Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression

KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS

(2016) Chadi G. Abdallah et al.   DEPRESSION AND ANXIETY

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

(2016) G M I Chowdhury et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression

(2016) Jorge A. Quiroz et al.   JAMA Psychiatry

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

(2015) Chadi G. Abdallah et al.   Annual Review of Medicine

In Vivo Ketamine-Induced Changes in [ 11 C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5

(2015) Christine DeLorenzo et al.   BIOLOGICAL PSYCHIATRY

Costimulation of AMPA and Metabotropic Glutamate Receptors Underlies Phospholipase C Activation by Glutamate in Hippocampus

(2015) H.-H. Kim et al.   JOURNAL OF NEUROSCIENCE

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) Theo Vos et al.   LANCET

mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress

(2015) Sora Shin et al.   NATURE NEUROSCIENCE

Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics

(2014) Natalie Matosin et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Is the mGlu5 receptor a possible target for new antidepressant drugs?

(2014) Agnieszka Pałucha-Poniewiera et al.   Pharmacological Reports

Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond

(2013) John H. Krystal et al.   BIOLOGICAL PSYCHIATRY

Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans

(2013) N R Driesen et al.   MOLECULAR PSYCHIATRY

A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 — Estimating occupancy in the absence of a reference region

(2013) Matts Kågedal et al.   NEUROIMAGE

Binding potential of (E)-[11C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its 11C-labelled Z-isomer

(2013) Kazunori Kawamura et al.   NUCLEAR MEDICINE AND BIOLOGY

Different effects of the NMDA receptor antagonists ketamine, MK-801, and memantine on postsynaptic density transcripts and their topography: Role of Homer signaling, and implications for novel antipsychotic and pro-cognitive targets in psychosis

(2013) Andrea de Bartolomeis et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Studies of the metabotropic glutamate receptor 5 radioligand [11C]ABP688 withN-acetylcysteine challenge in rhesus monkeys

(2013) Christine M. Sandiego et al.   SYNAPSE

mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway

(2013) S H Fatemi et al.   Translational Psychiatry

Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test

(2012) Michihiko Iijima et al.   BEHAVIOURAL BRAIN RESEARCH

Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: An autoradiographic study

(2012) Tomislav Kovačević et al.   BRAIN RESEARCH BULLETIN

NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia

(2012) A. Anticevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography

(2012) F. Akkus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study

(2011) Alexandra Deschwanden et al.   AMERICAN JOURNAL OF PSYCHIATRY

Imaging Changes in Glutamate Transmission In Vivo with the Metabotropic Glutamate Receptor 5 Tracer [11C] ABP688 and N-Acetylcysteine Challenge

(2011) Nobumi Miyake et al.   BIOLOGICAL PSYCHIATRY

1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism

(2011) Golam M.I. Chowdhury et al.   BIOLOGICAL PSYCHIATRY

Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist produces anxiolytic-like effects and reverses abnormal firing activity of projection neurons in the basolateral nucleus of the amygdala in rats with bilateral 6-OHDA lesions

(2011) Li Chen et al.   BRAIN RESEARCH BULLETIN

In vivo positron emission tomography imaging with [11C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons

(2011) Christine DeLorenzo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

in vivo Variation in Metabotropic Glutamate Receptor Subtype 5 Binding Using Positron Emission Tomography and [11C]ABP688

(2011) Christine DeLorenzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quantitation of Translocator Protein Binding in Human Brain with the Novel Radioligand [18F]-FEPPA and Positron Emission Tomography

(2011) Pablo M Rusjan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Residual Symptoms in Depressed Outpatients Who Respond by 50% But Do Not Remit to Antidepressant Medication

(2011) Shawn M. McClintock et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Region and state specific glutamate downregulation in major depressive disorder: A meta-analysis of 1H-MRS findings

(2011) J.J. Luykx et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Memory for Fear Extinction Requires mGluR5-Mediated Activation of Infralimbic Neurons

(2010) Darah E. Fontanez-Nuin et al.   CEREBRAL CORTEX

Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists

(2010) John H. Krystal et al.   CNS DRUGS

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

The interactive effects of ketamine and nicotine on human cerebral blood flow

(2010) Laura M. Rowland et al.   PSYCHOPHARMACOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Kinetic Modeling of the Serotonin 5-HT1B Receptor Radioligand [11C]P943 in Humans

(2009) Jean-Dominique Gallezot et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sequenced Treatment Alternatives to Relieve Depression (STAR*D): Lessons Learned

(2009) Sidney Zisook et al.   JOURNAL OF CLINICAL PSYCHIATRY

Measurement of Striatal and Extrastriatal Dopamine Transporter Binding with High-Resolution PET and [11C]PE2I: Quantitative Modeling and Test—Retest Reproducibility

(2008) Jussi Hirvonen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY