Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

N-degron and C-degron pathways of protein degradation

(2019) Alexander Varshavsky   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal degradation activates the NLRP1B inflammasome

(2019) Ashley J. Chui et al.   SCIENCE

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin

(2019) Hao Xu et al.   EMBO JOURNAL

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation

(2019) Richard T. Timms et al.   SCIENCE

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

(2019) Scott B. Drutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium

(2019) SangJoon Lee et al.   Science Immunology

Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant

(2019) Troels Herlin et al.   RHEUMATOLOGY

Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes

(2018) Jennifer Sand et al.   Cell Death & Disease

Bronchial extracellular matrix from COPD patients induces altered gene expression in repopulated primary human bronchial epithelial cells

(2018) Ulf Hedström et al.   Scientific Reports

Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation

(2018) Sarah N. Croft et al.   Scientific Reports

Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus

(2018) Valia T. Mihaylova et al.   Cell Reports

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

(2018) Franklin L. Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling

(2018) Chengkang Zhang et al.   Cell Reports

Antiviral Response in the Nasopharynx Identifies Patients With Respiratory Virus Infection

(2017) Marie L Landry et al.   JOURNAL OF INFECTIOUS DISEASES

Marker-free coselection for CRISPR-driven genome editing in human cells

(2017) Daniel Agudelo et al.   NATURE METHODS

Picornaviruses and Apoptosis: Subversion of Cell Death

(2017) Sarah N. Croft et al.   mBio

A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD ( NLRP1- associated autoinflammation with arthritis and dyskeratosis)

(2016) Sylvie Grandemange et al.   ANNALS OF THE RHEUMATIC DISEASES

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

(2016) Franklin L. Zhong et al.   CELL

Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro

(2016) Yan Yan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

(2016) Joseph Chavarría-Smith et al.   PLoS Pathogens

Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition

(2015) Bing Tian et al.   BMC GENOMICS

Multiple Self-Healing Palmoplantar Carcinoma: A Familial Predisposition to Skin Cancer with Primary Palmoplantar and Conjunctival Lesions

(2015) Ons Mamaï et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plasticity of Airway Epithelial Cell Transcriptome in Response to Flagellin

(2015) Joan G. Clark et al.   PLoS One

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

Human Rhinoviruses

(2013) Samantha E. Jacobs et al.   CLINICAL MICROBIOLOGY REVIEWS

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

The Role of Interleukin-1 and Interleukin-18 in Pro-Inflammatory and Anti-Viral Responses to Rhinovirus in Primary Bronchial Epithelial Cells

(2013) Siân C. Piper et al.   PLoS One

Rhinovirus 3C Protease Facilitates Specific Nucleoporin Cleavage and Mislocalisation of Nuclear Proteins in Infected Host Cells

(2013) Erin J. Walker et al.   PLoS One

NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1  processing via the NLRP1 inflammasome

(2013) C. B. Levandowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

(2012) Joshua N. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages

(2012) Kristina A. Hellmich et al.   PLoS One

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in Han Chinese

(2011) Jiangdong Sui et al.   ARTHRITIS AND RHEUMATISM

CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5-Like Domain

(2011) Andrea D'Osualdo et al.   PLoS One

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Susceptibility to Anthrax Lethal Toxin-Induced Rat Death Is Controlled by a Single Chromosome 10 Locus That Includes rNlrp1

(2010) Zachary L. Newman et al.   PLoS Pathogens

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway

(2008) Katherine E. Wickliffe et al.   CELLULAR MICROBIOLOGY

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

(2008) Michael H Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases

(2008) Sylvain de Breyne et al.   VIROLOGY