Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

The Na+/Ca2+exchanger in Alzheimer’s disease

(2020) Anna Pannaccione et al.   CELL CALCIUM

The Influence of Baseline Alzheimer's Disease Severity on Cognitive Decline and CSF Biomarkers in the NILVAD Trial

(2020) Laila Abdullah et al.   Frontiers in Neurology

TRPC Channels in the SOCE Scenario

(2020) Jose J. Lopez et al.   Cells

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

(2020) Plamena R. Angelova et al.   CELL DEATH AND DIFFERENTIATION

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

(2020) Noemi Esteras et al.   FEBS Journal

Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia

(2020) Olga Kopach et al.   JOURNAL OF CELL SCIENCE

Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Aβ-evoked hippocampal pathology

(2020) Daniela Monteiro-Fernandes et al.   MOLECULAR PSYCHIATRY

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

(2020) Minrui Fan et al.   NATURE

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

(2020) Maria Calvo-Rodriguez et al.   Nature Communications

The structure of the MICU 1‐ MICU 2 complex unveils the regulation of the mitochondrial calcium uniporter

(2020) Wenping Wu et al.   EMBO JOURNAL

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

(2020) Plamena R. Angelova et al.   MEDICINAL RESEARCH REVIEWS

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration

(2020) Andrey Y. Abramov et al.   Life-Basel

Tau‐induced upregulation of C/EBPβ‐TRPC1‐SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration

(2020) Jinwang Ye et al.   AGING CELL

Functional properties and mode of regulation of the mitochondrial Na+/Ca2+ exchanger, NCLX

(2019) Marko Kostic et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Calcium signalling: a key regulator of neuronal migration

(2019) Shin-ichiro Horigane et al.   JOURNAL OF BIOCHEMISTRY

The Relationship Between the Use of Antihypertensive Drugs and the Incidence of Dementia in General Practices in Germany

(2019) Jens Bohlken et al.   JOURNAL OF ALZHEIMERS DISEASE

Four-repeat tauopathies

(2019) Thomas W. Rösler et al.   PROGRESS IN NEUROBIOLOGY

Amyloid-beta modulates low-threshold activated voltage-gated L-type calcium channels of arcuate neuropeptide Y neurons leading to calcium dysregulation and hypothalamic dysfunction

(2019) Makoto Ishii et al.   JOURNAL OF NEUROSCIENCE

Cellular mechanisms of complex I-associated pathology

(2019) Andrey Y. Abramov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Roles for the Endoplasmic Reticulum in Regulation of Neuronal Calcium Homeostasis

(2019) Nicholas E. Karagas et al.   Cells

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca 2+ handling

(2018) Domenico Cieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake

(2018) Maria Patron et al.   CELL DEATH AND DIFFERENTIATION

Is it All Said for NSAIDs in Alzheimer's Disease? Role of Mitochondrial Calcium Uptake

(2018) Sara Sanz-Blasco et al.   Current Alzheimer Research

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity

(2018) Plamena R. Angelova et al.   MOLECULAR NEUROBIOLOGY

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

Functional interplay between plasma membrane Ca 2+ -ATPase, amyloid β-peptide and tau

(2018) Ana M. Mata   NEUROSCIENCE LETTERS

Mitochondrial calcium imbalance in Parkinson’s disease

(2018) Marthe H.R. Ludtmann et al.   NEUROSCIENCE LETTERS

Calmodulin-binding proteins: A journey of 40 years

(2018) Rajendra K. Sharma et al.   CELL CALCIUM

Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria

(2018) James Hamilton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP)

(2018) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial

(2018) Brian Lawlor et al.   PLOS MEDICINE

Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

(2018) Thomas Briston et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Spatiotemporal pattern of calcium activity in astrocytic network

(2018) Alexey Semyanov   CELL CALCIUM

On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis

(2017) Estela Area-Gomez et al.   FASEB JOURNAL

Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity

(2017) Yan Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

(2017) Takashi Miyamoto et al.   Molecular Neurodegeneration

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

(2017) Noemí Esteras et al.   Redox Biology

A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration

(2017) Giuseppina Amadoro et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

(2017) Fernando Bartolome et al.   Scientific Reports

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Deficiency of Parkinson’s disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

(2016) Marta Delgado-Camprubi et al.   CELL DEATH AND DIFFERENTIATION

Calcium-Channel Blockers and Dementia Risk in Older Adults　– National Health Insurance Service – Senior Cohort (2002–2013) –

(2016) Deri Hwang et al.   CIRCULATION JOURNAL

Amlodipine treatment of hypertension associates with a decreased dementia risk

(2016) Leonid Feldman et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity

(2016) Jochen Martin Decker et al.   EMBO REPORTS

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

(2016) Dolores Del Prete et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Ca2+ uptake pathways

(2016) Pia A. Elustondo et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

(2016) Ian R. A. Mackenzie et al.   JOURNAL OF NEUROCHEMISTRY

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

(2016) Anil Noronha Antony et al.   Nature Communications

Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila

(2016) Ilaria Drago et al.   Cell Reports

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Calcium and mitochondria in the regulation of cell death

(2015) Sten Orrenius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ion Channel Formation by Tau Protein: Implications for Alzheimer’s Disease and Tauopathies

(2015) Nirav Patel et al.   BIOCHEMISTRY

Structure and function of the mitochondrial calcium uniporter complex

(2015) Diego De Stefani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

(2015) Kira M. Holmström et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Frontotemporal dementia

(2015) Jee Bang et al.   LANCET

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Ca2+ in neurodegenerative disorders

(2015) Rosella Abeti et al.   PHARMACOLOGICAL RESEARCH

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

(2015) Marko Kostic et al.   Cell Reports

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Unresolved questions from the analysis of mice lacking MCU expression

(2014) Elizabeth Murphy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection

(2014) M J Sisalli et al.   CELL DEATH AND DIFFERENTIATION

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

(2014) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease

(2013) Joe Atherton et al.   AGING CELL

Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity

(2013) Anna V. Kamynina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cytotoxicity of Intracellular A 42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

(2013) A. Demuro et al.   JOURNAL OF NEUROSCIENCE

Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

(2013) I. Llorente-Folch et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

Calmodulin levels in blood cells as a potential biomarker of Alzheimer’s disease

(2013) Noemí Esteras et al.   Alzheimers Research & Therapy

The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology

(2013) Diana Simón et al.   Frontiers in Neurology

Ca2+dysregulation in neurons from transgenic mice expressing mutant presenilin 2

(2012) Maulilio J. Kipanyula et al.   AGING CELL

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

Calmodulin antagonizes amyloid-β peptides-mediated inhibition of brain plasma membrane Ca2+-ATPase

(2012) Maria Berrocal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient reversal of the sodium/calcium exchanger boosts presynaptic calcium and synaptic transmission at a cerebellar synapse

(2012) Chris J. Roome et al.   JOURNAL OF NEUROPHYSIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes

(2012) I. Drago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

(2011) I.L. Ferreira et al.   CELL CALCIUM

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Unknown

(2011) Adriana Ferreira et al.   MOLECULAR MEDICINE

Implicating Calpain in Tau-Mediated Toxicity In Vivo

(2011) James B. Reinecke et al.   PLoS One

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

(2010) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

(2010) Pavel F. Pavlov et al.   FASEB JOURNAL

Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

(2010) Bin Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

Cytosolic Ca2+ Buffers

(2010) B. Schwaller   Cold Spring Harbor Perspectives in Biology

The Plasma Membrane Ca2+ ATPase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium

(2010) M. Brini et al.   Cold Spring Harbor Perspectives in Biology

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

(2008) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease

(2008) Lukasz Bojarski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calcium ions in neuronal degeneration

(2008) Urszula Wojda et al.   IUBMB LIFE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA