The molecular basis of T cell acute lymphoblastic leukemia

TLX Homeodomain Oncogenes Mediate T Cell Maturation Arrest in T-ALL via Interaction with ETS1 and Suppression of TCRα Gene Expression

(2012) Saïda Dadi et al.   CANCER CELL

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

(2012) C. Simon et al.   GENES & DEVELOPMENT

Preclinical Analysis of the  -Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

(2012) J. B. Samon et al.   MOLECULAR CANCER THERAPEUTICS

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

(2012) Giusy Della Gatta et al.   NATURE MEDICINE

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

(2011) A. Gutierrez et al.   BLOOD

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

(2011) Irene Homminga et al.   CANCER CELL

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

(2011) V. Grossmann et al.   HAEMATOLOGICA

ETV6mutations in early immature human T cell leukemias

(2011) Pieter Van Vlierberghe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gain-of-function mutations ininterleukin-7 receptor-α(IL7R) in childhood acute lymphoblastic leukemias

(2011) Chen Shochat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

(2011) Priscila P Zenatti et al.   NATURE GENETICS

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

(2010) A. Gutierrez et al.   BLOOD

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia

(2010) Maddalena Paganin et al.   BLOOD REVIEWS

Absence of Biallelic TCRγ Deletion Predicts Early Treatment Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia

(2010) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL ONCOLOGY

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols

(2010) L Zuurbier et al.   LEUKEMIA

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

(2010) E Clappier et al.   LEUKEMIA

The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function

(2010) C Kox et al.   LEUKEMIA

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

PHF6 mutations in T-cell acute lymphoblastic leukemia

(2010) Pieter Van Vlierberghe et al.   NATURE GENETICS

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

The TLX1 oncogene drives aneuploidy in T cell transformation

(2010) Kim De Keersmaecker et al.   NATURE MEDICINE

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-  and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

(2009) M. Remke et al.   BLOOD

WT1 mutations in T-ALL

(2009) V. Tosello et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

JAK1 mutations are not frequent events in adult T-ALL: a GRAALL study

(2009) Vahid Asnafi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia

(2009) D. Krieger et al.   HAEMATOLOGICA

Prognostic Implications ofNOTCH1andFBXW7Mutations in Adults With T-Cell Acute Lymphoblastic Leukemia Treated on the MRC UKALLXII/ECOG E2993 Protocol

(2009) Marc R. Mansour et al.   JOURNAL OF CLINICAL ONCOLOGY

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

(2009) Elaine Coustan-Smith et al.   LANCET ONCOLOGY

Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies

(2009) A Renneville et al.   LEUKEMIA

NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia

(2009) P J Real et al.   LEUKEMIA

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes

(2009) A. A. Margolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of NOTCH1 signaling in T-ALL

(2009) A. A. Ferrando   Hematology-American Society of Hematology Education Program

Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis

(2008) B. V. Balgobind et al.   BLOOD

NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study

(2008) V. Asnafi et al.   BLOOD

K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to  -secretase inhibitors

(2008) T. Kindler et al.   BLOOD

The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia

(2008) P. Van Vlierberghe et al.   BLOOD

NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL

(2008) M. L. Sulis et al.   BLOOD

Prognostic Factors for Leukemic Induction Failure in Children With Acute Lymphoblastic Leukemia and Outcome After Salvage Therapy: The FRALLE 93 Study

(2008) Caroline Oudot et al.   JOURNAL OF CLINICAL ONCOLOGY

Somatically acquiredJAK1mutations in adult acute lymphoblastic leukemia

(2008) Elisabetta Flex et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group

(2008) U Baak et al.   LEUKEMIA

Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases

(2008) K De Keersmaecker et al.   LEUKEMIA

Activity of tyrosine kinase inhibitors against human NUP214-ABL1-positive T cell malignancies

(2008) A Quintás-Cardama et al.   LEUKEMIA

Kinase Activation and Transformation by NUP214-ABL1 Is Dependent on the Context of the Nuclear Pore

(2008) Kim De Keersmaecker et al.   MOLECULAR CELL

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE