Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

(2014) Jian Lei et al.   ANTIVIRAL RESEARCH

X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

(2014) Yahira M. Báez-Santos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?

(2014) Emmanuel Faure et al.   PLoS One

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

(2014) Anna M. Mielech et al.   VIRUS RESEARCH

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease

(2014) Kiira Ratia et al.   PLoS Pathogens

Structural basis for catalysis and ubiquitin recognition by theSevere acute respiratory syndrome coronaviruspapain-like protease

(2014) Chi-Yuan Chou et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa

(2013) Jung Keun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synergistic Inhibitor Binding to the Papain-Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications

(2013) Hyun Lee et al.   ChemMedChem

Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013

(2013) R Perera et al.   Eurosurveillance

Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds ofPsoralea corylifolia

(2013) Dae Wook Kim et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors

(2013) A. Kilianski et al.   JOURNAL OF VIROLOGY

Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study

(2013) Matthew Cotten et al.   LANCET

Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk

(2013) Romulus Breban et al.   LANCET

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

(2013) Chantal BEM Reusken et al.   LANCET INFECTIOUS DISEASES

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells

(2013) Puck B. van Kasteren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

(2013) Anna M. Mielech et al.   VIROLOGY

Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential

(2013) E. Kindler et al.   mBio

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

No novel coronaviruses identified in a large collection of human nasopharyngeal specimens using family-wide CODEHOP-based primers

(2012) Kalina T. Zlateva et al.   ARCHIVES OF VIROLOGY

Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?

(2012) Jasper F.W. Chan et al.   JOURNAL OF INFECTION

Clusters of coronavirus cases put scientists on alert

(2012) Declan Butler   NATURE

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

(2012) Li Sun et al.   PLoS One

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

(2012) S. van Boheemen et al.   mBio

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

(2012) Allison L Totura et al.   Current Opinion in Virology

Comparison of SARS and NL63 Papain-Like Protease Binding Sites and Binding Site Dynamics: Inhibitor Design Implications

(2011) Rima Chaudhuri et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway

(2011) Gang Wang et al.   PLoS One

Yeast Based Small Molecule Screen for Inhibitors of SARS-CoV

(2011) Matthew Frieman et al.   PLoS One

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

(2010) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

(2010) M. A. Clementz et al.   JOURNAL OF VIROLOGY

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease

(2009) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF- B Signaling

(2009) M. Frieman et al.   JOURNAL OF VIROLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

(2009) R. Z. Cer et al.   NUCLEIC ACIDS RESEARCH

Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

(2008) Chi-Yuan Chou et al.   BIOCHEMICAL PHARMACOLOGY

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

(2008) Dahai Zheng et al.   CELL RESEARCH

Proteomics Analysis Unravels the Functional Repertoire of Coronavirus Nonstructural Protein 3

(2008) B. W. Neuman et al.   JOURNAL OF VIROLOGY

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

(2008) K. Ratia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA