Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review

Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents

(2019) Mohamed El-Naggar et al.   MOLECULES

Design and Synthesis of 1,3,4-Thiadiazole Derivatives as Novel Anticancer and Antitubercular Agents

(2019) D. Chandra Sekhar et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Synthesis and biological evaluation of novel disulfides incorporating 1,3,4-thiadiazole scaffold as promising antitumor agents

(2019) Sha Li et al.   MEDICINAL CHEMISTRY RESEARCH

Toward Rational Design of Novel Anti-Cancer Drugs Based on Targeting, Solubility, and Bioavailability Exemplified by 1,3,4-Thiadiazole Derivatives Synthesized Under Solvent-Free Conditions

(2019) Huda R.M. Rashdan et al.   MOLECULES

Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability

(2018) M.P. Narasimha Rao et al.   BIOORGANIC CHEMISTRY

Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity

(2018) Li Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antitumor and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives bearing disulfide bond

(2018) Hai-Ying Liu et al.   MEDICINAL CHEMISTRY RESEARCH

Utility of thiophene-2-carbonyl isothiocyanate as a precursor for the synthesis of 1,2,4-triazole, 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives with evaluation of their antitumor and antimicrobial activities

(2018) Ibrahim F. Nassar et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Synthesis and biological evaluation of some novel thiadiazole-benzofuran hybrids as potential antitumor agents

(2018) Abdou O. Abdelhamid et al.   SYNTHETIC COMMUNICATIONS

Antioxidant and anticancer activities of α-aminophosphonates containing thiadiazole moiety

(2018) Mohamed M. Azaam et al.   Journal of Saudi Chemical Society

Synthesis, theoretical, spectroscopic and electrochemical DNA binding investigations of 1, 3, 4-thiadiazole derivatives of ibuprofen and ciprofloxacin: Cancer cell line studies

(2018) Shahid Iqbal Farooqi et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives as Anticancer Agents

(2017) Zahra Rezaei et al.   Letters in Drug Design & Discovery

Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides

(2017) Eman Flefel et al.   MOLECULES

Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety

(2017) Mehlika Altıntop et al.   MOLECULES

Synthesis, characterization and anti cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

(2017) Deepak Chowrasia et al.   Arabian Journal of Chemistry

Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment

(2017) Vinit Raj et al.   Anti-Cancer Agents in Medicinal Chemistry

A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade

(2016) Raghu Ningegowda et al.   APOPTOSIS

Synthesis and SAR Study of the Novel Thiadiazole–Imidazole Derivatives as a New Anticancer Agents

(2016) Sobhi Mohamed Gomha et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents

(2016) Abdou Abdelhamid et al.   MOLECULES

One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents

(2016) Sobhi Gomha et al.   MOLECULES

Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents

(2016) Ali Almasirad et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Synthesis and evaluation of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties as new potential anti proliferative agents

(2015) Bandi Yadagiri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, in vitro anticancer and antimycobacterial evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino derivatives

(2015) Naveen Polkam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Antitumor Activities of Disulfide Derivatives Containing 1,3,4-Thiadiazole Moiety

(2015) Sha Li et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1- b ][1,3,4]thiadiazole and imidazo[2,1- b ][1,3]thiazole scaffolds

(2015) Romeo Romagnoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles

(2015) Tomasz Plech et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: Synthesis, cytotoxic activity and mechanism of action

(2014) Sujeet Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents

(2014) Sobhi M. Gomha et al.   MONATSHEFTE FUR CHEMIE

Discovery of 2-Phenyl-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)acetamide Derivatives as Apoptosis Inducers via the Caspase Pathway with Potential Anticancer Activity

(2013) Leila Hosseinzadeh et al.   ARCHIV DER PHARMAZIE

Synthesis and Biological Evaluation of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Potential Cytotoxic Agents

(2013) Yao-Jie Shi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis of some new pyrazole-based 1,3-thiazoles and 1,3,4-thiadiazoles as anticancer agents

(2013) Kamal M. Dawood et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells

(2013) Mahavir Chhajed et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents

(2012) Xian-Hui Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells

(2012) M. Juszczak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, biological evaluation and molecular docking studies of 1,3,4-thiadiazole derivatives containing 1,4-benzodioxan as potential antitumor agents

(2011) Juan Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cytotoxicity of New 5-Phenyl-4,5-dihydro-1,3,4-thiadiazole Analogues

(2011) Mohammad Sayed Alam et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents

(2011) Xin Jian Song et al.   CHINESE CHEMICAL LETTERS

Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo[2,1-b][1,3,4]-thiadiazole derivatives

(2011) Malleshappa N. Noolvi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents

(2011) Subhas S. Karki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells

(2011) Małgorzata Juszczak et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Design, synthesis and antitumor activity of C3/C3 bis-fluoroquonolones cross-linked with [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole

(2011) Guo-qiang Hu et al.   Acta Pharmaceutica Sinica B

Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I): Tethered with a fused heterocyclic s-triazolo[2,1-b][1,3,4]thiadiazole

(2010) Guo Qiang Hu et al.   CHINESE CHEMICAL LETTERS

Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles

(2010) Hemlata Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, antioxidant, and anticancer studies of 6-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole in HepG2 cell lines

(2010) Dhanya Sunil et al.   MEDICINAL CHEMISTRY RESEARCH

6-[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole as a potent antioxidant and an anticancer agent induces growth inhibition followed by apoptosis in HepG2 cells

(2010) Dhanya Sunil et al.   Arabian Journal of Chemistry

Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives

(2008) Mohammad Yusuf et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9′,2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-inflammatory agents

(2008) H.N. Hafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: Synthesis and in vitro biological evaluation

(2008) Fatemeh Poorrajab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines

(2008) Salwa M. I. Morsy et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones

(2007) Varsha Jatav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY