Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation

Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism

(2021) Sandra Nitsch et al.   EMBO REPORTS

Alternatively activated macrophages promote resolution of necrosis following acute liver injury

(2020) Philip Starkey Lewis et al.   JOURNAL OF HEPATOLOGY

17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB

(2020) Zhiheng Sun et al.   Frontiers in Immunology

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

(2019) Min Yuan et al.   Nature Protocols

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer

(2018) Harvey R. Fernandez et al.   CELL DEATH AND DIFFERENTIATION

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Anti-thrombotic and pro-angiogenic effects of Rubia cordifolia extract in zebrafish

(2018) Yi Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

(2018) Julian Hlouschek et al.   Frontiers in Oncology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

(2018) Saul Soberanes et al.   Cell Metabolism

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

(2017) Monika Linke et al.   FEBS LETTERS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Epigenetic regulation of the glucose transporter geneSlc2a1by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice

(2016) Kosuke Tanegashima et al.   GENES TO CELLS

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Zebrafish Thrombosis Model for Assessing Antithrombotic Drugs

(2016) Xiao-Yu Zhu et al.   Zebrafish

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry

(2015) Jun Han et al.   ANALYTICA CHIMICA ACTA

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

(2015) Vamsi K. Kolukula et al.   Oncotarget

A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation

(2014) Vittoria Infantino et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Molecular dialogs between the ischemic brain and the peripheral immune system: Dualistic roles in injury and repair

(2014) Chengrui An et al.   PROGRESS IN NEUROBIOLOGY

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

β-glucan recognition by the innate immune system

(2009) Helen S. Goodridge et al.   IMMUNOLOGICAL REVIEWS

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells

(2008) David Saggerson   Annual Review of Nutrition

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Minireview: The PGC-1 Coactivator Networks: Chromatin-Remodeling and Mitochondrial Energy Metabolism

(2008) Jiandie D. Lin   MOLECULAR ENDOCRINOLOGY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE