Inflammasome and Caspase-1 Activity Characterization and Evaluation: An Imaging Flow Cytometer–Based Detection and Assessment of Inflammasome Specks and Caspase-1 Activation

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC

(2018) Yann Gambin et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamics of in vivo ASC speck formation

(2017) Paola Kuri et al.   JOURNAL OF CELL BIOLOGY

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division

(2016) Robert Stein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

(2016) Leanne Mortimer et al.   NATURE IMMUNOLOGY

ASC filament formation serves as a signal amplification mechanism for inflammasomes

(2016) Mathias S. Dick et al.   Nature Communications

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Inflammasomes and human autoimmunity: A comprehensive review

(2015) Chin-An Yang et al.   JOURNAL OF AUTOIMMUNITY

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

(2015) Magdalena Matusiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Human Procaspase-1 Variants with Decreased Enzymatic Activity Are Associated with Febrile Episodes and May Contribute to Inflammation via RIP2 and NF- B Signaling

(2014) M. C. Heymann et al.   JOURNAL OF IMMUNOLOGY

A Novel Flow Cytometric Method To Assess Inflammasome Formation

(2014) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Dynamics Aspects of ASC Speck Assembly

(2014) Ali Can Sahillioglu et al.   STRUCTURE

Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response

(2014) Ting Liu et al.   Cell Reports

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

(2013) Anna Sokolovska et al.   NATURE IMMUNOLOGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Francisella tularensisReveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation

(2011) Maninjay K. Atianand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

(2009) Laura E Edgington et al.   NATURE MEDICINE