Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wei Guo, Yadi Xing, Xiumei Luo, Fuguang Li, Maozhi Ren, Yiming Liang
Summary: Reactive oxygen species (ROS) are crucial regulators in both plant and human cells, serving as messengers in multiple pathways. While they play a beneficial role in growth and development, excessive ROS can cause oxidative stress and damage cellular functions. This review highlights the current research and mechanisms of ROS in both kingdoms, emphasizing their interactions with other substances and proposing potential opportunities for novel therapeutic strategies and agricultural advancements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Marc Herb, Alexander Gluschko, Michael Schramm
Summary: Reactive oxygen species (ROS) play important roles in cellular processes but can also lead to diseases, their effects depending on cell type and ROS production conditions. Cellular redox balance, like cell pH and calcium levels, is tightly controlled, with evidence showing that cells regulate ROS production by controlling activation and localization factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hee Jin Jung, Dong Chan Choi, Sang Gyun Noh, Heejeong Choi, Inkyu Choi, Il Young Ryu, Hae Young Chung, Hyung Ryong Moon
Summary: Thirteen (Z)-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among these compounds, compounds 1-3 displayed stronger tyrosinase inhibitory activity and could inhibit melanin production through different pathways.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Engineering, Environmental
Guoqiang Zhao, Binbin Wu, Xiaoshan Zheng, Baoliang Chen, Andreas Kappler, Chiheng Chu
Summary: We have discovered an unrecognized tidal source of reactive oxygen species (ROS) and demonstrated the generation of ROS in coastal surface soil during tidal processes. The fluctuation of redox potential and dissolved oxygen concentration follows a similar pattern to the production of ROS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Materials Science, Multidisciplinary
Dnyaneshwar Kalyane, Devendra Choudhary, Suryanarayana Polaka, Hanmant Goykar, Tukaram Karanwad, Kuldeep Rajpoot, Rakesh Kumar Tekade
Summary: Reactive oxygen species (ROS) play a dual role in tumor cell growth, depending on their concentration. Fine-tuning ROS levels in tumor cells can promote ROS-induced apoptotic signaling. This review also discusses the mechanisms of ROS generation by nanogenerators and methods to achieve higher anticancer activity in tumor tissue.
PROGRESS IN MATERIALS SCIENCE
(2022)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Oncology
Ramona Palombo, Ilaria Passacantilli, Francesca Terracciano, Alessia Capone, Alessandro Matteocci, Simon Tournier, Antonio Alberdi, Valerio Chiurchiu, Elisabetta Volpe, Maria Paola Paronetto
Summary: In this study, the researchers identified ATF3 as a key mediator of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells. ATF3 promotes tumor growth and metastasis by modulating the expression of chemokine-encoding genes, including CXCL8. This study provides valuable insights into the chemokine signaling in Ewing sarcoma and suggests that targeting the PI3K/AKT/mTOR pathway could promote an anti-tumoral immune response.
Article
Biochemistry & Molecular Biology
Teresa Giannattasio, Erika Testa, Ramona Palombo, Lidia Chellini, Flavia Franceschini, Alvaro Crevenna, Petko M. Petkov, Maria Paola Paronetto, Marco Barchi
Summary: In mammals, meiotic recombination is initiated by the introduction of DNA double strand breaks (DSBs) into narrow segments of the genome, defined as hotspots, which is carried out by the SPO11/TOPOVIBL complex. PRDM9 plays a major role in specifying hotspots by generating trimethylation on specific lysine residues of histone H3. Recently, FUS/TLS has been found to interact with PRDM9 and REC114, suggesting that it is a component of the protein complex involved in meiotic recombination initiation. Furthermore, FUS/TLS is localized at H3K4me3-marked hotspots and the pseudo-autosomal region.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Laura Sireno, Veronica Lisi, Cristina Fantini, Elisa Moretti, Ivan Dimauro, Paolo Sgro, Luigi Di Luigi, Attilio Parisi, Daniela Caporossi
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Ivan Dimauro, Daniela Caporossi
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Andrea Fusco, Laura Capranica, Federico Palumbo, Giulio Mosci, Simone Ciaccioni, Mojca Doupona, Cristina Cortis, Flavia Guidotti
Summary: The purpose of this study was to investigate the motivation of Italian elite coaches to engage in sport-related academic education, as well as the demands, barriers, support, and relocation issues they face in their dual career path. The findings emphasize the complexity of coach lifelong education at the university level and provide valuable information for promoting recommendations for elite athletes' dual careers in Europe and Italy.
Review
Green & Sustainable Science & Technology
Flavia Guidotti, Sabrina Demarie, Simone Ciaccioni, Laura Capranica
Summary: This umbrella review aimed to analyze the knowledge/competencies/skills in sport management, propose a competency framework, and provide insights for curricula implementation. From 22 retained review manuscripts, 72 items of knowledge/competencies/skills were extracted. Based on the evidence, a comprehensive framework for sport management was developed. The findings can foster the debate for the sustainable growth of this research area.
Review
Green & Sustainable Science & Technology
Flavia Guidotti, Sabrina Demarie, Simone Ciaccioni, Laura Capranica
Summary: This systematic review aims to provide a comprehensive overview of sport management relevant knowledge, competencies, and skills by analyzing and harmonizing the European skills classification for sport management employment profiles and evidence-based information from the scientific literature. The findings showed scholars' interest in deepening the understanding of necessary sport management-related knowledge/competencies/skills from different research perspectives. However, there is a disconnect between industry demands and students and/or employees' preparedness and performance, highlighting the need to update education and training to foster the sustainable development of this scientific area.
Article
Biochemistry & Molecular Biology
Chantalle Moulton, Elisa Grazioli, Cristina Antinozzi, Cristina Fantini, Claudia Cerulli, Arianna Murri, Guglielmo Duranti, Roberta Ceci, Maria Chiara Vulpiani, Patrizia Pellegrini, Sveva Maria Nusca, Francesco Cavaliere, Simona Fabbri, Paolo Sgro, Luigi Di Luigi, Daniela Caporossi, Attilio Parisi, Ivan Dimauro
Summary: Exercise has positive effects on post-surgery breast cancer patients undergoing adjuvant therapy, maintaining redox homeostasis, improving physical fitness and mental well-being.
Review
Sport Sciences
Federico Palumbo, Simone Ciaccioni, Flavia Guidotti, Roberta Forte, Attilio Sacripanti, Laura Capranica, Antonio Tessitore
Summary: This systematic overview aimed to review studies investigating the benefits and risks of judo training in older people, and to explore practical methodological applications. A total of 23 records meeting the inclusion criteria were identified through searches of EBSCOhost, ISI-WoS, and Scopus databases. The quality assessment revealed a serious risk of bias in 70% of the experimental studies, while all observational studies and 67% of the methodological studies presented a fair quality.
Article
Biochemistry & Molecular Biology
Veronica Verdile, Veronica Riccioni, Marika Guerra, Gabriele Ferrante, Claudio Sette, Cristiana Valle, Alberto Ferri, Maria Paola Paronetto
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons, leading to paralysis and death. Dysregulation of synaptic structure and function has been identified as a pathogenic feature of ALS. Alternative pre-mRNA splicing (AS) is associated with synapse formation and functional specification and exploring its link with ALS could lead to new therapeutic opportunities.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Veronica Lisi, Chantalle Moulton, Cristina Fantini, Elisa Grazioli, Flavia Guidotti, Paolo Sgro, Ivan Dimauro, Laura Capranica, Attilio Parisi, Luigi Di Luigi, Daniela Caporossi
Summary: This study investigates the role of redox homeostasis in exercise-induced signaling and adaptation, with a focus on the intercellular communication of redox status mediated by circulating extracellular vesicles (EVs). The findings suggest that aerobic capacity and short-term aerobic training can impact the redox status of circulating EVs, highlighting the potential use of EVs as biomarkers for assessing exercise efficacy and oxidative-stress related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Green & Sustainable Science & Technology
Flavia Guidotti, Sabrina Demarie, Simone Ciaccioni, Laura Capranica
Summary: The purpose of this study was to test the validity of a Sports Management framework and explore the managers' perceived relevance, possession, and need for training of knowledge, competencies, and skills. Focus groups with sports managers were organized to test the framework's validity and assess the managers' perceptions. The findings showed good validity, internal consistency, and a high consensus agreement, highlighting the importance of soft skills in the sports management profession.
Review
Oncology
Valentina Frezza, Lidia Chellini, Arianna Del Verme, Maria Paola Paronetto
Summary: Recent evidence has shown that RNA editing, in addition to somatic mutations and alternative splicing changes, plays a significant role in altering genetic information in a dynamic fashion. This form of post-transcriptional RNA modification is closely associated with the development of various human diseases, including cancer, by regulating various cellular processes. Studies on the impact of RNA editing in cancer transformation are gaining increasing interest, particularly in relation to cell proliferation, differentiation, invasion, stemness, and drug resistance.
Article
Biochemistry & Molecular Biology
Lidia Chellini, Marzia Scarfo, Davide Bonvissuto, Claudio Sette, Maria Paola Paronetto
Summary: In this study, researchers found that the DHX9/KDM2B complex can serve as a new drug target for treating aggressive Ewing sarcoma. By regulating the expression of the Hippo pathway regulator YAP1, this complex can influence the oncogenic properties of Ewing sarcoma cells.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)