Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism

Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells

(2021) Yi Fang et al.   Cell Stem Cell

Live-cell epigenome manipulation by synthetic histone acetylation catalyst system

(2021) Yusuke Fujiwara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of functional disordered regions within chromatin associated proteins

(2021) Catherine A. Musselman et al.   iScience

Succinylation of H3K122 destabilizes nucleosomes and enhances transcription

(2021) Lara Zorro Shahidian et al.   EMBO REPORTS

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Subcellular Mass Spectrometry Imaging and Absolute Quantitative Analysis across Organelles

(2020) Aurélien Thomen et al.   ACS Nano

Bottom-Up Meets Top-Down: The Crossroads of Multiscale Chromatin Modeling

(2020) Joshua Moller et al.   BIOPHYSICAL JOURNAL

Metabolism and the Epigenome: A Dynamic Relationship

(2020) Spencer A. Haws et al.   TRENDS IN BIOCHEMICAL SCIENCES

Semisynthesis of site-specifically succinylated histone reveals that succinylation regulates nucleosome unwrapping rate and DNA accessibility

(2020) Yihang Jing et al.   NUCLEIC ACIDS RESEARCH

Biomolecular Condensates in the Nucleus

(2020) Benjamin R. Sabari et al.   TRENDS IN BIOCHEMICAL SCIENCES

The evolving metabolic landscape of chromatin biology and epigenetics

(2020) Ziwei Dai et al.   NATURE REVIEWS GENETICS

Quantification of the effect of site-specific histone acetylation on chromatin transcription rate

(2020) Masatoshi Wakamori et al.   NUCLEIC ACIDS RESEARCH

Identification of lysine isobutyrylation as a new histone modification mark

(2020) Zhesi Zhu et al.   NUCLEIC ACIDS RESEARCH

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses

(2020) Ryan Houston et al.   PLOS BIOLOGY

Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription

(2019) Claire E. Barnes et al.   Essays in Biochemistry

Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo

(2019) Jason Otterstrom et al.   NUCLEIC ACIDS RESEARCH

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

(2019) Xingrun Zhang et al.   Cell Discovery

Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics

(2019) Xiucong Bao et al.   MOLECULAR CELL

Controlling the material properties and rRNA processing function of the nucleolus using light

(2019) Lian Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins

(2019) Simone Sidoli et al.   Scientific Reports

Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression

(2019) Graeme J. Gowans et al.   MOLECULAR CELL

Formation of Chromatin Subcompartments by Phase Separation

(2018) Fabian Erdel et al.   BIOPHYSICAL JOURNAL

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

(2018) He Huang et al.   MOLECULAR CELL

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress

(2018) Alec G. Trub et al.   TRENDS IN BIOCHEMICAL SCIENCES

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

(2018) Sharanya Sivanand et al.   TRENDS IN BIOCHEMICAL SCIENCES

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins

(2018) Tadashi Ishiguro et al.   Scientific Reports

Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles

(2018) Diana M. Mitrea et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysine benzoylation is a histone mark regulated by SIRT2

(2018) He Huang et al.   Nature Communications

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

(2018) Yongdae Shin et al.   CELL

Beyond histone acetylation—writing and erasing histone acylations

(2018) Shuai Zhao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis

(2017) Shumeng Liu et al.   MOLECULAR CELL

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

(2017) Yugang Wang et al.   NATURE

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

(2017) Olivier Cuvier et al.   NATURE REVIEWS GENETICS

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of histone acylations links chromatin modifications with metabolism

(2017) Johayra Simithy et al.   Nature Communications

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

(2016) Afsaneh Goudarzi et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

Structure of p300 in complex with acyl-CoA variants

(2016) Zuzanna Kaczmarska et al.   Nature Chemical Biology

Genetic code expansion in stable cell lines enables encoded chromatin modification

(2016) Simon J Elsässer et al.   NATURE METHODS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription

(2016) Aristeidis E. Boukouris et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

(2016) Diana M Mitrea et al.   eLife

Uncovering the forces between nucleosomes using DNA origami

(2016) J. J. Funke et al.   Science Advances

Genetically Encoding Lysine Modifications on Histone H4

(2015) Bryan J. Wilkins et al.   ACS Chemical Biology

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study

(2015) Rosana Collepardo-Guevara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

(2015) E. Megan Flynn et al.   STRUCTURE

Crafting the Brain – Role of Histone Acetyltransferases in Neural Development and Disease

(2014) Bilal N. Sheikh   CELL AND TISSUE RESEARCH

Histones: At the Crossroads of Peptide and Protein Chemistry

(2014) Manuel M. Müller et al.   CHEMICAL REVIEWS

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

(2014) Lunzhi Dai et al.   Nature Chemical Biology

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Transcription through Acetylation of H3K122 on the Lateral Surface of the Histone Octamer

(2013) Philipp Tropberger et al.   CELL

Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocellular carcinomas

(2013) Nicolas Poté et al.   HEPATOLOGY

Scratching the (lateral) surface of chromatin regulation by histone modifications

(2013) Philipp Tropberger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Connecting Threads: Epigenetics and Metabolism

(2012) Sayako Katada et al.   CELL

Combinatorial complexity in chromatin structure and function: revisiting the histone code

(2012) Oliver J Rando   CURRENT OPINION IN GENETICS & DEVELOPMENT

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Fluorescence Imaging of Cellular Metabolites with RNA

(2012) Jeremy S. Paige et al.   SCIENCE

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon

(2010) Qing Zhong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association

(2010) Abdollah Allahverdi et al.   NUCLEIC ACIDS RESEARCH

Evolution of a Histone H4-K16 Acetyl-Specific DNA Aptamer

(2009) Berea A. R. Williams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Molecular Characterization of Propionyllysines in Non-histone Proteins

(2008) Zhongyi Cheng et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

(2008) Keir C Neuman et al.   NATURE METHODS