Article
Neurosciences
Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T. Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck
Summary: Aging is associated with decreased availability of mGluR5 in the brain, primarily due to tissue loss. This reduction in mGluR5 binding may provide insight into age-related molecular changes and their relationship with brain tissue loss.
Article
Cell Biology
M. Crespo, D. A. Leon-Navarro, M. Martin
Summary: Febrile seizures in children can lead to epilepsy in adults, with glutamate playing a key role in the development of neurological disorders. In the short term after seizures, GLT-1 levels increase and glutamate concentration decreases, while mGlu(5)R levels remain unchanged. However, in the long term, an increase in mGlu(5)R levels and decreases in GLT-1 and glutamate levels are observed, associated with the development of an anxious phenotype and potentially increased vulnerability to epileptic events in adults.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Chaohong Li, Baosheng Zhao, Chenlu Zhao, Lu Huang, Yuzhen Liu
Summary: The study revealed the expression and physiological function of mGluR1 in the CB. Activation of mGluR1 inhibited the response of CB to hypoxia and prolonged the latency period of the response.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychiatry
Anne-Claire Dupont, Sophie Serriere, Laurent Barantin, Johnny Vercouillie, Clovis Tauber, Valerie Gissot, Sylvie Bodard, Gabrielle Chicheri, Sylvie Chalon, Pr Frederique Bonnet-Brilhault, Pr Maria-Joao Santiago-Ribeiro, Nicolas Arlicot
Summary: PET imaging studies showed that the binding of [F-18]FPEB to mGluR5 in healthy subjects is not modulated by endogenous glutamate and unable to measure acute fluctuations in endogenous levels of glutamate.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Ming-Kai Chen, Adam P. Mecca, Mika Naganawa, Jean-Dominique Gallezot, Takuya Toyonaga, Jayanta Mondal, Sjoerd J. Finnema, Shu-fei Lin, Ryan S. O'Dell, Julia W. McDonald, Hannah R. Michalak, Brent Vander Wyk, Nabeel B. Nabulsi, Yiyun Huang, Amy F. T. Arnsten, Christopher H. van Dyck, Richard E. Carson
Summary: We conducted a comparison study on the synaptic density and metabolism in AD and CN participants using [C-11]UCB-J PET and [F-18]FDG PET, finding a similar reduction in the medial temporal lobe but a discordant reduction in neocortical regions, with higher correlations between synaptic density and metabolism in the former.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Tommaso Volpi, Giulia Vallini, Erica Silvestri, Mattia De Francisci, Tony Durbin, Maurizio Corbetta, John J. Lee, Andrei G. Vlassenko, Manu S. Goyal, Alessandra Bertoldo
Summary: The researchers developed a new method to calculate within-individual and across-individual metabolic connectivity using dynamic PET. They found that within-individual and across-individual metabolic connectivity are different, and within-individual metabolic connectivity is more similar to functional connectivity measures.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ali K. Vibholm, Anne M. Landau, Arne Moller, Jan Jacobsen, Kim Vang, Ole L. Munk, Dariusz Orlowski, Jens C. H. Sorensen, David J. Brooks
Summary: This study demonstrates that positron emission tomography (PET) can visualize increased uptake of [F-18]GE-179 by active NMDAR-ICs, and this uptake can be blocked by the PCP antagonist S-ketamine. Electrical stimulation induces a significant increase in [F-18]GE-179 uptake at the electrode site, which can be maintained at non-stimulated levels with prior injection of S-ketamine. PET is shown to be a useful tool for visualizing in vivo activation of NMDAR-ICs.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
Ya-Nan Zhang, Jing-Kai Fan, Li Gu, Hui-Min Yang, Shu-Qin Zhan, Hong Zhang
Summary: The research demonstrated that mGluR5 inhibits alpha-synuclein-induced microglia inflammation to protect against neurotoxicity, while alpha-synuclein promotes the degradation of mGluR5 through lysosomal pathway to accelerate neuroinflammation. This novel mechanism may serve as a potential therapeutic target for Parkinson's disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Krzyczmonik, Katharina E. Grafinger, Thomas Keller, Lukas Pfeifer, Sarita Forsback, Merja Haaparanta-Solin, Veronique Gouverneur, Francisco Lopez-Picon, Olof Solin
Summary: This study presents an in-depth preclinical evaluation of [18F]FMTEB in healthy Sprague Dawley rats, demonstrating its potential as a good candidate for mapping mGluR5 in the rat brain.
NUCLEAR MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Carlos Alberto Castillo, Inmaculada Ballesteros-Yanez, David Agustin Leon-Navarro, Jose Luis Albasanz, Mairena Martin
Summary: The amyloid beta peptide plays a central role in Alzheimer's disease pathology. Exposure to A beta(25-35) in rat cortical neurons increased mGluR density and affinity, along with up-regulation of adenosine A(1)R and A(2A)R. The study highlights the possible involvement of metabotropic glutamate and adenosine receptors in the early events of AD physiopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Behavioral Sciences
Sixian Chen, Haitao Ren, Fuhong Lin, Siyuan Fan, Yuze Cao, Weili Zhao, Hongzhi Guan
Summary: This study describes the clinical and radiological characteristics of anti-metabotropic glutamate receptor 5 (mGluR5) encephalitis. The main neurological symptoms in patients with anti-mGluR5 encephalitis were cognitive impairment, psychiatric or behavior problems, seizures, sleeping disorders, decreased consciousness, and movement disorders. Brain MRI was normal in some patients and limbic lobe lesions were observed in others. A subset of patients with anti-mGluR5 encephalitis had concomitant tumors. Immunotherapy led to significant improvements in most cases.
BRAIN AND BEHAVIOR
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Elin Pauwels, Sofie Celen, Mathilde Vandamme, William Leysen, Kristof Baete, Oliver Bechter, Marie Bex, Kim Serdons, Koen Van Laere, Guy Bormans, Christophe M. Deroose
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michel Koole, Donatienne Van Weehaeghe, Kim Serdons, Marissa Herbots, Christopher Cawthorne, Sofie Celen, Frederick A. Schroeder, Jacob M. Hooker, Guy Bormans, Jan de Hoon, Janice E. Kranz, Koen Van Laere, Tonya M. Gilbert
Summary: HDAC6 is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibiting HDAC6 deacetylase activity shows beneficial effects in disease models. This study evaluated the brain binding of [F-18]EKZ-001 in healthy adults, showing that it is safe for quantifying HDAC6 expression and that males have higher HDAC6 expression compared to females.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vegard Torp Lien, Sofie Celen, Syed Nuruddin, Bala Attili, Gilles Doumont, Gaetan Van Simaeys, Guy Bormans, Jo Klaveness, Dag Erlend Olberg
Summary: Cabozantinib, a multi-kinase inhibitor, exhibits unfavorable properties as a PET imaging probe in PC3 tumor xenografted mice, including slow excretion kinetics, low tumor uptake, and high non-specific binding in tumor and heart tissue. This reflects the challenges in PET imaging of tumor specific kinase expression with Cabozantinib.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere, Michel Koole
Summary: The biodistribution and dosimetry estimates of [C-11]-UCB-J in humans, derived from whole-body PET scans, show that the method is safe and allows for multiple PET examinations in the same subject with low effective dose coefficients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Guilherme D. Kolinger, David Vallez Garcia, Talakad G. Lohith, Eric D. Hostetler, Cyrille Sur, Arie Struyk, Ronald Boellaard, Michel Koole
Summary: A DTW protocol was simulated to reduce PET/CT acquisition time, considering perfusion changes and possible protocol deviations. Results showed that DTW protocol closely approximates uninterrupted TAC(120) for quantification, with less susceptibility to perfusion changes and protocol deviations compared to SUVR estimates.
Article
Biochemistry & Molecular Biology
Jenny Ceccarini, Michel Koole, Koen Van Laere
Summary: This study provides the first evidence that the availability of CB1R in the prefrontal cortex regulates dopamine release and drug-reinforcing effects. These preliminary findings support the existence of an interaction between CB1R and dopamine receptors at the molecular and behavioral level.
Article
Engineering, Biomedical
Masoomeh Rahimpour, Jeroen Bertels, Ahmed Radwan, Henri Vandermeulen, Stefan Sunaert, Dirk Vandermeulen, Frederik Maes, Karolien Goffin, Michel Koole
Summary: In this study, we proposed a cross-modal distillation approach to enhance the performance of single-sequence CNN models for brain tumor segmentation. By leveraging multi-sequence MRI data for training, the enriched CNN model achieved better segmentation results when only single-sequence MRI data were available for inference. This method shows potential in overcoming the limitations caused by missing or limited MRI sequences in clinical scenarios.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Kaat Spoormans, Melissa Crabbe, Lara Struelens, Marijke De Saint-Hubert, Michel Koole
Summary: Targeted radionuclide therapy (TRT) has the potential for highly effective treatment, but its efficiency is dependent on the absorbed dose. Tumor control probability models can predict tumor response by considering characteristics like high LET radiation and heterogeneous radiopharmaceutical distribution.
Review
Medicine, General & Internal
Prodromos Gavriilidis, Michel Koole, Salvatore Annunziata, Felix M. Mottaghy, Roel Wierts
Summary: This literature review discusses the impact of positron range correction and denoising techniques on the image quality of Ga-68 PET. The results show that these techniques can improve image quality and achieve comparable results to F-18 PET in some cases. However, further validation in clinical studies is needed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elin Pauwels, Sofie Celen, Kristof Baete, Michel Koole, Oliver Bechter, Marie Bex, Marleen Renard, Paul M. Clement, Sander Jentjens, Kim Serdons, Koen Van Laere, Guy Bormans, Christophe M. Deroose
Summary: This study evaluated the comparison between [F-18]MFBG and [I-123]MIBG as an alternative method, and the results showed that [F-18]MFBG has good imaging characteristics and improved lesion targeting.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Medicinal
Karine Mardon, Jayendra Z. Patel, Juha R. Savinainen, Damion H. R. Stimson, Caitlin R. M. Oyagawa, Natasha L. Grimsey, Mary-anne Migotto, Grace F. M. Njiru, Brett R. Hamilton, Gary Cowin, Jari Yli-Kauhaluoma, Wim Vanduffel, Idriss Blakey, Rajiv Bhalla, Christopher Cawthorne, Sofie Celen, Guy Bormans, Kristofer J. Thurecht, Muneer Ahamed
Summary: Multimodal imaging, through PET and MALDI imaging, is used to discover and validate a new probe targeting the ABHD6 enzyme. The PET ligand [18F]JZP-MA-11 is reported to have specific uptake in ABHD6-rich tissues and major brain regions, with brain uptake confirmed in a nonhuman primate study. In vivo pharmacological response upon ABHD6 inhibition is observed using MALDI imaging. These synergistic imaging efforts hold promise for improving our understanding of ABHD6-mediated endocannabinoid metabolism in peripheral and central nervous system disorders.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Joke De Vocht, Donatienne Van Weehaeghe, Fouke Ombelet, Pegah Masrori, Nikita Lamaire, Martijn Devrome, Hilde Van Esch, Mathieu Moisse, Michel Koole, Patrick Dupont, Koen Van Laere, Philip Van Damme
Summary: This study examined the impact of ALS-causing gene mutations on cerebral glucose metabolism using genetic testing and FDG PET imaging. The results showed distinctive differences in glucose metabolism patterns between C9orf72-ALS patients and sporadic ALS patients, particularly in specific regions of the brain.
Article
Radiology, Nuclear Medicine & Medical Imaging
Masoomeh Rahimpour, Marie-Judith Saint Martin, Frederique Frouin, Pia Akl, Fanny Orlhac, Michel Koole, Caroline Malhaire
Summary: This study developed a visual ensemble selection approach using deep convolutional neural networks (CNN) for 3D segmentation of breast tumors based on T1-weighted dynamic contrast-enhanced (T1-DCE) MRI, achieving good segmentation accuracy.
EUROPEAN RADIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Tonya M. Gilbert, Sofie Celen, Michel Koole, Isabeau Vermeulen, Kim Serdons, Frederick A. Schroeder, Florence Wagner, Tom Bleeser, Wim Vanduffel, Koen Van Laere, Janice E. Kranz, Jacob M. Hooker, Guy Bormans, Christopher Cawthorne
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)