标题
Thiadiazole derivatives as anticancer agents
作者
关键词
-
出版物
Pharmacological Reports
Volume 72, Issue 5, Pages 1079-1100
出版商
Springer Science and Business Media LLC
发表日期
2020-09-03
DOI
10.1007/s43440-020-00154-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells
- (2020) Stella Cascioferro et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
- (2020) Danielly C. Ferraz da Costa et al. MOLECULES
- 3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma
- (2020) Stella Cascioferro et al. MOLECULES
- Targeting glutamine metabolism slows soft tissue sarcoma growth
- (2020) Pearl Lee et al. Nature Communications
- Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
- (2020) Ufuk Degirmenci et al. Cells
- The p38 Pathway: From Biology to Cancer Therapy
- (2020) Adrián Martínez-Limón et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Histone Deacetylase Inhibitors and Phenotypical Transformation of Cancer Cells
- (2019) Anna Wawruszak et al. Cancers
- Carbonic anhydrases as disease markers
- (2019) Sabina Zamanova et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Tubulin inhibitors as novel anticancer agents: an overview on patents (2013-2018)
- (2019) Kashif Haider et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Adjuvant chemotherapy in resected colon cancer: When, how and how long?
- (2019) Alain J. Gelibter et al. SURGICAL ONCOLOGY-OXFORD
- Dysregulation of glutaminase and glutamine synthetase in cancer
- (2019) José M. Matés et al. CANCER LETTERS
- Topoisomerases as anticancer targets
- (2018) Justine L. Delgado et al. BIOCHEMICAL JOURNAL
- Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability
- (2018) M.P. Narasimha Rao et al. BIOORGANIC CHEMISTRY
- Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation
- (2018) Elisabeth F. P. Peterse et al. BRITISH JOURNAL OF CANCER
- Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
- (2018) Qingqiu Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase
- (2018) Sarah C. Zimmermann et al. JOURNAL OF MEDICINAL CHEMISTRY
- Challenging transcription by DNA-binding antitumor drugs
- (2018) José Portugal BIOCHEMICAL PHARMACOLOGY
- Viewing the Eph receptors with a focus on breast cancer heterogeneity
- (2018) Ilias Nikas et al. CANCER LETTERS
- Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies
- (2018) Katarina Jakovljević et al. MedChemComm
- Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
- (2018) J. Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice
- (2018) Gunnar Boysen et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Synthesis, theoretical, spectroscopic and electrochemical DNA binding investigations of 1, 3, 4-thiadiazole derivatives of ibuprofen and ciprofloxacin: Cancer cell line studies
- (2018) Shahid Iqbal Farooqi et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells
- (2017) Ludovica Taglieri et al. INVESTIGATIONAL NEW DRUGS
- Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
- (2017) Mehlika Altıntop et al. MOLECULES
- Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies
- (2017) Tahir N. Sheikh et al. Oncotarget
- Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
- (2017) Milica Momcilovic et al. Cell Reports
- Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC
- (2016) Jae-Seon Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Design and evaluation of novel glutaminase inhibitors
- (2016) Lee A. McDermott et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and bioactivities of novel pyrazole oxime derivatives containing a 1,2,3-thiadiazole moiety
- (2016) Hong Dai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A phase 1 dose-escalation study of filanesib plus bortezomib and dexamethasone in patients with recurrent/refractory multiple myeloma
- (2016) Ajai Chari et al. CANCER
- Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents
- (2016) Hai-Wei Cui et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4
- (2016) Po-Lin Lin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy
- (2016) Stephanie M Myers et al. Future Medicinal Chemistry
- The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells
- (2016) Francesca De Iuliis et al. INVESTIGATIONAL NEW DRUGS
- Multifunctional Abl kinases in health and disease
- (2016) Aaditya Khatri et al. JOURNAL OF CELL SCIENCE
- Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination
- (2016) Ahmed Atef Ahmed Ali et al. PLoS One
- Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents
- (2015) Yu-Ru Lee et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma
- (2015) Celeste De Monte et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- 1,3,4-Thiadiazoles: A potent multi targeted pharmacological scaffold
- (2015) Saqlain Haider et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors
- (2015) Patricia M. LoRusso et al. INVESTIGATIONAL NEW DRUGS
- Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
- (2015) Yan Xiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles
- (2015) Tomasz Plech et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models
- (2015) X. S. Ye et al. MOLECULAR CANCER THERAPEUTICS
- Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies
- (2015) Alireza Aliabadi et al. DARU-Journal of Pharmaceutical Sciences
- Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo
- (2015) Shou-Hung Tang et al. Oncotarget
- Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif
- (2014) Peng Guan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors
- (2014) Hiroshi Wakui et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Synthesis and Biological Evaluation of Imidazo[2,1-b][1,3,4]thiadiazole-Linked Oxindoles as Potent Tubulin Polymerization Inhibitors
- (2014) Ahmed Kamal et al. ChemMedChem
- Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
- (2014) M. I. Gross et al. MOLECULAR CANCER THERAPEUTICS
- A Novel Compound NSC745885 Exerts an Anti-Tumor Effect on Tongue Cancer SAS Cells In Vitro and In Vivo
- (2014) Yuan-Wu Chen et al. PLoS One
- Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations
- (2013) Ashkan Emadi et al. EXPERIMENTAL HEMATOLOGY
- Synthesis, bioevaluation and docking study of 5-substitutedphenyl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents
- (2013) Nguyen-Hai Nam et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- 15-Lipoxygenases in cancer: A double-edged sword?
- (2013) Adi J. Klil-Drori et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
- (2012) Peng Guan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells
- (2012) M. Juszczak et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
- (2012) Anne Le et al. Cell Metabolism
- Thiadiazole-a Promising Structure in Medicinal Chemistry
- (2012) Yijing Li et al. ChemMedChem
- An update on dual Src/Abl inhibitors
- (2012) Francesca Musumeci et al. Future Medicinal Chemistry
- Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors
- (2012) Krupa Shukla et al. JOURNAL OF MEDICINAL CHEMISTRY
- Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors
- (2012) Swee Y. Sharp et al. PLoS One
- Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets
- (2011) Abdelrahman S. Mayhoub et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors
- (2011) Harish Rajak et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias
- (2011) Hanna Jean Khoury et al. CANCER
- The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells
- (2011) Małgorzata Juszczak et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell
- (2010) Junxia Wei et al. BMC CANCER
- Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
- (2010) M. J. Seltzer et al. CANCER RESEARCH
- Mcl-1 Stability Determines Mitotic Cell Fate of Human Multiple Myeloma Tumor Cells Treated with the Kinesin Spindle Protein Inhibitor ARRY-520
- (2010) B. J. Tunquist et al. MOLECULAR CANCER THERAPEUTICS
- Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues
- (2009) Hsu-Shan Huang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone
- (2009) Inga Cikotiene et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells
- (2009) R. Nakai et al. CANCER RESEARCH
- Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells
- (2009) B Z Carter et al. LEUKEMIA
- Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines
- (2008) Salwa M. I. Morsy et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents
- (2007) Marco Radi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now