β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption

Role of the NLRP3 Inflammasome in Preeclampsia

(2020) Koumei Shirasuna et al.   Frontiers in Endocrinology

Overexpressed FOXO3 improves inflammatory status in mice by affecting NLRP3-mediated cell coronation in necrotizing colitis mice

(2020) Yiyu Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

The NLRP3 Inflammasome Role in the Pathogenesis of Pregnancy Induced Hypertension and Preeclampsia

(2020) Maciej W. Socha et al.   Cells

β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology

(2020) Daniel C. Shippy et al.   Journal of Neuroinflammation

Inflammasome and Caspase-1 Activity Characterization and Evaluation: An Imaging Flow Cytometer–Based Detection and Assessment of Inflammasome Specks and Caspase-1 Activation

(2019) Abhinit Nagar et al.   JOURNAL OF IMMUNOLOGY

β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects

(2019) Takaya Tajima et al.   KIDNEY INTERNATIONAL

Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice

(2019) Wanjun Fang et al.   JOURNAL OF NUTRITION

Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury

(2019) Tomoyuki Miyauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preeclamptic patient-derived circulating cell-free DNA activates the production of inflammatory cytokines via toll-like receptor 9 signalling in the human placenta

(2019) Ayae Ozeki et al.   JOURNAL OF HYPERTENSION

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

(2018) Laura J. Yockey et al.   IMMUNITY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth and adverse neonatal outcomes†

(2018) Nardhy Gomez-Lopez et al.   BIOLOGY OF REPRODUCTION

Inflammation-Induced Intra-Amniotic inflammation induces preterm birth by Activating the NLRP3 inflammasome†

(2018) Jonathan Faro et al.   BIOLOGY OF REPRODUCTION

Role of NLRP3 Inflammasomes in Atherosclerosis

(2017) Tadayoshi Karasawa et al.   Journal of Atherosclerosis and Thrombosis

Advanced glycation end products regulate interleukin-1β production in human placenta

(2017) Kotomi SENO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Inflammation in Complicated Pregnancy and Its Outcome

(2016) Ram Kalagiri et al.   AMERICAN JOURNAL OF PERINATOLOGY

β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation

(2016) Ha Ram Bae et al.   Oncotarget

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy

(2015) Koumei Shirasuna et al.   ENDOCRINOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

NLRP3 Inflammasome as a Novel Player in Myocardial Infarction

(2014) Masafumi Takahashi   International Heart Journal

A leading role for the immune system in the pathophysiology of preeclampsia

(2013) Estibalitz Laresgoiti-Servitje   JOURNAL OF LEUKOCYTE BIOLOGY

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

(2013) Petra C Arck et al.   NATURE MEDICINE

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology

(2011) Shigeru Saito et al.   Expert Review of Clinical Immunology

Intrauterine infection and preterm labor

(2011) Varkha Agrawal et al.   Seminars in Fetal & Neonatal Medicine

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

The Isolation and Characterization of a Novel Telomerase Immortalized First Trimester Trophoblast Cell Line, Swan 71

(2009) S.L. Straszewski-Chavez et al.   PLACENTA