SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

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Global absence and targeting of protective immune states in severe COVID-19

(2021) Alexis J. Combes et al.   NATURE

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

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Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

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NLRP3 Inflammasome—A Key Player in Antiviral Responses

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Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

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Effective treatment of severe COVID-19 patients with tocilizumab

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Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

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COVID-19, SARS and MERS: are they closely related?

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Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

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The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

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Cancer, COVID-19, and Antiviral Immunity: The CAPTURE Study

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Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

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Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

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Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

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Emerging Activators and Regulators of Inflammasomes and Pyroptosis

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The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

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Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

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Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

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Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

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Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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Human Monocytes Engage an Alternative Inflammasome Pathway

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Pore-forming activity and structural autoinhibition of the gasdermin family

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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

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Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein

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Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

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Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

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