Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates
出版年份 2020 全文链接
标题
Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates
作者
关键词
SLC transporters, lactate transport, monocarboxylate transporter, MCT, Basigin/CD147, proton coupling, alternating access, cryo-EM, AZD3965, BAY-8002, 7ACC2
出版物
CELL
Volume 184, Issue 2, Pages 370-383.e13
出版商
Elsevier BV
发表日期
2020-12-17
DOI
10.1016/j.cell.2020.11.043
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cooperative transport mechanism of human monocarboxylate transporter 2
- (2020) Bo Zhang et al. Nature Communications
- Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex
- (2019) Renhong Yan et al. NATURE
- Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport
- (2019) Jonathan A. Coleman et al. NATURE
- Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
- (2019) Yongchan Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
- (2019) Patrick D. Bosshart et al. Nature Communications
- Monocarboxylate transporters in cancer
- (2019) Valéry L. Payen et al. Molecular Metabolism
- Structure and drug resistance of the Plasmodium falciparum transporter PfCRT
- (2019) Jonathan Kim et al. NATURE
- The Science and Translation of Lactate Shuttle Theory
- (2018) George A. Brooks Cell Metabolism
- Real-space refinement in PHENIX for cryo-EM and crystallography
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
- (2018) Maria Quanz et al. MOLECULAR CANCER THERAPEUTICS
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
- (2017) Nicola J. Curtis et al. Oncotarget
- Monocarboxylate transporters in the brain and in cancer
- (2016) Jhudit Pérez-Escuredo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Structure of a yeast activated spliceosome at 3.5 A resolution
- (2016) C. Yan et al. SCIENCE
- Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
- (2016) Laura Pisarsky et al. Cell Reports
- Structural Biology of the Major Facilitator Superfamily Transporters
- (2015) Nieng Yan Annual Review of Biophysics
- Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity: Figure 6
- (2015) B. Nancolas et al. BIOCHEMICAL JOURNAL
- Monocarboxylate Transporter 1 Deficiency and Ketone Utilization
- (2015) NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport
- (2014) B. M. Bola et al. MOLECULAR CANCER THERAPEUTICS
- Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux
- (2014) N. Draoui et al. MOLECULAR CANCER THERAPEUTICS
- Crystal structure of the human glucose transporter GLUT1
- (2014) Dong Deng et al. NATURE
- Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies
- (2014) Katherine E. Wright et al. NATURE
- Structure of the Yeast Mitochondrial Large Ribosomal Subunit
- (2014) A. Amunts et al. SCIENCE
- Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells
- (2013) Nihed Draoui et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- The SLC16 gene family – Structure, role and regulation in health and disease
- (2013) Andrew P. Halestrap MOLECULAR ASPECTS OF MEDICINE
- Crystal structure of a bacterial homologue of glucose transporters GLUT1–4
- (2012) Linfeng Sun et al. NATURE
- Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
- (2012) Pierre Sonveaux et al. PLoS One
- Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells
- (2012) Christophe J. De Saedeleer et al. PLoS One
- Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis
- (2011) F. Vegran et al. CANCER RESEARCH
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Evidence for a stromal-epithelial “lactate shuttle” in human tumors
- (2011) Diana Whitaker-Menezes et al. CELL CYCLE
- The monocarboxylate transporter family-Role and regulation
- (2011) Andrew P. Halestrap et al. IUBMB LIFE
- The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
- (2010) Matthew J. Ovens et al. BIOCHEMICAL JOURNAL
- I-TASSER: a unified platform for automated protein structure and function prediction
- (2010) Ambrish Roy et al. Nature Protocols
- AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10
- (2009) Matthew J. Ovens et al. BIOCHEMICAL JOURNAL
- Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle
- (2009) Marieangela C. Wilson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes
- (2009) K. Dietl et al. JOURNAL OF IMMUNOLOGY
- Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer
- (2008) Vadivel Ganapathy et al. AAPS Journal
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started