New Developments in T Cell Immunometabolism and Implications for Cancer Immunotherapy
出版年份 2022 全文链接
标题
New Developments in T Cell Immunometabolism and Implications for Cancer Immunotherapy
作者
关键词
-
出版物
Cells
Volume 11, Issue 4, Pages 708
出版商
MDPI AG
发表日期
2022-02-18
DOI
10.3390/cells11040708
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Adoptive Transfer of Regulatory Immune Cells in Organ Transplantation
- (2021) Nathaniel Oberholtzer et al. Frontiers in Immunology
- Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
- (2021) Kai Tang et al. Journal of Hematology & Oncology
- Cell-programmed nutrient partitioning in the tumour microenvironment
- (2021) Bradley I. Reinfeld et al. NATURE
- Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity
- (2021) Jingya Guo et al. CELL RESEARCH
- A phase I study of an IDO inhibitor (SHR9146) plus camrelizumab and in combination with/without apatinib in patients with advanced solid tumors: Safety and efficacy analysis.
- (2021) Ying Cheng et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I study of BJ-001, a tumor-targeting interleukin-15 fusion protein, in patients with solid tumor.
- (2021) Ki Y. Chung et al. JOURNAL OF CLINICAL ONCOLOGY
- Safety and efficacy of the anti-CD73 monoclonal antibody (mAb) oleclumab ± durvalumab in patients (pts) with advanced colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), or EGFR-mutant non-small cell lung cancer (EGFRm NSCLC).
- (2021) Johanna C. Bendell et al. JOURNAL OF CLINICAL ONCOLOGY
- IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin
- (2021) Nengzhi Pang et al. Journal of Hematology & Oncology
- Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity
- (2021) Yugang Guo et al. NATURE IMMUNOLOGY
- Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
- (2020) Dominic G. Roy et al. Cell Metabolism
- Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
- (2020) Nina Dumauthioz et al. Cellular & Molecular Immunology
- CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
- (2020) Haiping Wang et al. NATURE IMMUNOLOGY
- Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells
- (2020) Boyoung Shin et al. Cell Reports
- A phase I, open-label, multicenter study to assess the safety, pharmacokinetics, and preliminary antitumor activity of AZD4635 both as monotherapy and in combination in patients with advanced solid malignancies: Results from prostate cancer patients (NCT02740985).
- (2020) Emerson A. Lim et al. JOURNAL OF CLINICAL ONCOLOGY
- Metabolic signaling in T cells
- (2020) Justin A. Shyer et al. CELL RESEARCH
- Organoid Models of Tumor Immunology
- (2020) Kanako Yuki et al. TRENDS IN IMMUNOLOGY
- CD38: T Cell Immuno-Metabolic Modulator
- (2020) Anwesha Kar et al. Cells
- The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome
- (2020) Iosifina P. Foskolou et al. Blood Advances
- Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer
- (2020) Veronica Mariotti et al. JAMA Oncology
- Immunometabolism in the Tumor Microenvironment
- (2020) Dominic G. Roy et al. Annual Review of Cancer Biology-Series
- IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion
- (2019) Kevin C Conlon et al. CLINICAL CANCER RESEARCH
- The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications
- (2019) Warren J. Leonard et al. IMMUNITY
- Thioredoxin-1 improves the immuno-metabolic phenotype of anti-tumor T cells
- (2019) Paramita Chakraborty et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Immunobiology, preliminary safety, and efficacy of CPI-006, an anti-CD73 antibody with immune modulating activity, in a phase 1 trial in advanced cancers.
- (2019) Jason J. Luke et al. JOURNAL OF CLINICAL ONCOLOGY
- HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
- (2019) Jason Miska et al. Cell Reports
- Acetate Promotes T Cell Effector Function during Glucose Restriction
- (2019) Jing Qiu et al. Cell Reports
- Antigen receptor control of methionine metabolism in T cells
- (2019) Linda V Sinclair et al. eLife
- Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
- (2019) Zhilin Hu et al. Cell Metabolism
- TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma
- (2019) Xiaochen Wang et al. JOURNAL OF HEPATOLOGY
- TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
- (2019) Francesca Alfei et al. NATURE
- TOX is a critical regulator of tumour-specific T cell differentiation
- (2019) Andrew C. Scott et al. NATURE
- TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
- (2019) Omar Khan et al. NATURE
- PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance
- (2019) Vivek Verma et al. NATURE IMMUNOLOGY
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
- (2019) Hyungseok Seo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases
- (2019) Kelly A. Hogan et al. Frontiers in Immunology
- AGK Unleashes CD8+ T Cell Glycolysis to Combat Tumor Growth
- (2019) Peipei Zhou et al. Cell Metabolism
- Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance
- (2019) Dayana B. Rivadeneira et al. IMMUNITY
- Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells
- (2019) Ping-Hsien Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity
- (2019) Paramita Chakraborty et al. Cell Reports
- Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges
- (2019) Muhammad Zaeem Noman et al. Cells
- 113P A phase I study of an anti-IDO1 inhibitor (LY3381916) as monotherapy and in combination with an anti-PD-L1 antibody (LY3300054) in patients with advanced cancer
- (2019) N Kotecki et al. ANNALS OF ONCOLOGY
- 101P Results of the NLG2105 phase I trial using the IDO pathway inhibitor indoximod, in combination with radiation and chemotherapy, for children with newly diagnosed DIPG
- (2019) T S Johnson et al. ANNALS OF ONCOLOGY
- Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
- (2019) Stefano Angiari et al. Cell Metabolism
- Metabolic Consequences of T-cell Costimulation in Anticancer Immunity
- (2019) Alvaro Teijeira et al. Cancer Immunology Research
- Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
- (2019) Beatris Mastelic-Gavillet et al. Journal for ImmunoTherapy of Cancer
- Model of Patient-Specific Immune-Enhanced Organoids for Immunotherapy Screening: Feasibility Study
- (2019) Konstantinos I. Votanopoulos et al. ANNALS OF SURGICAL ONCOLOGY
- Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
- (2019) Cameron S. Field et al. Cell Metabolism
- Tumor organoid–T-cell coculture systems
- (2019) Chiara M. Cattaneo et al. Nature Protocols
- Metabolic Pathways Involved in Regulatory T Cell Functionality
- (2019) Rosalie W. M. Kempkes et al. Frontiers in Immunology
- Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity
- (2019) Hao Shi et al. Frontiers in Immunology
- Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation
- (2018) Danielle A. Chisolm et al. Annual Review of Immunology
- Th9 Cells Represent a Unique Subset of CD4 + T Cells Endowed with the Ability to Eradicate Advanced Tumors
- (2018) Yong Lu et al. CANCER CELL
- Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models
- (2018) Robert D. Leone et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
- (2018) Tina Cascone et al. Cell Metabolism
- CD38-NAD + Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
- (2018) Shilpak Chatterjee et al. Cell Metabolism
- Phase Ib trial of ALT-803, an IL-15 superagonist, plus BCG for the treatment of BCG-naïve patients with non-muscle-invasive bladder cancer.
- (2018) Charles Joel Rosser et al. JOURNAL OF CLINICAL ONCOLOGY
- 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
- (2018) Ashley V. Menk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Metabolic Barriers to T Cell Function in Tumors
- (2018) Ayaka Sugiura et al. JOURNAL OF IMMUNOLOGY
- Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
- (2018) Ilenia Pacella et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
- (2018) Deng Pan et al. SCIENCE
- CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade
- (2018) Limo Chen et al. Cancer Discovery
- IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner
- (2018) Romy Loschinski et al. Oncotarget
- Epigenetic Maintenance of Acquired Gene Expression Programs during Memory CD8 T Cell Homeostasis
- (2018) Hossam A. Abdelsamed et al. Frontiers in Immunology
- Targeting adenosine for cancer immunotherapy
- (2018) Robert D. Leone et al. Journal for ImmunoTherapy of Cancer
- Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
- (2018) Asha Nayak-Kapoor et al. Journal for ImmunoTherapy of Cancer
- Abstract CT180: Preliminary phase 1 profile of BMS-986179, an anti-CD73 antibody, in combination with nivolumab in patients with advanced solid tumors
- (2018) Lillian L. Siu et al. CANCER RESEARCH
- Durable clinical responses observed from non-Hodgkin lymphoma patients treated with autologous CAR-T cells targeting CD19.
- (2018) Yarong Liu et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase 2 trial of the IDO pathway inhibitor indoximod plus gemcitabine / nab-paclitaxel for the treatment of patients with metastatic pancreas cancer.
- (2018) Nathan Bahary et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I/II study of the A2AR antagonist NIR178 (PBF-509), an oral immunotherapy, in patients (pts) with advanced NSCLC.
- (2018) Alberto Chiappori et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase 2 trial of the IDO pathway inhibitor indoximod plus checkpoint inhibition for the treatment of patients with advanced melanoma.
- (2018) Yousef Zakharia et al. JOURNAL OF CLINICAL ONCOLOGY
- PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy
- (2018) Partha S. Chowdhury et al. Cancer Immunology Research
- GITR Agonism Enhances Cellular Metabolism to Support CD8+ T-cell Proliferation and Effector Cytokine Production in a Mouse Tumor Model
- (2018) Simran S. Sabharwal et al. Cancer Immunology Research
- Targeting PIM Kinase with PD1 inhibition Improves Immunotherapeutic Antitumor T-cell Response
- (2018) Shilpak Chatterjee et al. CLINICAL CANCER RESEARCH
- Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity
- (2018) Peer W. F. Karmaus et al. NATURE
- A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)–only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer
- (2017) Rebecca Kristeleit et al. GYNECOLOGIC ONCOLOGY
- Glutathione Primes T Cell Metabolism for Inflammation
- (2017) Tak W. Mak et al. IMMUNITY
- Metabolic reprogramming of human CD8+memory T cells through loss of SIRT1
- (2017) Mark Y. Jeng et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma
- (2017) Si-Rui Ma et al. Molecular Cancer
- Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
- (2017) Tao Xu et al. NATURE
- Effector CD8 T cells dedifferentiate into long-lived memory cells
- (2017) Ben Youngblood et al. NATURE
- Chromatin states define tumour-specific T cell dysfunction and reprogramming
- (2017) Mary Philip et al. NATURE
- A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells
- (2017) Ruihua Ma et al. NATURE CELL BIOLOGY
- Cytokine Signaling in the Development and Homeostasis of Regulatory T cells
- (2017) Kevin H. Toomer et al. Cold Spring Harbor Perspectives in Biology
- The Common Cytokine Receptor γ Chain Family of Cytokines
- (2017) Jian-Xin Lin et al. Cold Spring Harbor Perspectives in Biology
- Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
- (2017) Shan He et al. Nature Communications
- Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells
- (2017) Thomas Shum et al. Cancer Discovery
- Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l
- (2017) Jinbeom Heo et al. Cell Reports
- Nutrient and Metabolic Sensing in T Cell Responses
- (2017) Jun Wei et al. Frontiers in Immunology
- Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy
- (2016) Gideon Gross et al. Annual Review of Pharmacology and Toxicology
- Lack of p53 Augments Antitumor Functions in Cytolytic T Cells
- (2016) Anirban Banerjee et al. CANCER RESEARCH
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
- (2016) Michael D. Buck et al. CELL
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy
- (2016) Madhusudhanan Sukumar et al. Cell Metabolism
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies
- (2016) A. M. Monjazeb et al. CLINICAL CANCER RESEARCH
- Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status
- (2016) Yosra Messai et al. EUROPEAN UROLOGY
- Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
- (2016) Omkar U. Kawalekar et al. IMMUNITY
- Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
- (2016) Andrea Schietinger et al. IMMUNITY
- Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4 + T Cells
- (2016) Yu Wang et al. IMMUNITY
- The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
- (2016) Nicole E. Scharping et al. IMMUNITY
- Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
- (2016) Bertram Bengsch et al. IMMUNITY
- HDAC5 controls the functions of Foxp3+ T-regulatory and CD8+ T cells
- (2016) Haiyan Xiao et al. INTERNATIONAL JOURNAL OF CANCER
- T-Cell Therapy Using Interleukin-21–Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression
- (2016) Aude G. Chapuis et al. JOURNAL OF CLINICAL ONCOLOGY
- Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient
- (2016) Aude G. Chapuis et al. JOURNAL OF EXPERIMENTAL MEDICINE
- S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
- (2016) Petros A. Tyrakis et al. NATURE
- Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
- (2016) M. Peng et al. SCIENCE
- The epigenetic landscape of T cell exhaustion
- (2016) D. R. Sen et al. SCIENCE
- Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
- (2016) K. E. Pauken et al. SCIENCE
- IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
- (2016) David H. Munn et al. TRENDS IN IMMUNOLOGY
- Cell-Intrinsic Barriers of T Cell-Based Immunotherapy
- (2016) Hazem E. Ghoneim et al. TRENDS IN MOLECULAR MEDICINE
- Histone deacetylase inhibitors as immunomodulators in cancer therapeutics
- (2016) Li Shen et al. Epigenomics
- Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host
- (2016) Anna Schurich et al. Cell Reports
- Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia
- (2016) Nicole E. Scharping et al. Cancer Immunology Research
- Hypoxia and metabolic adaptation of cancer cells
- (2016) K L Eales et al. Oncogenesis
- Hypoxia and antitumor CD8+ T cells: An incompatible alliance?
- (2016) Romain Vuillefroy de Silly et al. OncoImmunology
- Harnessing the IL-7/IL-7Rαaxis to improve tumor immunotherapy
- (2016) C. Bryce Johnson et al. OncoImmunology
- Targeting CD73 in the tumor microenvironment with MEDI9447
- (2016) Carl M. Hay et al. OncoImmunology
- Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism
- (2016) Aldo Vacaflores et al. PLoS One
- Increased expression of IDO associates with poor postoperative clinical outcome of patients with gastric adenocarcinoma
- (2016) Hao Liu et al. Scientific Reports
- IL-12 conditioning improves retrovirally mediated transduction efficiency of CD8+ T cells
- (2015) K Andrijauskaite et al. CANCER GENE THERAPY
- Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8+ T cells
- (2015) Mark P. Rubinstein et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity
- (2015) Guoliang Cui et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
- (2015) Padmanee Sharma et al. CELL
- Acetyl Coenzyme A: A Central Metabolite and Second Messenger
- (2015) Federico Pietrocola et al. Cell Metabolism
- Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival
- (2015) Ulf H. Beier et al. FASEB JOURNAL
- Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
- (2015) Kevin C. Conlon et al. JOURNAL OF CLINICAL ONCOLOGY
- 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- (2015) Adrienne H Long et al. NATURE MEDICINE
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Immunological mechanisms of the antitumor effects of supplemental oxygenation
- (2015) Stephen M. Hatfield et al. Science Translational Medicine
- Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
- (2015) Robert Haas et al. PLOS BIOLOGY
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions
- (2015) Clovis S. Palmer et al. Frontiers in Immunology
- Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD
- (2015) Cen Zhang et al. Oncotarget
- Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
- (2014) S. Chatterjee et al. CANCER RESEARCH
- Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions
- (2014) P. Kesarwani et al. CANCER RESEARCH
- Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
- (2014) D. Mittal et al. CANCER RESEARCH
- The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
- (2014) Andrew N. Macintyre et al. Cell Metabolism
- Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
- (2014) Mako Nakaya et al. IMMUNITY
- Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation
- (2014) Brendan E. Russ et al. IMMUNITY
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
- (2014) Muhammad Zaeem Noman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
- (2014) Bryce W. Carey et al. NATURE
- SIRT1 and other sirtuins in metabolism
- (2014) Hung-Chun Chang et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study
- (2014) Shailender Bhatia et al. Journal for ImmunoTherapy of Cancer
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
- (2013) I. B. Barsoum et al. CANCER RESEARCH
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
- (2013) B. Allard et al. CLINICAL CANCER RESEARCH
- Long-lasting Disease Stabilization in the Absence of Toxicity in Metastatic Lung Cancer Patients Vaccinated with an Epitope Derived from Indoleamine 2,3 Dioxygenase
- (2013) T. Z. Iversen et al. CLINICAL CANCER RESEARCH
- Th9 cells: differentiation and disease
- (2013) Mark H. Kaplan IMMUNOLOGICAL REVIEWS
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity
- (2013) Yujie Liu et al. NATURE MEDICINE
- GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry
- (2012) C.-J. Ku et al. BLOOD
- IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
- (2012) N. Cieri et al. BLOOD
- A Phase I Dose-Finding Trial of Recombinant Interleukin-21 and Rituximab in Relapsed and Refractory Low Grade B-cell Lymphoproliferative Disorders
- (2012) J. M. Timmerman et al. CLINICAL CANCER RESEARCH
- Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
- (2012) C. Escande et al. DIABETES
- PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells
- (2012) David K. Finlay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development
- (2012) Changwan Hong et al. SEMINARS IN IMMUNOLOGY
- Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape
- (2012) Salem Chouaib et al. Frontiers in Immunology
- Th17 cells have stem cell-like features and promote long-term immunity
- (2012) Shuang Wei et al. OncoImmunology
- IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance
- (2011) John B. Mumm et al. CANCER CELL
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature
- (2011) Pawel Muranski et al. IMMUNITY
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer
- (2011) Chantal Mengus et al. Journal of Translational Medicine
- SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
- (2011) L. Peng et al. MOLECULAR AND CELLULAR BIOLOGY
- Cancer immunotherapy comes of age
- (2011) Ira Mellman et al. NATURE
- An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
- (2011) Christiane A. Opitz et al. NATURE
- Human TH17 Cells Are Long-Lived Effector Memory Cells
- (2011) I. Kryczek et al. Science Translational Medicine
- CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
- (2010) Xiaofeng Sun et al. GASTROENTEROLOGY
- Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
- (2010) Thomas R. Malek et al. IMMUNITY
- An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
- (2010) J. D. Mezrich et al. JOURNAL OF IMMUNOLOGY
- IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo
- (2010) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling
- (2010) Aimee J. Marko et al. PLoS One
- Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
- (2010) J. Stagg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes
- (2009) M. D. Sharma et al. BLOOD
- CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions
- (2009) Eduardo Chini CURRENT PHARMACEUTICAL DESIGN
- Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells
- (2009) Gang Wei et al. IMMUNITY
- Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells
- (2009) Yasuto Araki et al. IMMUNITY
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- mTOR regulates memory CD8 T-cell differentiation
- (2009) Koichi Araki et al. NATURE
- IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
- (2008) C. S. Hinrichs et al. BLOOD
- Tumor-specific Th17-polarized cells eradicate large established melanoma
- (2008) P. Muranski et al. BLOOD
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