Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Fluorinated Candidates as PI3K Inhibitors: Targeting Fluorophilic Binding Sites

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

(2021) Seyedeh Roya Alizadeh et al.   MEDICINAL CHEMISTRY RESEARCH

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment

(2021) Adel A. Marzouk et al.   BIOORGANIC CHEMISTRY

PI3K inhibitors are finally coming of age

(2021) Bart Vanhaesebroeck et al.   NATURE REVIEWS DRUG DISCOVERY

Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors

(2020) Ru-Yi Jin et al.   BIOORGANIC CHEMISTRY

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

(2020) Fei Xu et al.   Cell and Bioscience

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Comparative biological study between quinazolinyl–triazinyl semicarbazide and thiosemicarbazide hybrid derivatives

(2020) Janki J. Patel et al.   MOLECULAR DIVERSITY

Palladium-Catalyzed Cyanation under Mild Conditions: A Case Study to Discover Appropriate Substrates among Halides and Pseudohalides

(2020) K. Sunil et al.   SYNLETT

What Does the “AKT” Stand for in the Name “AKT Kinase”? Some Historical Comments

(2020) Jiuyong Xie et al.   Frontiers in Oncology

Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking

(2020) Amira A. Helwa et al.   BIOORGANIC CHEMISTRY

Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review

(2020) Sara Janowska et al.   MOLECULES

Thiadiazole derivatives as anticancer agents

(2020) Monika Szeliga   Pharmacological Reports

2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents

(2020) Yichao Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anticancer evaluation of novel 1,3-benzodioxoles and 1,4-benzodioxines

(2019) Rasha Mohamed Hassan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer

(2019) Fatma M. Elmenier et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

(2018) Temístocles Italo de Santana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and isomerization of acridine substituted 1,3-thiazolidin-4-ones and 4-oxo-1,3-thiazolidin-5-ylidene acetates. An experimental and computational study

(2018) Michal Bečka et al.   JOURNAL OF MOLECULAR STRUCTURE

The Idiopathic Intracranial Hypertension Treatment Trial: A Review of the Outcomes

(2017) Stacy V. Smith et al.   HEADACHE

Anticancer potential of new steroidal thiazolidin-4-one derivatives. Mechanisms of cytotoxic action and effects on angiogenesis in vitro

(2017) Marijana B. Živković et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Synthesis of 2-amino-substituted-1,3,4-thiadiazoles via 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated intramolecular C–S bond formation in thiosemicarbazones

(2016) Sarangthem Joychandra Singh et al.   TETRAHEDRON LETTERS

Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation

(2014) Pengfei Niu et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Novel Highly Functionalized 4-Thiazolidinone Derivatives from 4-Phenyl-3-thiosemicarbazones

(2014) Abdelmadjid Benmohammed et al.   MOLECULES

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

(2013) Pascal Furet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design

(2013) Yanlong Zhao et al.   ACS Medicinal Chemistry Letters

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors usingin vitromutagenesis of non-conserved amino acids and kinetic analysis

(2012) Zhaohua Zheng et al.   BIOCHEMICAL JOURNAL

One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles

(2011) Dalip Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual Inhibitors of PI3K/mTOR or mTOR-Selective Inhibitors: Which Way Shall We Go?

(2011) D. A. Sabbah et al.   CURRENT MEDICINAL CHEMISTRY

Design and synthesis of novel stiripentol analogues as potential anticonvulsants

(2011) Mohamed N. Aboul-Enein et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A General Method for Palladium-Catalyzed Reactions of Primary Sulfonamides with Aryl Nonaflates

(2011) Shashank Shekhar et al.   JOURNAL OF ORGANIC CHEMISTRY

Isoform-Selective Inhibition of Phosphoinositide 3-Kinase: Identification of a New Region of Nonconserved Amino Acids Critical for p110  Inhibition

(2011) Z. Zheng et al.   MOLECULAR PHARMACOLOGY

A convenient and efficient synthesis of heteroaromatic hydrazone derivatives via cyclization of thiosemicarbazone with ω-bromoacetophenone

(2010) Weiwei Liu et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments

(2010) Anna Vulpetti et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Effect of Fluorination on the Pharmacological Profile of 11β Isomers of Fulvestrant in Breast Carcinoma Cells

(2009) Vangelis Agouridas et al.   JOURNAL OF MEDICINAL CHEMISTRY

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH