Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Soluble dietary fiber improves energy homeostasis in obese mice by remodeling the gut microbiota

(2018) Haiyuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice

(2018) Youhua Xu et al.   JOURNAL OF ENDOCRINOLOGY

Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders

(2018) Marialetizia Rastelli et al.   Obesity

The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis

(2018) Jia Zheng et al.   PLoS One

Postbiotics: An evolving term within the functional foods field

(2018) J.E. Aguilar-Toalá et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Markers of metabolic endotoxemia as related to metabolic syndrome in an elderly male population at high cardiovascular risk: a cross-sectional study

(2018) Ayodeji Awoyemi et al.   Diabetology & Metabolic Syndrome

Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome

(2018) Kazuchika Nishitsuji et al.   Scientific Reports

Efficacy of synbiotic supplementation in obesity treatment: A systematic review and meta-analysis of clinical trials

(2018) Amir Hadi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Microbiome and diabetes: Where are we now?

(2018) Natalia G. Vallianou et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Gut microbiome and type 2 diabetes: where we are and where to go?

(2018) Sapna Sharma et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Obesity and cancer risk: Emerging biological mechanisms and perspectives

(2018) Konstantinos I. Avgerinos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery

(2017) Yan Guo et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction

(2017) Kristien E. Bouter et al.   GASTROENTEROLOGY

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

(2017) Zhuang Li et al.   GUT

Anti-obesity effect and protection of liver-kidney functions by Codium fragile sulphated polysaccharide on high fat diet induced obese rats

(2017) Rihab Ben Abdallah Kolsi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-κB signaling pathway

(2017) Mohammad Raish   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Polysaccharides from Chinese Liupao dark tea and their protective effect against hyperlipidemia

(2017) Yan Mao et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials

(2017) L Crovesy et al.   INTERNATIONAL JOURNAL OF OBESITY

Antiobesity Effect of Exopolysaccharides Isolated from Kefir Grains

(2017) Juha Lim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis

(2017) Dimitrios E. Magouliotis et al.   OBESITY SURGERY

Animal models for analyzing metabolic syndrome-associated liver diseases

(2017) Koichi Tsuneyama et al.   PATHOLOGY INTERNATIONAL

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

(2017) W.H. Wilson Tang et al.   Translational Research

Differences in gut microbiota profile between women with active lifestyle and sedentary women

(2017) Carlo Bressa et al.   PLoS One

An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children

(2017) Sofia Moran-Ramos et al.   Scientific Reports

Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population

(2017) Feitong Liu et al.   Scientific Reports

MDG-1, an Ophiopogon polysaccharide, alleviates hyperlipidemia in mice based on metabolic profile of bile acids

(2016) Linlin Shi et al.   CARBOHYDRATE POLYMERS

Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.)

(2016) Ji Won Choi et al.   CARBOHYDRATE POLYMERS

Correlation between body mass index and faecal microbiota from children

(2016) A. Ignacio et al.   CLINICAL MICROBIOLOGY AND INFECTION

Nonalcoholic Fatty Liver Disease and the Gut Microbiome

(2016) Jerome Boursier et al.   Clinics in Liver Disease

Effect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials

(2016) F Liu et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Efficacy of probiotics in non-alcoholic fatty liver disease in adult and children: A meta-analysis of randomized controlled trials

(2016) Xiaolin Gao et al.   HEPATOLOGY RESEARCH

Current Understanding of Dysbiosis in Disease in Human and Animal Models

(2016) Arianna K. DeGruttola et al.   INFLAMMATORY BOWEL DISEASES

Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity

(2016) Rebecca A. Haeusler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The gut microbiota and metabolic disease: current understanding and future perspectives

(2016) T. Arora et al.   JOURNAL OF INTERNAL MEDICINE

Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat

(2016) Felicia Goldsmith et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

A microbial perspective of human developmental biology

(2016) Mark R. Charbonneau et al.   NATURE

The microbiome in early life: implications for health outcomes

(2016) Sabrina Tamburini et al.   NATURE MEDICINE

Exposing the exposures responsible for type 2 diabetes and obesity

(2016) P. W. Franks et al.   SCIENCE

Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome

(2016) Marc A. Sze et al.   mBio

Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

(2016) Albert Palleja et al.   Genome Medicine

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Intestinal Microbiota Is Influenced by Gender and Body Mass Index

(2016) Carmen Haro et al.   PLoS One

Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing

(2015) Chika Kasai et al.   BMC GASTROENTEROLOGY

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Gut–liver axis, nutrition, and non-alcoholic fatty liver disease

(2015) Irina A. Kirpich et al.   CLINICAL BIOCHEMISTRY

The influence of diet on the gut microbiota and its consequences for health

(2015) Joël Doré et al.   CURRENT OPINION IN BIOTECHNOLOGY

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Study of the diversity and short-chain fatty acids production by the bacterial community in overweight and obese Mexican children

(2015) S. Murugesan et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Characterization and Antihyperglycemic Activity of a Polysaccharide from Dioscorea opposita Thunb Roots

(2015) Yijun Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial

(2015) Cécile Vors et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Consumption of Synbiotic Bread ContainingLactobacillus sporogenesand Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial

(2015) Fereashteh Bahmani et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Beta-diversity metrics of the upper digestive tract microbiome are associated with body mass index

(2015) Shih-Wen Lin et al.   Obesity

Identifying strains that contribute to complex diseases through the study of microbial inheritance

(2015) Jeremiah J. Faith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Surgical and Dietary Weight Loss Therapy for Obesity on Gut Microbiota Composition and Nutrient Absorption

(2015) Antje Damms-Machado et al.   Biomed Research International

Anti-obesity and lipid lowering effects ofCymodocea nodosasulphated polysaccharide on high cholesterol-fed-rats

(2015) Rihab Ben Abdallah Kolsi et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients

(2015) Philip Prinz et al.   Frontiers in Neuroscience

Obesity Alters the Microbial Community Profile in Korean Adolescents

(2015) Hae-Jin Hu et al.   PLoS One

MDG-1, a polysaccharide from Ophiopogon japonicus, prevents high fat diet-induced obesity and increases energy expenditure in mice

(2014) Yuan Wang et al.   CARBOHYDRATE POLYMERS

Interactions between cellulose ethers and a bile salt in the control of lipid digestion of lipid-based systems

(2014) Amelia Torcello-Gómez et al.   CARBOHYDRATE POLYMERS

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

(2014) Annick V. Hartstra et al.   DIABETES CARE

Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge

(2014) Isabel Bondia-Pons et al.   FASEB JOURNAL

Meta-analyses of human gut microbes associated with obesity and IBD

(2014) William A. Walters et al.   FEBS LETTERS

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice

(2014) Fernando F Anhê et al.   GUT

Microbiota and diabetes: an evolving relationship

(2014) Herbert Tilg et al.   GUT

Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula

(2014) Jia Xu et al.   ISME Journal

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

A Taxonomic Signature of Obesity in the Microbiome? Getting to the Guts of the Matter

(2014) Mariel M. Finucane et al.   PLoS One

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

Plasma Lipopolysaccharide Is Closely Associated With Glycemic Control and Abdominal Obesity: Evidence from bariatric surgery

(2013) M. Troseid et al.   DIABETES CARE

Hypolipidemic and antioxidant properties of a polysaccharide fraction from Enteromorpha prolifera

(2013) Zhihong Tang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Benefits of polyphenols on gut microbiota and implications in human health

(2013) Fernando Cardona et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gut Microbiota Composition Modifies Fecal Metabolic Profiles in Mice

(2013) Ying Zhao et al.   JOURNAL OF PROTEOME RESEARCH

Components of the Interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffness

(2013) Thomas W. Weiss et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance

(2013) Xiuying Zhang et al.   PLoS One

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota

(2012) Audrey M. Neyrinck et al.   BRITISH JOURNAL OF NUTRITION

Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice

(2012) B. M. Carvalho et al.   DIABETOLOGIA

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

(2012) J Graessler et al.   PHARMACOGENOMICS JOURNAL

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

Intestinal microbiota is a plastic factor responding to environmental changes

(2012) Marco Candela et al.   TRENDS IN MICROBIOLOGY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii

(2011) M Million et al.   INTERNATIONAL JOURNAL OF OBESITY

Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics

(2011) T A Ajslev et al.   INTERNATIONAL JOURNAL OF OBESITY

Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

(2011) J M Moreno-Navarrete et al.   INTERNATIONAL JOURNAL OF OBESITY

Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control

(2011) Thi-Mai Anh Dao et al.   PLoS One

Obesity, Diabetes, and Gut Microbiota: The hygiene hypothesis expanded?

(2010) G. Musso et al.   DIABETES CARE

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

(2010) Sylvie Rabot et al.   FASEB JOURNAL

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Vancomycin Treatment of Infective Endocarditis Is Linked with Recently Acquired Obesity

(2010) Franck Thuny et al.   PLoS One

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

(2009) N. N. Mehta et al.   DIABETES

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

The bifidogenic effect of inulin and oligofructose and its consequences for gut health

(2009) D Meyer et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Chylomicrons promote intestinal absorption of lipopolysaccharides

(2008) Sarbani Ghoshal et al.   JOURNAL OF LIPID RESEARCH

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Is meconium from healthy newborns actually sterile?

(2008) Esther Jiménez et al.   RESEARCH IN MICROBIOLOGY