure, function, dynamics, cognitive specialization, and disease vulnerability. The researchers found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. They also discovered associations between receptor distributions and cortical abnormality patterns across different disorders.
NATURE NEUROSCIENCE
(2022)
Editorial Material
Cell Biology
Eduardo R. Zimmer, Tharick A. Pascoal, Pedro Rosa-Neto, Agneta Nordberg, Luc Pellerin
Summary: This statement suggests that astrocytes play a major role in the microglia-dependent modulation of FDG-PET.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biology
Kok Pin Ng, Xing Qian, Kwun Kei Ng, Fang Ji, Pedro Rosa-Neto, Serge Gauthier, Nagaendran Kandiah, Juan Helen Zhou
Summary: This study uses sparse varying coefficient modeling to reveal the differential trajectories of the relationships between structural and metabolic networks and memory across different pathologies and cognitive stages in Alzheimer's disease (AD). The findings highlight the potential for early intervention targeting network breakdown at the preclinical stage of AD.
Article
Multidisciplinary Sciences
Yasser Iturria-Medina, Quadri Adewale, Ahmed F. Khan, Simon Ducharme, Pedro Rosa-Neto, Kieran O'Donnell, Vladislav A. Petyuk, Serge Gauthier, Philip L. De Jager, John Breitner, David A. Bennett
Summary: By integrating multi-omics molecular data, we have established a personalized multilevel AD taxonomy that predicts disease severity and identifies robust molecular subtypes, explaining the clinical and pathological heterogeneity of AD.
Article
Chemistry, Medicinal
Kelly Smart, Ming-Qiang Zheng, Daniel Holden, Zachary Felchner, Li Zhang, Yanjiang Han, Jim Ropchan, Richard E. Carson, Neil Vasdev, Yiyun Huang
Summary: This study evaluated two leading GSK-3 positron emission tomography (PET) radioligands, [C-11]OCM-44 and [F-18]OCM-50, in non-human primates for potential clinical translation. Both radiotracers showed good brain uptake and target selectivity in vivo, supporting their further evaluation as radioligands for imaging GSK-3 in the brain.
Article
Clinical Neurology
Deming Jiang, Li Liu, Yu Kong, Zhongyun Chen, Pedro Rosa-Neto, Kewei Chen, Liankun Ren, Min Chu, Liyong Wu
Summary: Abnormal glymphatic function, especially in the anterior and middle regions of the brain, was found in patients with bvFTD. Regional glymphatic dysfunction may contribute to the pathogenesis of bvFTD.
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Neurosciences
Kelly Smart, Isabelle Boileau
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
Kelly Smart, Carme Uribe, Kimberly L. Desmond, Sarah L. Martin, Neil Vasdev, Antonio P. Strafella
Summary: This study aimed to evaluate a noninvasive quantification method for [F-18]SynVesT-1 in PD patients and determine the minimum scan time necessary for accurate quantification. The results showed that accurate synaptic density quantification can be performed without blood sampling and with a scan time under 90 minutes.
Article
Biochemical Research Methods
Kimberly L. Desmond, Anton Lindberg, Armando Garcia, Junchao Tong, Michael B. Harkness, Elena Dobrota, Kelly Smart, Carme Uribe, Jeffrey H. Meyer, Sylvain Houle, Antonio P. Strafella, Songye Li, Yiyun Huang, Neil Vasdev
Summary: The initial goal of conducting PET imaging studies with [F-18]SynVesT-1 was hindered by anomalous biodistribution in the first two human PET studies, which was later found to be caused by a derivative of the precursor received from the manufacturer. Therefore, the first-in-human study of a structural variant, [F-18]SDM-4MP3, was conducted.
Article
Clinical Neurology
Ricardo A. S. Lima-Filho, Andrea L. Benedet, Marco Antonio De Bastiani, Guilherme Povala, Danielle Cozachenco, Sergio T. Ferreira, Fernanda G. De Felice, Pedro Rosa-Neto, Eduardo R. Zimmer, Mychael Lourenco
Summary: Lima-Filho et al. found that cognitively unimpaired elderly individuals carrying the FNDC5 rs1746661(T) allele exhibited low brain glucose metabolism and increased amyloid deposition. FNDC5 may contribute to regional glucose metabolism in the human brain. This study suggests that FNDC5 is associated with low brain glucose metabolism in elderly individuals and may participate in the regulation of brain metabolism in regions vulnerable to Alzheimer's disease pathophysiology.
BRAIN COMMUNICATIONS
(2023)
Article
Psychology, Clinical
Martin Zack, Daniela Lobo, Candice Biback, Tim Fang, Kelly Smart, Daniel Tatone, Aditi Kalia, Daniel Digiacomo, James L. Kennedy
Summary: This study aimed to investigate the effects of gambling-specific priming manipulations and the pharmacological basis on risk-taking in a Game of Dice Task (GDT). The results showed that both gambling and AMPH increased risk-taking, with a stronger effect observed in individuals with gambling disorder. The outcomes varied with pre-treatment, and cognitive inflexibility and symptom severity moderated the effects.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Kelly Smart, MingQiang Zheng, Daniel Holden, Hanyi Fang, Zachary Felchner, Michael Kapinos, Richard Carson, Neil Vasdev, Yiyun Huang
JOURNAL OF NUCLEAR MEDICINE
(2022)
Meeting Abstract
Neurosciences
Kelly Smart, Patrick D. Skosnik, David Matuskey, Nabeel Nabulsi, Jim Ropchan, Zachary Felchner, Henry Huang, Kelly P. Cosgrove, Ansel T. Hillmer
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)