Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment

Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors

(2020) Ehab M. Gedawy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hypothyroidism: morphological and metabolic changes in the testis of adult albino rat and the amelioration by alpha lipoic acid

(2020) A. A. Ibrahim et al.   FOLIA MORPHOLOGICA

Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors

(2019) Ehab S. Taher et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists

(2019) Aliaa Abdelrahman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anticancer evaluation of novel 1,3-benzodioxoles and 1,4-benzodioxines

(2019) Rasha Mohamed Hassan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular modeling and preclinical evaluation of radioiodinated tenoxicam for inflammatory disease diagnosis

(2018) Tamer M. Sakr et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Thiazoles and Thiazolidinones as COX/LOX Inhibitors

(2018) et al.   MOLECULES

Anti-Inflammatory, Anti-Diabetic, and Anti-Alzheimer’s Effects of Prenylated Flavonoids from Okinawa Propolis: An Investigation by Experimental and Computational Studies

(2018) Md Shahinozzaman et al.   MOLECULES

Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation

(2018) Yomna I. Mahmoud et al.   BIOMEDICINE & PHARMACOTHERAPY

Quercetin from Polygonum capitatum Protects against Gastric Inflammation and Apoptosis Associated with Helicobacter pylori Infection by Affecting the Levels of p38MAPK, BCL-2 and BAX

(2017) Shu Zhang et al.   MOLECULES

Review: biologically active pyrazole derivatives

(2017) Anam Ansari et al.   NEW JOURNAL OF CHEMISTRY

Antioxidant potential, anti-inflammatory activity and gastroprotective mechanisms of Mallotus roxburghianus (Muell.) against ethanol-induced gastric ulcers in Wistar albino rats

(2017) Kumari Sagun et al.   Journal of Functional Foods

Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors

(2017) Deema A. Al-Turki et al.   SAUDI PHARMACEUTICAL JOURNAL

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Synthesis and in silico investigation of thiazoles bearing pyrazoles derivatives as anti-inflammatory agents

(2016) Rahul D. Kamble et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety

(2016) Catarina Pereira-Leite et al.   MEDICINAL RESEARCH REVIEWS

Combined effect of bone marrow derived mesenchymal stem cells and nitric oxide inducer on injured gastric mucosa in a rat model

(2016) Laila Rashed et al.   TISSUE & CELL

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

(2016) Md Jahangir Alam et al.   Drug Design Development and Therapy

The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats

(2015) Xiao-Ying Chen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists

(2014) Miriam Andrés et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

iLOGP: A Simple, Robust, and Efficient Description of n-Octanol/Water Partition Coefficient for Drug Design Using the GB/SA Approach

(2014) Antoine Daina et al.   Journal of Chemical Information and Modeling

From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

(2011) Santos Fustero et al.   CHEMICAL REVIEWS

Synthesis and anti-inflammatory activity of some pyrazole derivatives

(2011) Samir M. El-Moghazy et al.   MEDICINAL CHEMISTRY RESEARCH

A convenient and efficient synthesis of heteroaromatic hydrazone derivatives via cyclization of thiosemicarbazone with ω-bromoacetophenone

(2010) Weiwei Liu et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents

(2007) Adnan A. Bekhit et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY