标题
Lactate in the tumour microenvironment: From immune modulation to therapy
作者
关键词
Lactate, Glycolytic enzymes, Monocarboxylate transporters, Cancer metabolism, Cancer immunity, Tumour microenvironment
出版物
EBioMedicine
Volume 73, Issue -, Pages 103627
出版商
Elsevier BV
发表日期
2021-10-15
DOI
10.1016/j.ebiom.2021.103627
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
- (2021) McLane J. Watson et al. NATURE
- Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine‐modifying inhibitors
- (2021) Anna‐Lena Köpnick et al. FEBS Journal
- Targeting neovascularization and respiration of tumor grafts grown on chick embryo chorioallantoic membranes
- (2021) Hyrije Ademi et al. PLoS One
- LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma
- (2021) Xiukun Hou et al. Cell Death & Disease
- Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model
- (2021) Tianyun Qiao et al. Frontiers in Oncology
- Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL).
- (2021) Sarah E. R. Halford et al. JOURNAL OF CLINICAL ONCOLOGY
- Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)
- (2021) Masaki Kobayashi et al. PHARMACOLOGY & THERAPEUTICS
- Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
- (2020) Sicheng Fu et al. Nature Communications
- Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype
- (2020) Léa Paolini et al. Cancer Immunology Research
- Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy
- (2020) Chung-Yu Huang et al. Cancers
- Tumor‐Targeted Inhibition of Monocarboxylate Transporter 1 Improves T‐Cell Immunotherapy of Solid Tumors
- (2020) Tongyi Huang et al. Advanced Healthcare Materials
- Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells
- (2020) Fernando Erra Díaz et al. Cell Reports
- Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation
- (2020) Vera Miranda-Gonçalves et al. Cells
- Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism
- (2020) Jérôme Ruhnau et al. BMC CANCER
- Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds
- (2020) Giovanna Li Petri et al. BRITISH JOURNAL OF CANCER
- Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment
- (2020) Eleonora Vitali et al. Cancers
- AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy
- (2020) Dorota K Flak et al. International Journal of Nanomedicine
- Targeting lactate dehydrogenase A ( LDHA ) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia
- (2020) Haizhi Yu et al. Cancer Communications
- Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors
- (2020) Marjolein M.G. Kes et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates
- (2020) Nan Wang et al. CELL
- Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter
- (2020) Shivendra Vikram Singh et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells
- (2019) Xiaowen Guan et al. AAPS Journal
- Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis
- (2019) G. Comito et al. ONCOGENE
- Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer
- (2019) Yoshihiro Hayashi et al. CANCER SCIENCE
- Microenvironmental Metabolism Regulates Antitumor Immunity
- (2019) Verra M. Ngwa et al. CANCER RESEARCH
- Targeting mTOR for cancer therapy
- (2019) Hui Hua et al. Journal of Hematology & Oncology
- Monocarboxylate transporters in cancer
- (2019) Valéry L. Payen et al. Molecular Metabolism
- Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells
- (2019) Deblina Raychaudhuri et al. Frontiers in Immunology
- Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer
- (2019) Goran Hamid Mohammad et al. Cancers
- Metabolic regulation of gene expression by histone lactylation
- (2019) Di Zhang et al. NATURE
- Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
- (2019) Kathrin Renner et al. Cell Reports
- Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring
- (2019) Valentina Pucino et al. Cell Metabolism
- Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon
- (2019) Timothy P. Brown et al. PHARMACOLOGY & THERAPEUTICS
- Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
- (2018) Zandra E. Walton et al. CELL
- The Science and Translation of Lactate Shuttle Theory
- (2018) George A. Brooks Cell Metabolism
- Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
- (2018) Thomas M. Ashton et al. CLINICAL CANCER RESEARCH
- Lactate metabolism: historical context, prior misinterpretations, and current understanding
- (2018) Brian S. Ferguson et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
- (2018) Cyril Corbet et al. Nature Communications
- The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging
- (2018) Mohammed Albatany et al. INVESTIGATIONAL NEW DRUGS
- Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism
- (2018) Maša Ždralević et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
- (2018) Maria Quanz et al. MOLECULAR CANCER THERAPEUTICS
- Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression
- (2018) Na Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
- (2018) Yangbo Feng et al. Cancer Medicine
- Lactate: A Metabolic Driver in the Tumour Landscape
- (2018) Luigi Ippolito et al. TRENDS IN BIOCHEMICAL SCIENCES
- Programmed cell death-1 (PD-1) checkpoint blockade in combination with a mammalian target of rapamycin inhibitor restrains hepatocellular carcinoma growth induced by hepatoma cell-intrinsic PD-1
- (2017) Hui Li et al. HEPATOLOGY
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- Lactic Acid: No Longer an Inert and End-Product of Glycolysis
- (2017) Shiren Sun et al. PHYSIOLOGY
- Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
- (2017) Peiwen Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting pH regulating proteins for cancer therapy–Progress and limitations
- (2017) Scott K. Parks et al. SEMINARS IN CANCER BIOLOGY
- Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
- (2017) Lindsay Wilde et al. SEMINARS IN ONCOLOGY
- Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death
- (2017) Zheng-Wei Lee et al. Frontiers in Pharmacology
- The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters
- (2016) B. Nancolas et al. BIOCHEMICAL JOURNAL
- Monocarboxylate transporters in the brain and in cancer
- (2016) Jhudit Pérez-Escuredo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
- (2016) Aaron Boudreau et al. Nature Chemical Biology
- Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling
- (2016) Di Xie et al. Science China-Life Sciences
- Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells
- (2015) Ricardo Amorim et al. CANCER LETTERS
- Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt–mTOR signaling pathway
- (2015) Zhi Zhao et al. CANCER LETTERS
- Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs
- (2015) Y. D. Bhutia et al. CANCER RESEARCH
- Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy
- (2015) Reshma Rani et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma
- (2015) Giselle L. Saulnier Sholler et al. PLoS One
- Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
- (2015) Robert Haas et al. PLOS BIOLOGY
- HIF-1α pathway: role, regulation and intervention for cancer therapy
- (2015) Georgina N. Masoud et al. Acta Pharmaceutica Sinica B
- Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux
- (2014) N. Draoui et al. MOLECULAR CANCER THERAPEUTICS
- Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
- (2014) Ubaldo E. Martinez-Outschoorn et al. SEMINARS IN CANCER BIOLOGY
- Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
- (2013) M Maftouh et al. BRITISH JOURNAL OF CANCER
- Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway
- (2013) Zhiqiang Zhao et al. CANCER LETTERS
- Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
- (2013) R. Polanski et al. CLINICAL CANCER RESEARCH
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
- (2013) Zhen Yang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid
- (2013) A. Nasi et al. JOURNAL OF IMMUNOLOGY
- Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
- (2013) Zaheed Husain et al. OncoImmunology
- Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells
- (2012) Luigi Fiume et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
- (2012) F. Farabegoli et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
- (2012) Tom Latham et al. NUCLEIC ACIDS RESEARCH
- Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
- (2011) Hiroto Izumi et al. CANCER SCIENCE
- Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase
- (2011) Marcella Manerba et al. ChemMedChem
- Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
- (2011) Anna N. Mendler et al. INTERNATIONAL JOURNAL OF CANCER
- Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells
- (2011) Carlotta Granchi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic targeting of cancer cell metabolism
- (2011) Chi V. Dang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- (2011) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential activation and antagonistic function of HIF- isoforms in macrophages are essential for NO homeostasis
- (2010) N. Takeda et al. GENES & DEVELOPMENT
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
- (2008) B. Clem et al. MOLECULAR CANCER THERAPEUTICS
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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