Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease—From Bench to Bedside

NAD + Repletion Reverses Heart Failure with Preserved Ejection Fraction

(2021) Dan Tong et al.   CIRCULATION RESEARCH

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

(2021) Mihoko Yoshino et al.   SCIENCE

Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity

(2021) David M Cartwright et al.   JOURNAL OF ENDOCRINOLOGY

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis – Central role of macrophage scavenger receptor 1

(2020) Tasneem Arsiwala et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation

(2020) Shu Song et al.   ACTA PHARMACOLOGICA SINICA

NAD+ administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux

(2020) You-Jun Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Implications of NAD + boosters in translational medicine

(2020) Baeki E. Kang et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Depot-specific regulation of NAD+/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction

(2020) Xiaojing Wei et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling

(2020) Qin Tang et al.   Molecular Metabolism

Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure

(2020) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

(2020) Milton Packer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes

(2020) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT6 Protects Smooth Muscle Cells from Senescence and Reduces Atherosclerosis

(2020) Mandy Grootaert et al.   CIRCULATION RESEARCH

Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease

(2020) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

(2020) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model

(2019) Yin Ying et al.   Aging-US

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial

(2019) Mohapradeep Mohan et al.   EUROPEAN HEART JOURNAL

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

(2019) Abhinav Kanwal et al.   FASEB JOURNAL

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

(2019) Stefano Tarantini et al.   Redox Biology

Response by Pfeffer et al to Letter Regarding Article, “Heart Failure With Preserved Ejection Fraction in Perspective”

(2019) Marc A. Pfeffer et al.   CIRCULATION RESEARCH

Effects of nicotinamide riboside on endocrine pancreatic function and incretin hormones in obese, non-diabetic men

(2019) Ole L Dollerup et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes

(2019) Kuan Yang et al.   JOURNAL OF IMMUNOLOGY

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

(2019) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

(2019) Yasir S. Elhassan et al.   Cell Reports

Inhibition Of Mitochondrial Calcium Overload By SIRT3 Prevents Obesity Or Age-Related Whitening Of Brown Adipose Tissue

(2019) Peng Gao et al.   DIABETES

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

(2019) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats

(2019) Myat Theingi Swe et al.   CLINICAL SCIENCE

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression

(2018) Tingting Feng et al.   ATHEROSCLEROSIS

A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKA y mice

(2018) Peng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance

(2018) Rui Fan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation

(2018) Penghao Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

(2018) Daniel S Gaul et al.   CARDIOVASCULAR RESEARCH

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH

(2018) Sergiy M. Nadtochiy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection

(2018) Hiroyuki Umino et al.   Scientific Reports

Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition

(2018) Sai Ma et al.   Oxidative Medicine and Cellular Longevity

Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2018) Melanie J. Davies et al.   DIABETES CARE

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

(2018) Stephen D. Wiviott et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

(2018) Elisabet Cuyàs et al.   Frontiers in Endocrinology

Caloric restriction ameliorates cardiomyopathy in animal model of diabetes

(2017) Keren Cohen et al.   EXPERIMENTAL CELL RESEARCH

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

(2017) Javier Traba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

(2017) Bruce Neal et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

(2017) Nicolas Diguet et al.   CIRCULATION

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion

(2016) Tsunehisa Yamamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

(2016) Stephan Winnik et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

(2016) Wen Yang et al.   CELL

Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective

(2016) Chi Fung Lee et al.   CIRCULATION

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

(2016) Simon A. Hawley et al.   DIABETES

NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy

(2016) Zhongbao Yue et al.   EXPERIMENTAL CELL RESEARCH

Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis

(2016) Bruce E. Sands et al.   INFLAMMATORY BOWEL DISEASES

Calorie restriction protects against experimental abdominal aortic aneurysms in mice

(2016) Yue Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diet-induced obesity and insulin resistance are associated with brown fat degeneration in SIRT1-deficient mice

(2016) Fen Xu et al.   Obesity

Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice

(2016) Zhiping Liu et al.   Translational Research

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

(2016) Joanna Ratajczak et al.   Nature Communications

Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner

(2015) N Preyat et al.   CELL DEATH AND DIFFERENTIATION

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

(2015) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

(2015) Duanfang Cao et al.   GENES & DEVELOPMENT

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

(2015) S. Vigili de Kreutzenberg et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Empagliflozin in the treatment of type 2 diabetes: evidence to date

(2015) Jay Shubrook et al.   Drug Design Development and Therapy

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

(2015) James G. Krueger et al.   PLoS One

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes

(2014) Arun Baksi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

SnapShot: Sirtuins, NAD, and Aging

(2014) Takashi Nakagawa et al.   Cell Metabolism

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

(2014) Melroy X. Miranda et al.   EUROPEAN HEART JOURNAL

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

(2014) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

(2014) Takanobu Yamamoto et al.   PLoS One

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

(2014) Pénélope A. Andreux et al.   Scientific Reports

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

(2013) Stephan Winnik et al.   BASIC RESEARCH IN CARDIOLOGY

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory: Bringing All the Strands Together

(2013) F. Paneni et al.   DIABETES

Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes

(2013) Soo Jin Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Post-Translational Modification of Mitochondrial Proteins by Caloric Restriction: Possible Involvement in Caloric Restriction-Induced Cardioprotection

(2013) Ken Shinmura   TRENDS IN CARDIOVASCULAR MEDICINE

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers

(2013) Sowmya Venkatasubramanian et al.   Journal of the American Heart Association

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Sirtuins: NAD+-dependent deacetylase mechanism and regulation

(2012) Anthony A Sauve et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Exploring the therapeutic space around NAD+

(2012) Riekelt H. Houtkooper et al.   JOURNAL OF CELL BIOLOGY

Mitochondria of trained skeletal muscle are protected from deleterious effects of statins

(2012) Jamal Bouitbir et al.   MUSCLE & NERVE

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT1-mediated acute cardioprotection

(2011) Sergiy M. Nadtochiy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells

(2010) Alexander Breitenstein et al.   CARDIOVASCULAR RESEARCH

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

(2010) Chiao-Po Hsu et al.   CIRCULATION

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

(2010) Sokrates Stein et al.   EUROPEAN HEART JOURNAL

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH