Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives

MAFLD: a holistic view to redefining fatty liver disease

(2021) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis

(2021) Mario Masarone et al.   Metabolomics

Modulation of the Gut Microbiota and Serum Biomarkers After Laparoscopic Sleeve Gastrectomy: a 1-Year Follow-Up Study

(2021) Mohsen Tabasi et al.   OBESITY SURGERY

Adaptations in gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass

(2021) Nele Steenackers et al.   Lancet Gastroenterology & Hepatology

The interplay of obesity, gut microbiome and diet in the immune check point inhibitors therapy era

(2021) Nikolaos Spyrou et al.   SEMINARS IN CANCER BIOLOGY

Do Antibiotics Cause Obesity Through Long-term Alterations in the Gut Microbiome? A Review of Current Evidence

(2021) Natalia Vallianou et al.   Current Obesity Reports

Gut Microbiome and Metabolites in Patients with NAFLD and after Bariatric Surgery: A Comprehensive Review

(2021) Jacqueline Hoozemans et al.   Metabolites

Role of intensive dietary and lifestyle interventions in the treatment of lean nonalcoholic fatty liver disease patients

(2020) Pinar Hamurcu Varol et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Influence of Exercise on the Human Gut Microbiota of Healthy Adults

(2020) Lourdes Ortiz-Alvarez et al.   Clinical and Translational Gastroenterology

Absence of the Caspases 1/11 Modulates Liver Global Lipid Profile and Gut Microbiota in High-Fat-Diet-Induced Obese Mice

(2020) Lívia Pimentel de Sant'Ana et al.   Frontiers in Immunology

Bile acids associate with specific gut microbiota, low‐level alcohol consumption and liver fibrosis in patients with non‐alcoholic fatty liver disease

(2020) Leon A. Adams et al.   LIVER INTERNATIONAL

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Impact of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy on gut microbiota: a metagenomic comparative analysis

(2020) William Farin et al.   Surgery for Obesity and Related Diseases

Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

(2020) Qing Ye et al.   Lancet Gastroenterology & Hepatology

Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives

(2020) Natalia Vallianou et al.   Current Obesity Reports

NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice

(2020) Joseph F. Cavallari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Trimethylamine N-Oxide levels are associated with NASH in obese subjects with type 2 diabetes

(2020) Paola León-Mimila et al.   DIABETES & METABOLISM

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

(2020) Xiang Zhang et al.   GUT

Roux-en-Y gastric bypass surgery changes fungal and bacterial microbiota in morbidly obese patients—A pilot study

(2020) Robert E. Steinert et al.   PLoS One

Effect of exercise on hepatic steatosis: Are benefits seen without dietary intervention? A systematic review and meta‐analysis

(2020) Callum John Baker et al.   Journal of Diabetes

High-Fat Proteins Drive Dynamic Changes in Gut Microbiota, Hepatic Metabolome, and Endotoxemia-TLR-4-NFκB-Mediated Inflammation in Mice

(2020) Muhammad Ijaz Ahmad et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass

(2020) Silvia Leite Faria et al.   OBESITY SURGERY

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

(2020) Giljae Lee et al.   Nature Communications

Can You Trust Your Gut? Implicating a Disrupted Intestinal Microbiome in the Progression of NAFLD/NASH

(2020) Kavita Jadhav et al.   Frontiers in Endocrinology

Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3

(2020) Marion Lenoir et al.   Gut Microbes

Changes in gut microbial flora after Roux-en-Y gastric bypass and sleeve gastrectomy and their effects on post-operative weight loss

(2020) Reza Karami et al.   Updates in Surgery

Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression

(2020) Nisreen Nimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis

(2019) Kai Schneider et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversal by anti-tnfa treatment

(2019) Tiziano Balzano et al.   JOURNAL OF HEPATOLOGY

Perspectives of Phage Therapy in Non-bacterial Infections

(2019) Andrzej Górski et al.   Frontiers in Microbiology

Non-alcoholic fatty liver disease causes dissociated changes in metabolic liver functions

(2019) Peter Lykke Eriksen et al.   Clinics and Research in Hepatology and Gastroenterology

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

(2019) Cyrielle Caussy et al.   Nature Communications

Non-alcoholic fatty liver disease is associated with dysregulated bile acid synthesis and diarrhea: A prospective observational study

(2019) Richard N. Appleby et al.   PLoS One

Beneficial effects of exercise on gut microbiota functionality and barrier integrity, and gut-liver crosstalk in an in vivo model of early obesity and non-alcoholic fatty liver disease

(2019) Sara Carbajo-Pescador et al.   Disease Models & Mechanisms

Exercise and the Gut Microbiome

(2019) Lucy J. Mailing et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Fecal Microbial Transplant Capsules are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial

(2019) Jasmohan S Bajaj et al.   HEPATOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Editing the microbiome the CRISPR way

(2019) Gayetri Ramachandran et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program

(2019) Yvonne Huber et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Circulating levels of butyrate are inversely related to portal hypertension, endotoxemia, and systemic inflammation in patients with cirrhosis

(2019) Oriol Juanola et al.   FASEB JOURNAL

Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice

(2019) Shixiang Zhai et al.   FEMS MICROBIOLOGY LETTERS

A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non‐Alcoholic Fatty Liver Disease

(2019) Petar Dianov Petrov et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

(2019) Natalia Vallianou et al.   Current Obesity Reports

Ammonia scavenging prevents progression of fibrosis in experimental non‐alcoholic fatty liver disease

(2019) Francesco De Chiara et al.   HEPATOLOGY

Non‐alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

(2019) Peter Lykke Eriksen et al.   LIVER INTERNATIONAL

Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits

(2019) Sara G. Higarza et al.   PLoS One

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

Ratio of Conjugated Chenodeoxycholic to Muricholic Acids is Associated with Severity of Nonalcoholic Steatohepatitis

(2019) Jin Chen et al.   Obesity

Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights

(2018) Kristen Stephenson et al.   GENE EXPRESSION

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

Urea cycle dysregulation in non-alcoholic fatty liver disease

(2018) Francesco De Chiara et al.   JOURNAL OF HEPATOLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Ammonia: A novel target for the treatment of non-alcoholic steatohepatitis

(2018) Karen Louise Thomsen et al.   MEDICAL HYPOTHESES

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans

(2018) JACOB M. ALLEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Role of Bile Acids in Metabolic Control

(2018) Antonio Molinaro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Bile Acids Activated Receptors Regulate Innate Immunity

(2018) Stefano Fiorucci et al.   Frontiers in Immunology

Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD

(2018) Eveline Gart et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis

(2018) Mengting Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome

(2018) Luigi Barrea et al.   Nutrients

Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women

(2018) Eveliina Munukka et al.   Frontiers in Microbiology

The AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics

(2017) Colleen R. Kelly et al.   GASTROENTEROLOGY

Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma

(2017) Alexander Gerbes et al.   GUT

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level

(2017) Wiley Barton et al.   GUT

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

(2017) Jasmohan S. Bajaj et al.   HEPATOLOGY

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics

(2017) Mireia Lopez-Siles et al.   ISME Journal

Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice

(2017) Eveliina Munukka et al.   ISME Journal

Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review

(2017) Ryuki Hashida et al.   JOURNAL OF HEPATOLOGY

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Weight and Metabolic Outcomes 12 Years after Gastric Bypass

(2017) Ted D. Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exercise Modifies the Gut Microbiota with Positive Health Effects

(2017) Vincenzo Monda et al.   Oxidative Medicine and Cellular Longevity

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

(2017) W.H. Wilson Tang et al.   Translational Research

Clinical epidemiology and disease burden of nonalcoholic fatty liver disease

(2017) Brandon J Perumpail et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

(2017) Cristina Llorente et al.   Nature Communications

Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B

(2017) Alexander Hodge et al.   Nutrients

Metabolic liver function in humans measured by 2-18F-fluoro-2-deoxy-D-galactose PET/CT–reproducibility and clinical potential

(2017) Kirstine P. Bak-Fredslund et al.   EJNMMI Research

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

(2017) Da Zhou et al.   Scientific Reports

Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD

(2017) Irene Pierantonelli et al.   Scientific Reports

Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis

(2016) O. J. Kennedy et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells

(2016) Liliana F. Iannucci et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

(2016) Dorien Reijnders et al.   Cell Metabolism

Pathophysiological mechanisms and therapeutic potentials of macrophages in non-alcoholic steatohepatitis

(2016) Ruonan Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach

(2016) Federica Del Chierico et al.   HEPATOLOGY

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Efficacy of probiotics in non-alcoholic fatty liver disease in adult and children: A meta-analysis of randomized controlled trials

(2016) Xiaolin Gao et al.   HEPATOLOGY RESEARCH

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Akkermansia muciniphilaimproves metabolic profiles by reducing inflammation in chow diet-fed mice

(2016) Shaoqian Zhao et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Comparison of Diet versus Exercise on Metabolic Function and Gut Microbiota in Obese Rats

(2016) REBECCA J. WELLY et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Durable coexistence of donor and recipient strains after fecal microbiota transplantation

(2016) Simone S. Li et al.   SCIENCE

Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease

(2016) Carrie R Wong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

(2016) Christopher Leung et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis

(2016) Wenxia Lu et al.   Gastroenterology Research and Practice

Impaired Gut-Liver-Brain Axis in Patients with Cirrhosis

(2016) Vishwadeep Ahluwalia et al.   Scientific Reports

Establishing a causal link between gut microbes, body weight gain and glucose metabolism in humans – towards treatment with probiotics

(2016) L.K. Stenman et al.   Beneficial Microbes

Akkermansia muciniphila: a novel functional microbe with probiotic properties

(2016) C. Gómez-Gallego et al.   Beneficial Microbes

Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

(2016) Albert Palleja et al.   Genome Medicine

Non-alcoholic fatty liver and the gut microbiota

(2016) Stavros Bashiardes et al.   Molecular Metabolism

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

(2016) Yu-ming Chen et al.   Scientific Reports

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet

(2016) Gabsik Yang et al.   Scientific Reports

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

(2015) Vishal Singh et al.   Cell Metabolism

Association Between Quantity of Liver Fat and Cardiovascular Risk in Patients With Nonalcoholic Fatty Liver Disease Independent of Nonalcoholic Steatohepatitis

(2015) Ahilan Arulanandan et al.   Clinical Gastroenterology and Hepatology

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

(2015) Brian C. Ferslew et al.   DIGESTIVE DISEASES AND SCIENCES

Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease

(2015) Venkatanarayana Gangarapu et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Association of Coffee Intake With Reduced Incidence of Liver Cancer and Death From Chronic Liver Disease in the US Multiethnic Cohort

(2015) Veronica Wendy Setiawan et al.   GASTROENTEROLOGY

Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

(2015) Jasmohan S. Bajaj et al.   HEPATOLOGY

Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

(2015) Dae-Bang Seo et al.   JOURNAL OF MEDICINAL FOOD

Decaffeinated green tea extract rich in epigallocatechin-3-gallate prevents fatty liver disease by increased activities of mitochondrial respiratory chain complexes in diet-induced obesity mice

(2015) Aline B. Santamarina et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease? – A mechanistic hypothesis

(2015) Ivanildo Coutinho de Medeiros et al.   MEDICAL HYPOTHESES

Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease

(2015) Ajay P. Belgaumkar et al.   OBESITY SURGERY

Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease

(2015) Weiwei Jiang et al.   Scientific Reports

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Experimental nonalcoholic steatohepatitis compromises ureagenesis, an essential hepatic metabolic function

(2014) Karen Louise Thomsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver

(2014) Hendrik Vilstrup et al.   HEPATOLOGY

Intestinal transport and metabolism of bile acids

(2014) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics

(2014) Theresa E. Cowan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

(2014) Salvatore Petta et al.   PLoS One

Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

(2014) Jin Zhou et al.   PLoS One

Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease

(2014) Giulia Paolella   WORLD JOURNAL OF GASTROENTEROLOGY

A Review of the Advancements in Probiotic Delivery: Conventional vs. Non-conventional Formulations for Intestinal Flora Supplementation

(2013) Mershen Govender et al.   AAPS PHARMSCITECH

Population-Attributable Fractions of Risk Factors for Hepatocellular Carcinoma in the United States

(2013) Tania M Welzel et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ammonia production by human faecal bacteria, and the enumeration, isolation and characterization of bacteria capable of growth on peptides and amino acids

(2013) Anthony J Richardson et al.   BMC MICROBIOLOGY

Cholineʼs role in maintaining liver function

(2013) Mihai G. Mehedint et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Influence of coffee (Coffea arabica) and galacto-oligosaccharide consumption on intestinal microbiota and the host responses

(2013) Tatsuya Nakayama et al.   FEMS MICROBIOLOGY LETTERS

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Association between thePNPLA3(rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data

(2013) Eric Trépo et al.   HEPATOLOGY

Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A double-blind placebo-controlled study

(2013) RYUICHIRO SAKATA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nonalcoholic Fatty Liver Disease

(2013) Ding-You Li et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Fat Diet Reduces the Formation of Butyrate, but Increases Succinate, Inflammation, Liver Fat and Cholesterol in Rats, while Dietary Fibre Counteracts These Effects

(2013) Greta Jakobsdottir et al.   PLoS One

Fructose as a key player in the development of fatty liver disease

(2013) Metin Basaranoglu   WORLD JOURNAL OF GASTROENTEROLOGY

Role of the advanced glycation end products receptor in Crohn’s disease inflammation

(2013) Rachele Ciccocioppo   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

(2013) Yan-Yan Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Personalizing Breast Cancer Staging by the Inclusion of ER, PR, and HER2

(2013) Sanjay P. Bagaria et al.   JAMA Surgery

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

(2012) Rohit Anthony Sinha et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease

(2012) Matteo Nicola Dario Di Minno   WORLD JOURNAL OF GASTROENTEROLOGY

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

The Bile Acid Membrane Receptor TGR5: A Valuable Metabolic Target

(2011) Thijs W.H. Pols et al.   DIGESTIVE DISEASES

Microglia activation in hepatic encephalopathy in rats and humans

(2011) Irina Zemtsova et al.   HEPATOLOGY

Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis

(2011) Jeffrey W. Molloy et al.   HEPATOLOGY

Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK

(2011) Jun Xu et al.   JOURNAL OF HEPATOLOGY

PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence

(2011) Edmondo Falleti et al.   LIVER INTERNATIONAL

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

(2011) Gianluca Svegliati-Baroni et al.   LIVER INTERNATIONAL

Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells

(2011) Armando Rojas et al.   MICROBES AND INFECTION

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Obesity, Diabetes, and Gut Microbiota: The hygiene hypothesis expanded?

(2010) G. Musso et al.   DIABETES CARE

Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

(2010) E F Murphy et al.   GUT

Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

(2010) Manal F. Abdelmalek et al.   HEPATOLOGY

Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins

(2010) Paola Vitaglione et al.   HEPATOLOGY

Elevated endotoxin levels in non-alcoholic fatty liver disease

(2010) Alison L Harte et al.   Journal of Inflammation-London

The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle

(2010) B. Høier et al.   JOURNAL OF PHYSIOLOGY-LONDON

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

(2009) N. N. Mehta et al.   DIABETES

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans

(2009) Kimber L. Stanhope et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Parental Obesity and Offspring Serum Alanine and Aspartate Aminotransferase Levels: The Framingham Heart Study

(2008) Rohit Loomba et al.   GASTROENTEROLOGY

Fructose consumption as a risk factor for non-alcoholic fatty liver disease

(2008) Xiaosen Ouyang et al.   JOURNAL OF HEPATOLOGY

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High-fat diet: A trigger of non-alcoholic steatohepatitis? Preliminary findings in obese subjects

(2008) Lisis Vilar et al.   NUTRITION

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA