Review
Medicine, General & Internal
Jia-Lu Shi, Zi-Meng Zheng, Min Chen, Hui-Hui Shen, Ming-Qing Li, Jun Shao
Summary: Interleukin-17 (IL-17) is a proinflammatory cytokine derived from Th17 cells, which plays a pivotal role in inflammatory and autoimmune diseases. It is also linked to endometriosis, where IL-17 expression is up-regulated. IL-17 is involved in the regulation of immune microenvironment and the growth and invasion of ectopic lesions, suggesting its therapeutic value in endometriosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Obstetrics & Gynecology
Kjerstine Breintoft, Linn Hakonsen Arendt, Niels Uldbjerg, Maria Tolboll Glavind, Axel Forman, Tine Brink Henriksen
Summary: The study found that women with endometriosis have a higher risk of preterm and very preterm birth, with different pathways identified. Women with endometriosis are more likely to have medically indicated preterm births before 37 weeks gestation, and spontaneous preterm births before 32 weeks gestation, compared to women without endometriosis.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Medicine, General & Internal
Louis Marcellin, Francois Goffinet, Elie Azria, Anne Thomin, Charles Garabedian, Jeanne Sibiude, Eric Verspyck, Martin Koskas, Pietro Santulli, Jessica Rousseau, Pierre-Yves Ancel, Charles Chapron
Summary: This cohort study found no association between endometriosis and preterm birth, and the disease phenotype did not appear to alter the result.
Article
Medicine, General & Internal
Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Derek Miller, Valeria Garcia-Flores, Marcia Arenas-Hernandez, Andrew D. Winters, Bruce A. Berkowitz, Robert H. Podolsky, Yimin Shen, Tomi Kanninen, Bogdan Panaitescu, Catherine R. Glazier, Roger Pique-Regi, Kevin R. Theis, Nardhy Gomez-Lopez
Summary: This study investigates the role of IL-6 and IL-1 alpha in sterile intra-amniotic inflammation (SIAI) and their impact on preterm birth and neonatal outcomes. The researchers found that IL-6 plays a critical role in the inflammatory response and that IL-1 alpha injection leads to preterm birth and neonatal mortality. Prenatal treatment with an IL-6R blockade shows promising results in preventing preterm birth and improving neonatal outcomes.
Article
Chemistry, Analytical
Somayeh Mohammadi Far, Matin Beiramvand, Mohammad Shahbakhti, Piotr Augustyniak
Summary: Timely prediction of preterm labor is crucial for neonate survival, mother's mental health, and reducing financial burdens on the family. This study proposes a reliable method using electrohysterogram (EHG) signals to predict preterm labor based on different pregnancy weeks. EHG signals from 300 subjects were split into two groups and analyzed using empirical mode decomposition (EMD), feature extraction, oversampling, and feature selection techniques. The AdaBoost classifier achieved high accuracy and performance for both groups. The results indicate the feasibility of the proposed method for preterm labor prediction.
Article
Immunology
Dongni Huang, Yuxin Ran, Zheng Liu, Jie He, Nanlin Yin, Hongbo Qi
Summary: Preterm labor is a multifactorial syndrome that involves the abnormal expression of IL-27 and its receptors. This study demonstrated that the IL-27/IFN-γ/ERK axis mediates the inflammatory effect in preterm labor, and WSX-1 knockdown can delay birth. The findings suggest a potential therapeutic target in inhibiting the pro-inflammatory effect in preterm labor.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Obstetrics & Gynecology
Clara Q. Wu, Kelly Nichols, Matthew Carwana, Nicholas Cormier, Christina Maratta
Summary: This study conducted a systematic review and meta-analysis to evaluate the impact of recurrent pregnancy loss (RPL) on the risk of preterm birth (PTB) in subsequent pregnancies. The results showed that women with a history of RPL had significantly higher odds of delivering preterm infants in subsequent pregnancies, and the risk of PTB increased with the number of pregnancy losses.
FERTILITY AND STERILITY
(2022)
Article
Biochemistry & Molecular Biology
Mohammed Elsherbini, Kaori Koga, Eiko Maki, Keiichi Kumasawa, Erina Satake, Ayumi Taguchi, Tomoko Makabe, Arisa Takeuchi, Gentaro Izumi, Masashi Takamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Yutaka Osuga
Summary: The study aimed to establish a new mouse model of endometriosis and evaluate the impact of chronic exposure to endometriosis on perinatal outcome. The results indicate that chronic exposure to endometriosis affects perinatal outcomes, leading to increased resorptions and decreased body weight.
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Manuel S. Vidal, Ryan C. V. Lintao, Mary Elise L. Severino, Ourlad Alzeus G. Tantengco, Ramkumar Menon
Summary: Survivors of preterm birth face various disabilities, and addressing the rates of low birth weight, neonatal and maternal morbidities and mortalities is crucial. Research has provided theories on risk factors and clinical manifestations, but there is a lack of biomarkers for early diagnosis. To overcome current limitations, an integrated approach studying the network interaction between different tissues and organs is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Brahm Seymour Coler, Oksana Shynlova, Adam Boros-Rausch, Stephen Lye, Stephen McCartney, Kelycia B. Leimert, Wendy Xu, Sylvain Chemtob, David Olson, Miranda Li, Emily Huebner, Anna Curtin, Alisa Kachikis, Leah Savitsky, Jonathan W. Paul, Roger Smith, Kristina M. Adams Waldorf
Summary: Preterm birth remains a significant cause of infant morbidity and mortality, with limited therapeutic options despite 50 years of research. The global need for better tocolytic agents is particularly urgent, with newer therapeutics targeting inflammatory checkpoints for more effective tocolysis. However, regulatory hurdles and a small market for new PTB therapeutics have hindered pharmaceutical interest in this area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Michelle Coleman, Blair Armistead, Austyn Orvis, Phoenicia Quach, Alyssa Brokaw, Claire Gendrin, Kavita Sharma, Jason Ogle, Sean Merillat, Matthew Dacanay, Tsung-Yen Wu, Jeff Munson, Audrey Baldessari, Jay Vornhagen, Anna Furuta, Shayla Nguyen, Kristina M. Adams Waldorf, Lakshmi Rajagopal
Summary: Invasive bacterial infections during pregnancy, such as Group B streptococci (GBS), can lead to preterm birth, stillbirth, and fetal injury. Using a nonhuman primate model, researchers found that GBS expressing hyaluronidase can cause microbial invasion into the amniotic cavity and preterm labor, shedding light on virulence factors and potential therapeutic strategies. Understanding how bacteria evade host defenses during pregnancy is crucial for developing preventive therapies against adverse outcomes.
Review
Cell Biology
Maciej W. Socha, Wojciech Flis, Milosz Pietrus, Mateusz Wartega, Martyna Stankiewicz
Summary: Cervical ripening is a crucial process in late pregnancy, primarily caused by enzymatic breakdown and inflammatory response. The cellular pathways responsible for regulating this process are still poorly understood, but gaining a greater understanding can help address dysfunctional labor issues.
Article
Obstetrics & Gynecology
David B. Nelson, Donald D. McIntire, Kenneth J. Leveno
Summary: This article discusses the results of a clinical trial in the US on preterm birth prevention, which failed to demonstrate the effectiveness of a drug in preventing recurrent preterm birth, leading to reflections on accelerated approval and pharmaceutical regulatory processes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Microbiology
Milan Terzic, Gulzhanat Aimagambetova, Sanja Terzic, Milena Radunovic, Gauri Bapayeva, Antonio Simone Lagana
Summary: Preterm labor refers to birth before 37 weeks of gestation, occurring in 5-20% of pregnancies. Influenced by maternal, fetal, and environmental factors, infectious pathogens may account for 25-40% of preterm birth. The association between maternal periodontal disease, pathogenic oral bacteria in the placenta, and preterm delivery is still controversial in spite of extensive research.
