Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
出版年份 2022 全文链接
标题
Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
作者
关键词
-
出版物
Antioxidants
Volume 11, Issue 1, Pages 124
出版商
MDPI AG
发表日期
2022-01-07
DOI
10.3390/antiox11010124
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Pilot trial of high-dose vitamin C in critically ill COVID-19 patients
- (2021) Jing Zhang et al. Annals of Intensive Care
- Neurodegenerative Disease and the NLRP3 Inflammasome
- (2021) Jonathan A. Holbrook et al. Frontiers in Pharmacology
- Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue
- (2021) Theoharis C. Theoharides et al. BIOFACTORS
- Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates
- (2021) Sajad Fakhri et al. MOLECULES
- Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
- (2021) Dorit Trudler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
- (2021) Hongxu Xian et al. IMMUNITY
- Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway
- (2021) Mingying Han et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex
- (2021) Jacques Hugon et al. JOURNAL OF NEUROLOGY
- Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson’s Disease
- (2021) Ifeoluwa O. Awogbindin et al. Frontiers in Cellular Neuroscience
- Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19
- (2021) Joe M. McCord et al. FREE RADICAL BIOLOGY AND MEDICINE
- IL-1 and IL-6 inhibition affects the neutralising activity of anti-SARS-CoV-2 antibodies in patients with COVID-19
- (2021) Emanuel Della-Torre et al. Lancet Rheumatology
- Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis
- (2020) Kun Wang et al. CELL
- Beyond repression of Nrf2: An update on Keap1
- (2020) Aleksandra Kopacz et al. FREE RADICAL BIOLOGY AND MEDICINE
- Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation
- (2020) Keliang Xie et al. INFLAMMATION RESEARCH
- The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
- (2020) Liam Baird et al. MOLECULAR AND CELLULAR BIOLOGY
- SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions
- (2020) Mohammed Uddin et al. Viruses-Basel
- COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy
- (2020) Carlo Perricone et al. IMMUNOLOGIC RESEARCH
- Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality
- (2020) Santosh Shenoy INFLAMMATION RESEARCH
- Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19
- (2020) Aditi Banerjee et al. LIFE SCIENCES
- Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
- (2020) Thomas F. Rogers et al. SCIENCE
- Targeting the NLRP3 Inflammasome in Severe COVID-19
- (2020) Tracey L. Freeman et al. Frontiers in Immunology
- Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
- (2020) Joe M. McCord et al. Antioxidants
- Coronavirus interactions with the cellular autophagy machinery
- (2020) Katelyn Miller et al. Autophagy
- Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?
- (2020) Antoni Sureda et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Inflammasome formation in the lungs of patients with fatal COVID-19
- (2020) Stefano Toldo et al. INFLAMMATION RESEARCH
- COVID-19 Infection: Viral Macro- and Micro-Vascular Coagulopathy and Thromboembolism/Prophylactic and Therapeutic Management
- (2020) Antonis S. Manolis et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
- (2020) Linlin Cheng et al. JOURNAL OF CLINICAL LABORATORY ANALYSIS
- COVID-19: discovery, diagnostics and drug development
- (2020) Tarik Asselah et al. JOURNAL OF HEPATOLOGY
- Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia
- (2020) Yang Liu et al. NEUROSCIENCE LETTERS
- Can Activation of NRF2 Be a Strategy against COVID-19?
- (2020) Antonio Cuadrado et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19
- (2020) M. Mrityunjaya et al. Frontiers in Immunology
- Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology
- (2020) Noemi Esteras et al. Cells
- Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
- (2020) An-Guo Wu et al. AGEING RESEARCH REVIEWS
- Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials
- (2020) Motoaki Sano et al. CURRENT PHARMACEUTICAL DESIGN
- T Cells: Warriors of SARS-CoV-2 Infection
- (2020) Paola de Candia et al. TRENDS IN IMMUNOLOGY
- Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond
- (2020) Mark F. McCarty et al. Nutrients
- Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- (2020) Jean Bousquet et al. Clinical and Translational Allergy
- 5-(3,4-Difluorophenyl)−3-(6-methylpyridin-3-yl)−1,2,4-oxadiazole (DDO-7263), a Novel Nrf2 Activator Targeting Brain Tissue, Protects Against MPTP-induced Subacute Parkinson's Disease in Mice by Inhibiting the NLRP3 Inflammasome and Protects PC12 Cells Against Oxidative Stress
- (2019) Li-Li Xu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Carnosic Acid Improves Outcome after Repetitive Mild Traumatic Brain Injury
- (2019) Mark E. Maynard et al. JOURNAL OF NEUROTRAUMA
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- (2019) Nathan Kelley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome
- (2019) Lingbin Sun et al. Cell Death & Disease
- NLRP3 inflammasome activation drives tau pathology
- (2019) Christina Ising et al. NATURE
- MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
- (2018) Eunju Lee et al. CELL DEATH AND DIFFERENTIATION
- A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age
- (2018) N.S.L. Perry et al. PHYTOMEDICINE
- Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
- (2018) Xing Li et al. Frontiers in Immunology
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- Combination of EPA with Carotenoids and Polyphenol Synergistically Attenuated the Transformation of Microglia to M1 Phenotype Via Inhibition of NF-κB
- (2017) Nurit Hadad et al. NEUROMOLECULAR MEDICINE
- Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms
- (2017) Margot Loussouarn et al. PLANT PHYSIOLOGY
- MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress
- (2017) Saumya Nagar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance
- (2016) Je-Wook Yu et al. ARCHIVES OF PHARMACAL RESEARCH
- The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer’s Disease
- (2016) Solomon Habtemariam Evidence-based Complementary and Alternative Medicine
- Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles
- (2016) Qian Sun et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice
- (2016) Qi Guo et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Oxidative Modification and Its Implications for the Neurodegeneration of Parkinson’s Disease
- (2016) Junjun Zhao et al. MOLECULAR NEUROBIOLOGY
- Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes
- (2016) Joseph Schwager et al. MOLECULES
- ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury
- (2016) Letteria Minutoli et al. Oxidative Medicine and Cellular Longevity
- Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models
- (2016) Stuart A Lipton et al. Cell Death & Disease
- Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- (2016) Jessy Moore et al. Nutrients
- Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential
- (2015) Takumi Satoh et al. ASN Neuro
- Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction
- (2015) Chi-Rei Wu et al. CHEMICO-BIOLOGICAL INTERACTIONS
- p62 links autophagy and Nrf2 signaling
- (2015) Tao Jiang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
- (2015) Lauren E. Tebay et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View
- (2015) Marcos Roberto de Oliveira MOLECULAR NEUROBIOLOGY
- Microglia-Mediated Inflammation and Neurodegenerative Disease
- (2015) Ling Xu et al. MOLECULAR NEUROBIOLOGY
- Mechanism of NLRP3 inflammasome activation
- (2014) Fayyaz S. Sutterwala et al. Annals of the New York Academy of Sciences
- The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
- (2013) Naeha Subramanian et al. CELL
- Rationally Designed Multi-Targeted Agents Against Neurodegenerative Diseases
- (2013) W. J. Geldenhuys et al. CURRENT MEDICINAL CHEMISTRY
- Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
- (2013) Takumi Satoh et al. FREE RADICAL BIOLOGY AND MEDICINE
- The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity
- (2013) S. Park et al. JOURNAL OF IMMUNOLOGY
- Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells
- (2013) Roberta Foresti et al. PHARMACOLOGICAL RESEARCH
- Real-time monitoring of inflammation status in 3T3-L1 adipocytes possessing a secretory Gaussia luciferase gene under the control of nuclear factor-kappa B response element
- (2012) Haruka Nagasaki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Effect of Rosemarinus officinalis L. on MMP-9, MCP-1 Levels, and Cell Migration in RAW 264.7 and Smooth Muscle Cells
- (2012) In Gyeong Chae et al. JOURNAL OF MEDICINAL FOOD
- Management of moderate to severe Alzheimer’s disease: Focus on memantine
- (2012) Evangelyn Dominguez et al. Taiwanese Journal of Obstetrics & Gynecology
- Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis
- (2012) Sahar Y Al-Okbi TOXICOLOGY AND INDUSTRIAL HEALTH
- Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia
- (2011) Mika Yanagitai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Anti-Inflammatory Effects of Supercritical Carbon Dioxide Extract and Its Isolated Carnosic Acid fromRosmarinus officinalisLeaves
- (2011) Chia-Feng Kuo et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes
- (2011) Takumi Satoh et al. JOURNAL OF NEUROCHEMISTRY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
- Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells
- (2009) Kunio Kosaka et al. JOURNAL OF BIOCHEMISTRY
- Activated Glutathione Metabolism Participates in Protective Effects of Carnosic Acid against Oxidative Stress in Neuronal HT22 Cells
- (2009) Yosei Tamaki et al. PLANTA MEDICA
- Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation
- (2008) Takumi Satoh et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3
- (2008) Girish Rachakonda et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners
- (2008) Takumi Satoh et al. NEUROSCIENCE LETTERS
- Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1
- (2007) Takumi Satoh et al. JOURNAL OF NEUROCHEMISTRY
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