Viral manipulation of host cell necroptosis and pyroptosis

A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

(2021) Zhijun Liu et al.   IMMUNITY

Diverse viral proteases activate the NLRP1 inflammasome

(2021) Brian V Tsu et al.   eLife

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling

(2021) André L. Samson et al.   Science Signaling

The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis

(2021) Xia-lian Wu et al.   Nature Communications

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

(2021) André C. Ferreira et al.   Cell Death Discovery

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

(2021) Megan H. Orzalli et al.   IMMUNITY

Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis

(2021) Heather Koehler et al.   Cell Host & Microbe

SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage

(2021) Juan Ma et al.   EMBO JOURNAL

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

(2021) Pan Pan et al.   Nature Communications

Species-Specific Inhibition of Necroptosis by HCMV UL36

(2021) Elena Muscolino et al.   Viruses-Basel

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Viroporins and inflammasomes: A key to understand virus-induced inflammation

(2020) N.S. Farag et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells

(2020) M. Zeeshan Chaudhry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor

(2020) Alice Fletcher-Etherington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death

(2020) Megan Steain et al.   PLoS Pathogens

Necroptosis restricts influenza A virus as a stand-alone cell death mechanism

(2020) Maria Shubina et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

(2020) Kim S. Robinson et al.   SCIENCE

Cell death signalling in virus infection

(2020) Gergely Imre   CELLULAR SIGNALLING

Targeting immunogenic cell death in cancer

(2020) Asma Ahmed et al.   Molecular Oncology

Human NLRP1 is a sensor for double-stranded RNA

(2020) Stefan Bauernfried et al.   SCIENCE

Emerging Role of PYHIN Proteins as Antiviral Restriction Factors

(2020) Matteo Bosso et al.   Viruses-Basel

Poxviral Strategies to Overcome Host Cell Apoptosis

(2020) Chathura D. Suraweera et al.   Pathogens

Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins

(2020) Nirukshan Shanmugam et al.   BIOPHYSICAL CHEMISTRY

Detection of viruses by inflammasomes

(2020) Lotte Spel et al.   Current Opinion in Virology

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development

(2019) Xuhua Zhang et al.   Cell Death & Disease

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis

(2019) Nathalia M. de Vasconcelos et al.   Cold Spring Harbor Perspectives in Biology

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

(2019) Emma J. Petrie et al.   Cell Reports

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

(2019) Najoua Lalaoui et al.   NATURE

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

(2019) Panfeng Tao et al.   NATURE

Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism

(2019) Elena Muscolino et al.   Nature Microbiology

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

(2018) Miguel Mompeán et al.   CELL

Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

(2018) Yuhei Maruzuru et al.   Cell Host & Microbe

An update on the NLRP3 inflammasome and influenza: the road to redemption or perdition?

(2018) Tate Michelle D et al.   CURRENT OPINION IN IMMUNOLOGY

Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly

(2018) Takayuki Komatsu et al.   JOURNAL OF VIROLOGY

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

(2018) Xiaolan Liu et al.   Cell Death & Disease

Necroptosis in anti-viral inflammation

(2018) Himani Nailwal et al.   CELL DEATH AND DIFFERENTIATION

NLRP3 deficiency exacerbates enterovirus infection in mice

(2018) Chen Wang et al.   FASEB JOURNAL

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

(2018) Hongyan Guo et al.   Cell Death & Disease

Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies

(2018) Chi LL Pham et al.   EMBO REPORTS

Oncolytic virus-induced cell death and immunity: a match made in heaven?

(2017) Jolien De Munck et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasome antagonism by human parainfluenza virus type 3 C protein

(2017) Niraj K. Shil et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

(2017) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways

(2017) Lisa P. Daley-Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3

(2017) Heather Koehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection

(2017) Megan H. Orzalli et al.   TRENDS IN CELL BIOLOGY

Virus Infection and Death Receptor-Mediated Apoptosis

(2017) Xingchen Zhou et al.   Viruses-Basel

Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease

(2017) Hanne Van Gorp et al.   Cold Spring Harbor Perspectives in Biology

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types

(2016) Megan H. Orzalli et al.   JOURNAL OF VIROLOGY

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion

(2016) Miyu Moriyama et al.   JOURNAL OF VIROLOGY

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An evolutionary perspective on the necroptotic pathway

(2016) Yves Dondelinger et al.   TRENDS IN CELL BIOLOGY

Herpes Simplex Virus Suppresses Necroptosis in Human Cells

(2015) Hongyan Guo et al.   Cell Host & Microbe

RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice

(2015) Zhe Huang et al.   Cell Host & Microbe

Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors

(2015) Sergio M. Pontejo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manipulation of apoptosis and necroptosis signaling by herpesviruses

(2015) Hongyan Guo et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

IAPs, regulators of innate immunity and inflammation

(2015) Yann Estornes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Viral IAPs, then and now

(2015) Rollie J. Clem   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: The Trojan horse in cell autonomous antiviral host defense

(2015) Edward S. Mocarski et al.   VIROLOGY

How do viruses control mitochondria-mediated apoptosis?

(2015) Simon Neumann et al.   VIRUS RESEARCH

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

(2015) Hongbin Wang et al.   Cell Reports

Inflammasome control of viral infection

(2015) Christopher Lupfer et al.   Current Opinion in Virology

Viral Proteins That Bind Double-Stranded RNA: Countermeasures Against Host Antiviral Responses

(2014) Robert M. Krug   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

(2013) M. Gerlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1  Secretion

(2011) N. Komune et al.   JOURNAL OF VIROLOGY

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

(2011) S. M. Gregory et al.   SCIENCE

The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8

(2010) Florent Dufour et al.   APOPTOSIS

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

Cytomegalovirus M45 Cell Death Suppression Requires Receptor-interacting Protein (RIP) Homotypic Interaction Motif (RHIM)-dependent Interaction with RIP1

(2008) Jason W. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein

(2008) C. Mack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA