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Medicine, Research & Experimental
Qingzhu Jia, Diyuan Qin, Feng He, Qichao Xie, Zhitao Ying, Yajing Zhang, Yuqin Song, Jia-Nan Cheng, Xuejiao Zuo, Luxiang Xu, Hongliang Fang, Chunyan Hu, Lina Peng, Tao Jin, Zixiao Shi, Peter B. Alexander, Yongsheng Wang, Yarong Liu, Weidong Han, Jun Zhu, Pin Wang, Qi-Jing Li, Bo Zhu
Summary: This study identified the baseline high eosinophil count as a potential biomarker for predicting the clinical efficacy of CAR-T cell therapy in B-NHL patients. A preclinical model demonstrated that depletion of eosinophils could impair the intratumoral infiltration and antitumor efficacy of CAR-T cells.
Review
Biochemistry & Molecular Biology
Cheong-Whan Chae, Gun Choi, You Ji Kim, Mingug Cho, Yoo-Wook Kwon, Hyo-Soo Kim
Summary: KAI1 acts as a functional surface marker of LT-HSCs that regulates dormancy through interaction with DARC-expressing macrophages in the stem cell niche.
Article
Medicine, Research & Experimental
Wei Zhang, Qian Zhang, Chao Zhu, Zhiyuan Shi, Chen Shao, Yujie Chen, Nan Wang, Yanxia Jiang, Qing Liang, Kejia Wang
Summary: This study revealed diminished T-cell infiltration and increased T-cell receptor immune repertoire diversity in clear cell renal cell cancer (ccRCC). Furthermore, Vimentin expression in ccRCC tissue was positively correlated with the presence of positive T-cell markers. The immune repertoire sequencing results showed increased diversity in the T-cell receptor repertoire in ccRCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ayano Kabashima, Yuki Matsuo, Saki Ito, Yoshimitsu Akiyama, Takeshi Ishii, Shu Shimada, Atsushi Masamune, Minoru Tanabe, Shinji Tanaka
Summary: This study investigates the impact of cGAS-STING expression and the presence of cancer-associated fibroblasts (CAFs) on immune cell infiltration in pancreatic ductal adenocarcinoma (PDAC). The results show that PDAC cases with co-expression of cGAS and STING have favorable survival and exhibit cytotoxic CD8 + T cell infiltrations. However, the presence of CAFs impedes immune cell infiltration.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Nuo Xu, Douglas C. Palmer, Alexander C. Robeson, Peishun Shou, Hemamalini Bommiasamy, Sonia J. Laurie, Caryn Willis, Gianpietro Dotti, Benjamin G. Vincent, Nicholas P. Restifo, Jonathan S. Serody
Summary: The study demonstrates that enhancing CAR T cell therapy targeting solid tumors with STING agonists, specifically DMXAA, can greatly improve tumor control by promoting CAR T cell trafficking and persistence in the tumor microenvironment. The single-cell RNA sequencing results show that DMXAA generates a chemokine milieu that facilitates CART cell recruitment and modulates the immunosuppressive TME.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Arianne C. Richard, Claire Y. Ma, John C. Marioni, Gillian M. Griffiths
Summary: This study investigates the impact of transcriptomic changes on the killing ability of effector cytotoxic T lymphocytes (CTLs). The results show that while transcription is required for the expression of cytokines/chemokines and transcriptional machinery, it is relatively robust to transcription blockade for cytotoxic protein expression and cytolytic activity. Additionally, the study reveals a cell-intrinsic transcriptional requirement for infiltration.
Article
Biology
Jinnan Xiang, Jigang Guo, Shaoyang Zhang, Hongguang Wu, Ye-Guang Chen, Junping Wang, Baojie Li, Huijuan Liu
Summary: This study found that the Twist2 stromal lineage cells play a crucial role in the growth and maintenance of intestinal stem cells (ISCs) and their ability to regenerate villi. Additionally, Acta2(+) cells also contribute to ISC regeneration. These findings suggest that different cellular niches are required for ISC-mediated villus homeostasis and regeneration.
Article
Chemistry, Physical
Guixiang Xu, Kai Liu, Xiangwu Chen, Yang Lin, Cancan Yu, Xinxin Nie, Wenxiu He, Nathan Karin, Yuxia Luan
Summary: An injectable hydrogel was designed to reinforce cancer immunotherapy by regulating CXCL10 degradation to amplify tumor T cell infiltration and inactivating PD-L1 to eliminate the PD-L1-governed immune evasion.
NANOSCALE HORIZONS
(2023)
Article
Nanoscience & Nanotechnology
Xiao Huang, Jasper Z. Williams, Ryan Chang, Zhongbo Li, Cassandra E. Burnett, Rogelio Hernandez-Lopez, Initha Setiady, Eric Gai, David M. Patterson, Wei Yu, Kole T. Roybal, Wendell A. Lim, Tejal A. Desai
Summary: The study developed biocompatible immune cell-engaging particles (ICEp) for efficient and tunable protein loading, aiming to improve the safety of immunotherapy. Injection of micrometre-sized ICEp intratumorally activates CAR T cells, leading to local tumor clearance while protecting uninjected tumors. Control of immune cell activation can enhance the efficiency of cell-based therapies and reduce associated risks.
NATURE NANOTECHNOLOGY
(2021)
Article
Immunology
Silvia Pineda, Evangelina Lopez de Maturana, Katharine Yu, Akshay Ravoor, Ines Wood, Nuria Malats, Marina Sirota
Summary: The study found that PDAC tumor tissue had richer and more diverse IG and TCR infiltration compared to normal pancreatic tissue. Specific IG clonotypes could help differentiate samples with better prognosis, while a larger TCR infiltration was associated with patients with a history of diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yuan Tian, Yumei Wei, Hongmei Liu, Heli Shang, Yuedong Xu, Tong Wu, Wei Liu, Alan Huang, Qi Dang, Yuping Sun
Summary: In this study, the significance of CD8(+) T cell-related markers in patients with KIRC was comprehensively analyzed. A 6-gene risk scoring model specific to TIL-CD8T was constructed based on multi-platform analyses. Different prognosis of patients with the same or similar immune checkpoint gene levels could be distinguished by TIL-CD8 sig score.
Review
Biochemistry & Molecular Biology
Rick Wilbrink, Anneke Spoorenberg, Gwenny M. P. J. Verstappen, Frans G. M. Kroese
Summary: Research suggests that genetics, immune reactions, and the joint-gut axis play major roles in the etiology of ankylosing spondylitis (AS). While B cells have been traditionally understudied in AS pathogenesis, increasing evidence points to their involvement, with disturbances in B cell populations and the formation of antibodies seen in AS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zhigang Li, Xuemei Fu, Weiru Wu, Zhilong Liu, Zhe Chen, Chengfang Zhou, Yuanyuan Liu, Mei Kuang, Fangfang Sun, Feifei Xiao, Yongxiu Huang, Xiaojun Zhang, Shijun Fan, Xingqin Huang, Guangling Zheng, Jieping Chen, Yu Hou
Summary: Zfp521 is a critical regulator of quiescence and self-renewal of HSC in adult hematopoiesis, mediating its effects partly through controlling Rela expression, especially under regenerative stress conditions.
Article
Biochemistry & Molecular Biology
Junwei Liu, Jie Li, Zhan Tuo, Weidong Hu, Jun Liu
Summary: Immune checkpoint blockades have shown breakthroughs in certain types of cancer, but the response rate is low. The underlying mechanisms and efficient biomarkers to predict immunotherapy resistances are still unclear. This study found that BATF2 inhibits the expression of programmed death-ligand 1 in cancer cells by suppressing the PI3K-AKT pathway. BATF2 promotes antitumor immune response and can serve as an efficient biomarker to predict diagnosis, prognosis, and immunotherapy efficacy in patients with non-small cell lung cancer.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Kurt Berckmueller, Justin Thomas, Eman A. Taha, Seunga Choo, Ravishankar Madhu, Greta Kanestrom, Peter B. Rupert, Roland Strong, Hans-Peter Kiem, Stefan Radtke
Summary: Novel HSC-targeted viral vectors have been developed that can specifically transduce CD90-expressing HSCs, and are expected to have significant potential in ex vivo gene therapy.
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Endocrinology & Metabolism
Jian Yu, Jingjing Cao, Hanjun Li, Pei Liu, Shuqin Xu, Rujiang Zhou, Zhengju Yao, Xizhi Guo
Article
Multidisciplinary Sciences
You Wang, Chunying Li, Md Rezaul Islam Khan, Yushu Wang, Yunfeng Ruan, Bin Zhao, Bo Zhang, Xiaopan Ma, Kaisi Zhang, Xiwen Zhao, Guanhao Ye, Xizhi Guo, Guoyin Feng, Lin He, Gang Ma
SCIENTIFIC REPORTS
(2016)
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Cell & Tissue Engineering
Qian Cong, Hao Jia, Soma Biswas, Ping Li, Shoutao Qiu, Qi Deng, Xizhi Guo, Gang Ma, Jenny Fang Ling Chau, Yibin Wang, Zhen-Lin Zhang, Xinquan Jiang, Huijuan Liu, Baojie Li
Article
Medicine, Research & Experimental
Hanjun Li, Pei Liu, Shuqin Xu, Yinghua Li, Joseph D. Dekker, Baojie Li, Ying Fan, Zhenlin Zhang, Yang Hong, Gong Yang, Tingting Tang, Yongxin Ren, Haley O. Tucker, Zhengju Yao, Xizhi Guo
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Multidisciplinary Sciences
Shuqin Xu, Pei Liu, Yuanxing Chen, Yi Chen, Wei Zhang, Haixia Zhao, Yiwei Cao, Fuhua Wang, Nana Jiang, Shifeng Lin, Baojie Li, Zhenlin Zhang, Zhanying Wei, Ying Fan, Yunyun Jin, Lin He, Rujiang Zhou, Joseph D. Dekker, Haley O. Tucker, Simon E. Fisher, Zhengju Yao, Quansheng Liu, Xuechun Xia, Xizhi Guo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cardiac & Cardiovascular Systems
Shasha Zhang, Zongpei Song, Lin An, Xiaoyun Liu, Xiao-Wen Hu, Amber Naz, Rujiang Zhou, Xizhi Guo, Lin He, Hongxin Zhu
CARDIOVASCULAR RESEARCH
(2019)
Article
Multidisciplinary Sciences
Lingling Zhang, Yen-Chiao Wang, Yuka Okada, Suohui Zhang, Matthew Anderson, Chia-Yang Liu, Yujin Zhang
SCIENTIFIC REPORTS
(2019)
Article
Medicine, Research & Experimental
Yuka Okada, Yujin Zhang, Lingling Zhang, Lung-Kun Yeh, Yen-Chiao Wang, Shizuya Saika, Chia-Yang Liu
LABORATORY INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Pei Liu, Sixia Huang, Shifeng Ling, Shuqin Xu, Fuhua Wang, Wei Zhang, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker, Jiqiu Wang, Xizhi Guo
NATURE COMMUNICATIONS
(2019)
Article
Ophthalmology
Meng Shi, Lingling Zhang, Eun-Ah Ye, Alice Wang, Guangyu Li, Lu Chen
Article
Cell Biology
Jingqiang Wang, Wenqian Song, Ruikai Yang, Chao Li, Ting Wu, Xiao Bing Dong, Bin Zhou, Xizhi Guo, Jianfeng Chen, Zhiyong Liu, Qing Cissy Yu, Wen Li, Junfen Fu, Yi Arial Zeng
Summary: This study reveals a crucial signaling axis in which fibroblasts relay Wnt signals from endothelial cells to organize epithelial patterning. It also demonstrates the importance of different niche components in coordinating epithelial organogenesis and tissue homeostasis.
Article
Medicine, Research & Experimental
Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E. Thibeault, Levi L. Blazer, Jarrett J. Adams, Lingling Zhang, Heidi Roehrich, Ha-Neul Jo, Somasekar Seshagiri, Sachdev S. Sidhu, Harald J. Junge, Stephane Angers
Summary: The study developed a novel tetravalent antibody F4L5.13, which can promote the expression of junction proteins on the surface of retinal endothelial cells and restore the function of the blood-retina-barrier in retinal development. Additionally, F4L5.13 can treat oxygen-induced retinopathy models characterized by abnormal neovascularization, demonstrating a new therapeutic strategy for diseases with abnormal angiogenesis and barrier dysfunction.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Yixin Tao, Qingchun Yang, Lei Wang, Jie Zhang, Xuming Zhu, Qianqian Sun, Yunbin Han, Qian Luo, Yushu Wang, Xizhi Guo, Ji Wu, Baojie Li, Xiao Yang, Lin He, Gang Ma
JOURNAL OF MOLECULAR CELL BIOLOGY
(2019)
Article
Ophthalmology
Yujin Zhang, Winston W. -Y. Kao, Yasuhito Hayashi, Lingling Zhang, Mindy Call, Fei Dong, Yong Yuan, Jianhua Zhang, Yen-Chiao Wang, Okada Yuka, Atsushi Shiraishi, Chia-Yang Liu
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Ophthalmology
Lingling Zhang, Yong Yuan, Lung-Kun Yeh, Fei Dong, Jianhua Zhang, Yuka Okada, Winston W. Y. Kao, Chia-Yang Liu, Yujin Zhang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
