标题
2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents
作者
关键词
2-Aminothiazole, Drug design, Anti-Cancer, Structure-activity relationships
出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 210, Issue -, Pages 112953
出版商
Elsevier BV
发表日期
2020-10-30
DOI
10.1016/j.ejmech.2020.112953
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Recent advances in isatin hybrids as potential anticancer agents
- (2020) Zhen Ding et al. ARCHIV DER PHARMAZIE
- Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders
- (2020) Meng Cheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors
- (2020) Ru-Yi Jin et al. BIOORGANIC CHEMISTRY
- Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity
- (2020) Thoraya A. Farghaly et al. BIOORGANIC CHEMISTRY
- Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance
- (2020) Stella Cascioferro et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
- (2020) Dongwei Kang et al. JOURNAL OF MEDICINAL CHEMISTRY
- A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy
- (2020) Adileh Ayati et al. BIOORGANIC CHEMISTRY
- New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria
- (2020) Pietro Picconi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel Hybrid of Vorinostat and Riluzole as a Potent Antitumor Agent
- (2020) Qifu Xu et al. Frontiers in Cell and Developmental Biology
- The importance of indole and azaindole scaffold in the development of antitumor agents
- (2020) Yu Han et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains
- (2019) Fatima Naaz et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis and Evaluation of Novel Heteroaryldihydropyrimidines Derivatives as Non-nucleoside Hepatitis B Virus Inhibitors by Exploring the Solvent-exposed Region
- (2019) Ji Yu et al. Chemical Biology & Drug Design
- Tetrazole hybrids with potential anticancer activity
- (2019) Jingyu Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- An overview on the synthetic and medicinal perspectives of indenopyrazoles
- (2019) Irfan Khan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Searching New Structural Scaffolds for BRAF Inhibitors. An Integrative Study using theoretical and experimental techniques
- (2019) Ludmila E. Campos et al. BIOORGANIC CHEMISTRY
- Insights into new mechanisms and models of cancer stem cell multidrug resistance
- (2019) Y. Garcia-Mayea et al. SEMINARS IN CANCER BIOLOGY
- Anti-inflammatory Effect of Pomelo Peel and Its Bioactive Coumarins
- (2019) Yun-Li Zhao et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites
- (2019) Zhiran Ju et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Coumarin-containing hybrids and their anticancer activities
- (2019) Longfei Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer
- (2019) Franziska E. Marquard et al. BIOCHEMICAL PHARMACOLOGY
- Recent advances in steroid amino acid conjugates: Old scaffolds with new dimensions
- (2019) Poonam Singla et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer
- (2019) Fatma M. Elmenier et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid
- (2019) Lucie Borková et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Indole: A privileged scaffold for the design of anti-cancer agents
- (2019) Yichao Wan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer
- (2019) Lei Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site
- (2018) Ling Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Efficient Synthesis of New Benzofuran-based Thiazoles and Investigation of their Cytotoxic Activity Against Human Breast Carcinoma Cell Lines
- (2018) Sobhi M. Gomha et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
- (2018) Mehlika Altıntop et al. MOLECULES
- Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
- (2018) Matthew Dankner et al. ONCOGENE
- Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents
- (2018) Yalan Guo et al. ACS Medicinal Chemistry Letters
- Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives
- (2018) Anis Ahamed et al. SAUDI JOURNAL OF BIOLOGICAL SCIENCES
- Research advances on anticancer activities of matrine and its derivatives: An updated overview
- (2018) Haroon ur Rashid et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antitumoral activity of quinoxaline derivatives: A systematic review
- (2018) M. Montana et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazole derivatives
- (2017) Thiago David dos Santos Silva et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity
- (2017) Maolin Sun et al. PLoS One
- Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide–hydrazone and carboxamide moiety
- (2016) Haifeng He et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Riluzole mediates anti-tumor properties in breast cancer cells independent of metabotropic glutamate receptor-1
- (2016) Cecilia L. Speyer et al. BREAST CANCER RESEARCH AND TREATMENT
- Pyrrole: An emerging scaffold for construction of valuable therapeutic agents
- (2016) Somnath S. Gholap EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Recent developments of 2-aminothiazoles in medicinal chemistry
- (2016) Debasis Das et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Indole Based Weapons to Fight Antibiotic Resistance: A Structure–Activity Relationship Study
- (2016) Susan Lepri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Thiazole-based nitrogen mustards: Design, synthesis, spectroscopic studies, DFT calculation, molecular docking, and antiproliferative activity against selected human cancer cell lines
- (2016) Krzysztof Z. Łączkowski et al. JOURNAL OF MOLECULAR STRUCTURE
- Synthesis and antiproliferative activity of D-ring substituted steroidal benzamidothiazoles
- (2016) Ning-Juan Fan et al. STEROIDS
- Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAFV600E inhibitors
- (2015) Meng-Yue Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity
- (2015) Fang Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment
- (2015) Arvind S. Negi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors
- (2015) Markian M. Stec et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors
- (2015) Robin A. Fairhurst et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of a novel tricyclic 4H-thiazolo[5′,4′:4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity
- (2015) Marc Gerspacher et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification and optimisation of a 4′,5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors
- (2015) Robin A. Fairhurst et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells
- (2015) Jessica L. F. Teh et al. BREAST CANCER RESEARCH AND TREATMENT
- Hitting the brakes: targeting microtubule motors in cancer
- (2015) Gayathri Chandrasekaran et al. BRITISH JOURNAL OF CANCER
- Anti-Cancer Effect of Metabotropic Glutamate Receptor 1 Inhibition in Human Glioma U87 Cells: Involvement of PI3K/Akt/mTOR Pathway
- (2015) Chi Zhang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Utility of 3-Acetyl-6-bromo-2H-chromen-2-one for the Synthesis of New Heterocycles as Potential Antiproliferative Agents
- (2015) Sobhi Gomha et al. MOLECULES
- Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole Moiety
- (2015) Sobhi Gomha et al. MOLECULES
- Control of microtubule organization and dynamics: two ends in the limelight
- (2015) Anna Akhmanova et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression
- (2015) Stephen A. Rosenberg et al. Translational Oncology
- Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme
- (2014) Jack U. Flanagan et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors
- (2014) Dominik Vogt et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors
- (2014) Daniela Secci et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and structure–activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3- d ]pyrimidine derivatives
- (2014) Fangbin Han et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression
- (2014) Y. Wen et al. CANCER RESEARCH
- Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies
- (2014) Simone Carradori et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: Synthesis and in vitro biological evaluation as antimicrobial and anticancer agents
- (2014) Sherif A.F. Rostom et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Importance of Sphingosine Kinase (SphK) as a Target in Developing Cancer Therapeutics and Recent Developments in the Synthesis of Novel SphK Inhibitors
- (2014) Daniel Plano et al. JOURNAL OF MEDICINAL CHEMISTRY
- Hybrids of Phenylsulfonylfuroxan and Coumarin as Potent Antitumor Agents
- (2014) Ming-Ming Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells
- (2014) Brian A. Wall et al. Pigment Cell & Melanoma Research
- Metabotropic Glutamate Receptor-1 as a Novel Target for the Antiangiogenic Treatment of Breast Cancer
- (2014) Cecilia L. Speyer et al. PLoS One
- Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
- (2013) Pascal Furet et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design and synthesis of novel 4-benzothiazole amino quinazolines Dasatinib derivatives as potential anti-tumor agents
- (2013) Jin Cai et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- BRAF inhibitors in cancer therapy
- (2013) Carolina Hertzman Johansson et al. PHARMACOLOGY & THERAPEUTICS
- Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
- (2012) Romeo Romagnoli et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
- (2012) Ian Bruce et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- An update on dual Src/Abl inhibitors
- (2012) Francesca Musumeci et al. Future Medicinal Chemistry
- An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site
- (2012) Yan Lu et al. PHARMACEUTICAL RESEARCH
- Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers
- (2011) Loren Laine et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents
- (2011) Dao Thi Kim Oanh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents
- (2011) Peng-Cheng Lv et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer
- (2011) Cecilia L. Speyer et al. BREAST CANCER RESEARCH AND TREATMENT
- Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells
- (2011) Myung-Joo Choi et al. CANCER LETTERS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Riluzole Enhances Ionizing Radiation-Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo
- (2011) A. J. Khan et al. CLINICAL CANCER RESEARCH
- Glutamatergic Pathway Targeting in Melanoma: Single-Agent and Combinatorial Therapies
- (2011) H. J. Lee et al. CLINICAL CANCER RESEARCH
- A Review of the Neural Mechanisms of Action and Clinical Efficiency of Riluzole in Treating Amyotrophic Lateral Sclerosis: What have we Learned in the Last Decade?
- (2010) Mark C. Bellingham CNS Neuroscience & Therapeutics
- Synthesis and Identification of a new class of antileukemic agents containing 2-(arylcarboxamide)-(S)-6-amino-4,5,6,7-tetrahydrobenzo[d]thiazole
- (2010) D.S. Prasanna et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-κB, AP-1 mediated transcription and eIF-4E mediated translational activation: Inhibitors of multi-pathways involve in cancer
- (2010) Rajan S. Giri et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity
- (2010) Valentin Zaharia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel dual Src/Abl inhibitors for hematologic and solid malignancies
- (2010) Silvia Schenone et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The Glutamate Release Inhibitor Riluzole Decreases Migration, Invasion, and Proliferation of Melanoma Cells
- (2010) Maithao N. Le et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Modes of Action of the New Arylguanidine Abafungin beyond Interference with Ergosterol Biosynthesis and in vitro Activity against Medically Important Fungi
- (2008) C. Borelli et al. CHEMOTHERAPY
- Targeting SphK1 as a New Strategy against Cancer
- (2008) Dai Shida et al. CURRENT DRUG TARGETS
- New Celecoxib Derivatives as Anti-Inflammatory Agents
- (2007) György Szabó et al. JOURNAL OF MEDICINAL CHEMISTRY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started