标题
Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development
作者
关键词
-
出版物
Frontiers in Chemistry
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-02-03
DOI
10.3389/fchem.2021.819165
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
- (2021) Ziyang Fu et al. Nature Communications
- Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
- (2021) Jerzy Osipiuk et al. Nature Communications
- Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
- (2021) Ewelina Weglarz-Tomczak et al. Scientific Reports
- Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19
- (2021) Kas Steuten et al. ACS Infectious Diseases
- Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations
- (2021) Chun-Hui Zhang et al. ACS Central Science
- An update review of emerging small-molecule therapeutic options for COVID-19
- (2021) Dengke Tian et al. BIOMEDICINE & PHARMACOTHERAPY
- Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease
- (2021) Navaneethakrishnan Krishnamoorthy et al. IUBMB LIFE
- Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors
- (2021) Naoya Kitamura et al. JOURNAL OF MEDICINAL CHEMISTRY
- X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
- (2021) Sebastian Günther et al. SCIENCE
- High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
- (2021) Yao Zhao et al. Protein & Cell
- SARS-CoV-2 Mpro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors
- (2021) Andrea Citarella et al. Biomolecules
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease
- (2021) Chew Theng Lim et al. BIOCHEMICAL JOURNAL
- Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations
- (2021) Bilal Ahmad et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
- (2021) Kangsa Amporndanai et al. Nature Communications
- A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
- (2021) Stephanie Patchett et al. Cell Reports
- Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay
- (2021) Chunlong Ma et al. ACS Central Science
- Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
- (2021) Wayne Vuong et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease
- (2021) Yunxia Xu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
- (2021) Dafydd R. Owen et al. SCIENCE
- Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays
- (2021) Chunlong Ma et al. Acta Pharmaceutica Sinica B
- 6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro
- (2021) Caleb D. Swaim et al. iScience
- The continuous rediscovery and the benefit–risk ratio of thioguanine, a comprehensive review
- (2020) Ahmed B. Bayoumy et al. Expert Opinion on Drug Metabolism & Toxicology
- α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
- (2020) Linlin Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Architecture of SARS-CoV-2 Transcriptome
- (2020) Dongwan Kim et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
- (2020) Arun K. Ghosh et al. ChemMedChem
- Structural and Evolutionary Analysis Indicate That the SARS-CoV-2 Mpro Is a Challenging Target for Small-Molecule Inhibitor Design
- (2020) Maria Bzówka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
- (2020) Zhenming Jin et al. NATURE
- Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
- (2020) Zhenming Jin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cell entry mechanisms of SARS-CoV-2
- (2020) Jian Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
- (2020) Wenhao Dai et al. SCIENCE
- Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
- (2020) Linlin Zhang et al. SCIENCE
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- (2020) Timothy P. Sheahan et al. Science Translational Medicine
- Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy
- (2020) Bhupesh Goyal et al. ACS Combinatorial Science
- Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease
- (2020) Brendan T Freitas et al. ACS Infectious Diseases
- Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
- (2020) Chunlong Ma et al. CELL RESEARCH
- Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses
- (2020) Rajanish Giri et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The Development of Coronavirus 3C-Like Protease (3CLpro) Inhibitors from 2010 to 2020
- (2020) Yuzhi Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)
- (2020) Jamie A. Kelly et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
- (2020) Donghyuk Shin et al. NATURE
- Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography
- (2020) Daniel W. Kneller et al. Nature Communications
- TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
- (2020) Dorothea Bestle et al. Life Science Alliance
- Sequence Characterization and Molecular Modeling of Clinically Relevant Variants of the SARS-CoV-2 Main Protease
- (2020) Thomas J. Cross et al. BIOCHEMISTRY
- Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
- (2020) Theresa Klemm et al. EMBO JOURNAL
- Unusual zwitterionic catalytic site of SARS-CoV-2 main protease revealed by neutron crystallography
- (2020) Daniel W. Kneller et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Impact of Early Pandemic Stage Mutations on Molecular Dynamics of SARS-CoV-2 Mpro
- (2020) Olivier Sheik Amamuddy et al. Journal of Chemical Information and Modeling
- Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
- (2020) Robert L. Hoffman et al. JOURNAL OF MEDICINAL CHEMISTRY
- SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging
- (2020) Wioletta Rut et al. Nature Chemical Biology
- Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource
- (2020) Stephanie Portelli et al. NATURE GENETICS
- REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
- (2020) Alina Baum et al. SCIENCE
- Coronavirus Antiviral Research Database (CoV-RDB): An Online Database Designed to Facilitate Comparisons between Candidate Anti-Coronavirus Compounds
- (2020) Philip L. Tzou et al. Viruses-Basel
- Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
- (2020) Lifeng Fu et al. Nature Communications
- Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
- (2020) Wayne Vuong et al. Nature Communications
- Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL Mpro: insights into enzyme mechanism and drug design
- (2020) Daniel W. Kneller et al. IUCrJ
- Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
- (2020) Wioletta Rut et al. Science Advances
- Crystal structure of SARS-CoV-2 papain-like protease
- (2020) Xiaopan Gao et al. Acta Pharmaceutica Sinica B
- High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2
- (2020) Emery Smith et al. SLAS Discovery
- Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors
- (2020) Sk. Abdul Amin et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Potential SARS-CoV-2 main protease inhibitors
- (2020) Riddhidev Banerjee et al. DRUG DISCOVERY TODAY
- Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease
- (2019) Jozlyn R. Clasman et al. ANTIVIRAL RESEARCH
- Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
- (2018) Jian Lei et al. ANTIVIRAL RESEARCH
- Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
- (2018) Min-Han Lin et al. ANTIVIRAL RESEARCH
- ISG15 in antiviral immunity and beyond
- (2018) Yi-Chieh Perng et al. NATURE REVIEWS MICROBIOLOGY
- Crystal structure of a human ubiquitin E1–ubiquitin complex reveals conserved functional elements essential for activity
- (2018) Zongyang Lv et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur
- (2018) Alexey Dementiev et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
- (2017) Dustin Siegel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species
- (2017) Courtney M. Daczkowski et al. JOURNAL OF MOLECULAR BIOLOGY
- S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity
- (2017) Zongyang Lv et al. MOLECULAR CELL
- Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
- (2017) Marcin Poreba et al. Nature Protocols
- Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
- (2017) Lingmin Yuan et al. Nature Communications
- An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy
- (2016) Thanigaimalai Pillaiyar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease
- (2016) Miklós Békés et al. MOLECULAR CELL
- Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
- (2016) Travis K. Warren et al. NATURE
- The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
- (2015) Yahira M. Báez-Santos et al. ANTIVIRAL RESEARCH
- Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus
- (2015) Kai-Wen Cheng et al. ANTIVIRAL RESEARCH
- From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
- (2014) Rolf Hilgenfeld FEBS Journal
- X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
- (2014) Yahira M. Báez-Santos et al. JOURNAL OF MEDICINAL CHEMISTRY
- Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus
- (2014) Y. M. Baez-Santos et al. JOURNAL OF VIROLOGY
- Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
- (2014) Gajendra Kumar Azad et al. MOLECULAR BIOLOGY REPORTS
- Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
- (2014) Anna M. Mielech et al. VIRUS RESEARCH
- Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
- (2014) Kiira Ratia et al. PLoS Pathogens
- Structural basis for catalysis and ubiquitin recognition by theSevere acute respiratory syndrome coronaviruspapain-like protease
- (2014) Chi-Yuan Chou et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- The Ubiquitin Code
- (2012) David Komander et al. Annual Review of Biochemistry
- Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
- (2012) Ji-Young Park et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
- (2012) Jon Jacobs et al. JOURNAL OF MEDICINAL CHEMISTRY
- Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation
- (2010) Arun K. Ghosh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Coronavirus Genomics and Bioinformatics Analysis
- (2010) Patrick C. Y. Woo et al. Viruses-Basel
- Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease
- (2009) Arun K. Ghosh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Enzyme Catalysis by Hydrogen Bonds: The Balance between Transition State Binding and Substrate Binding in Oxyanion Holes
- (2009) Luis Simón et al. JOURNAL OF ORGANIC CHEMISTRY
- Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
- (2008) Marcin Drag et al. BIOCHEMICAL JOURNAL
- Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus
- (2008) Chi-Yuan Chou et al. BIOCHEMICAL PHARMACOLOGY
- Shared Principles in NF-κB Signaling
- (2008) Matthew S. Hayden et al. CELL
- A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
- (2008) K. Ratia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now