NAD+ administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury

(2019) Sean M. Davidson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardioprotection Beyond Infarct Size Reduction

(2019) Gerd Heusch et al.   CIRCULATION RESEARCH

FoxO1 inhibits autophagosome-lysosome fusion leading to endothelial autophagic-apoptosis in diabetes

(2019) Hui Zhang et al.   CARDIOVASCULAR RESEARCH

Optimized Treatment of ST-Elevation Myocardial Infarction

(2019) Giampaolo Niccoli et al.   CIRCULATION RESEARCH

Coronary microvascular obstruction: the new frontier in cardioprotection

(2019) Gerd Heusch   BASIC RESEARCH IN CARDIOLOGY

Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats

(2019) Leila Hosseini et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Guidelines for experimental models of myocardial ischemia and infarction

(2018) Merry L. Lindsey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic AngiogenesisNovelty and Significance

(2018) Yanbo Fan et al.   CIRCULATION RESEARCH

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH

(2018) Sergiy M. Nadtochiy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ischemic preconditioning attenuates ischemia/reperfusion-induced kidney injury by activating autophagy via the SGK1 signaling pathway

(2018) Ying Xie et al.   Cell Death & Disease

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

(2018) Hans Erik Bøtker et al.   BASIC RESEARCH IN CARDIOLOGY

Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia

(2018) Yueyang Liu et al.   Autophagy

Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials

(2017) Suzanne de Waha et al.   EUROPEAN HEART JOURNAL

Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection

(2017) Youngil Lee et al.   Journal of Physiological Sciences

Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy

(2017) Derong Cui et al.   Cell Death & Disease

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species

(2016) Andrew O. Kadlec et al.   BASIC RESEARCH IN CARDIOLOGY

The Coronary Circulation as a Target of Cardioprotection

(2016) Gerd Heusch   CIRCULATION RESEARCH

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

(2016) Gerd Heusch et al.   EUROPEAN HEART JOURNAL

The potential regulatory roles of NAD+ and its metabolism in autophagy

(2016) Dong-Xia Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

(2015) Rebecca J Godar et al.   Autophagy

Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning

(2015) G. Heusch   CIRCULATION RESEARCH

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Extracellular signalling molecules in the ischaemic/reperfused heart - druggable and translatable for cardioprotection?

(2014) P Kleinbongard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene

(2014) Yang Zhang et al.   CARDIOVASCULAR RESEARCH

Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy

(2014) Min Xie et al.   CIRCULATION

No Evidence for Activated Autophagy in Left Ventricular Myocardium at Early Reperfusion with Protection by Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting

(2014) Nilgün Gedik et al.   PLoS One

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

(2014) Takanobu Yamamoto et al.   PLoS One

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Homeostatic Intracellular Repair Response During Cardiac Surgery

(2013) Salik M. Jahania et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Autophagy is impaired in cardiac ischemia-reperfusion injury

(2012) Xiucui Ma et al.   Autophagy

Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

(2012) Xiucui Ma et al.   CIRCULATION

The coronary circulation in cardioprotection: more than just one confounder

(2011) G. Heusch et al.   CARDIOVASCULAR RESEARCH

Protection Against Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Angiopoietin-Like 4

(2011) Ariane Galaup et al.   CIRCULATION

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE