Toward the equilibrium and kinetics of amyloid peptide self-assembly

On the Protein Fibrillation Pathway: Oligomer Intermediates Detection Using ATR-FTIR Spectroscopy

(2021) Jelica Milošević et al.   MOLECULES

Thermodynamics of amyloid fibril formation from non-equilibrium experiments of growth and dissociation

(2021) Rasmus K. Norrild et al.   BIOPHYSICAL CHEMISTRY

Tryptophan Probes of TDP-43 C-Terminal Domain Amyloid Formation

(2021) Sydney O. Shuster et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The human cathelicidin LL-37 is a nanomolar inhibitor of amyloid self-assembly of islet amyloid polypeptide (IAPP)

(2020) Valentina Armiento et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation

(2020) Nicklas Österlund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation–inert complex

(2020) Cecilia Wallin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

(2020) Thomas C. T. Michaels et al.   Nature Chemistry

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

(2020) Mattias Törnquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth

(2020) Juami Hermine Mariama van Gils et al.   PLoS Computational Biology

Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial

(2020) Katarina Siposova et al.   ACS Applied Materials & Interfaces

Simultaneous detection of tyrosine and structure‐specific intrinsic fluorescence in the fibrillation of Alzheimer’s associated peptides

(2020) Anurag Singh et al.   CHEMPHYSCHEM

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

(2020) William E. Arter et al.   NANO LETTERS

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

(2020) Sara Linse et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils

(2020) Dev Thacker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Division of Amyloid Fibrils: Systematic Comparison of Fibril Fragmentation Stability by Linking Theory with Experiments

(2020) David M. Beal et al.   iScience

Visualizing and trapping transient oligomers in amyloid assembly pathways

(2020) Emma E. Cawood et al.   BIOPHYSICAL CHEMISTRY

Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules

(2020) Emma E. Cawood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments

(2020) Pedro M. Martins et al.   Frontiers in Molecular Neuroscience

Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

(2020) Katiuscia Pagano et al.   Frontiers in Neuroscience

Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins

(2020) Sabine M. Ulamec et al.   Frontiers in Neuroscience

Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR

(2019) Samuel A. Kotler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic phase diagram of amyloid-β (16–22) peptide

(2019) Yiming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5–42

(2019) Tanja Weiffert et al.   ACS Chemical Neuroscience

Native Ion Mobility-Mass Spectrometry reveals the formation of β-barrel shaped Amyloid-β hexamers in a membrane-mimicking environment

(2019) Nicklas Österlund et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans

(2019) Romain F. Laine et al.   ACS Chemical Biology

The molecular lifecycle of amyloid – Mechanism of assembly, mesoscopic organisation, polymorphism, suprastructures, and biological consequences

(2019) Liisa Lutter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Thermophoretic trap for single amyloid fibril and protein aggregation studies

(2019) Martin Fränzl et al.   NATURE METHODS

Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β40 (Aβ40) by the peptide fragment Aβ16–22

(2019) Samuel J. Bunce et al.   Science Advances

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

(2019) Emil Dandanell Agerschou et al.   eLife

Label-Free Analysis of Protein Aggregation and Phase Behavior

(2019) Zenon Toprakcioglu et al.   ACS Nano

The growth of amyloid fibrils: rates and mechanisms

(2019) Alexander K. Buell   BIOCHEMICAL JOURNAL

Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data

(2019) Kristine Steen Jensen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements

(2018) Anna Spanopoulou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Secondary nucleation in amyloid formation

(2018) Mattias Törnquist et al.   CHEMICAL COMMUNICATIONS

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

(2018) Samuel I. A. Cohen et al.   Nature Chemistry

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

(2018) Johnny Habchi et al.   Nature Chemistry

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

(2018) Xiaoting Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative mass imaging of single biological macromolecules

(2018) Gavin Young et al.   SCIENCE

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

(2018) Ingrid M. van der Wateren et al.   Chemical Science

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multi-parametric imaging

(2018) Meng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging Aβ(1–42) fibril elongation reveals strongly polarised growth and growth incompetent states

(2017) Laurence J. Young et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

(2017) Anna Munke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

(2017) Georg Meisl et al.   Chemical Science

Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways

(2017) C. Dammers et al.   Chemical Science

Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

(2016) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Hsp90 directly interacts, in vitro , with amyloid structures and modulates their assembly and disassembly

(2016) Claire Schirmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Comparison of the aggregation of homologous β 2 -microglobulin variants reveals protein solubility as a key determinant of amyloid formation

(2016) Clare L. Pashley et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils

(2016) Nadezhda Nespovitaya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ionic Strength Modulation of the Free Energy Landscape of Aβ40 Peptide Fibril Formation

(2016) Axel Abelein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

(2016) Patrick Flagmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

(2016) Céline Galvagnion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

(2016) Georg Meisl et al.   Scientific Reports

Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers

(2015) Mathew H. Horrocks et al.   ANALYTICAL CHEMISTRY

Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered

(2015) Jamshed Anwar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterogeneity and Turnover of Intermediates during Amyloid-β (Aβ) Peptide Aggregation Studied by Fluorescence Correlation Spectroscopy

(2015) Ann Tiiman et al.   BIOCHEMISTRY

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates

(2015) Hamid Shirani et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

(2015) Olga Szczepankiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

(2015) Axel Abelein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of amyloid formation revealed by solution NMR

(2015) Theodoros K. Karamanos et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation

(2015) Risto Cukalevski et al.   Chemical Science

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Generic Method for Design of Oligomer-Specific Antibodies

(2014) Kristoffer Brännström et al.   PLoS One

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein amyloids develop an intrinsic fluorescence signature during aggregation

(2013) Fiona T. S. Chan et al.   ANALYST

Electrostatic Effects in Filamentous Protein Aggregation

(2013) Alexander K. Buell et al.   BIOPHYSICAL JOURNAL

A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence

(2013) Dorothea Pinotsi et al.   CHEMBIOCHEM

Quantification of the Concentration of Aβ42 Propagons during the Lag Phase by an Amyloid Chain Reaction Assay

(2013) Paolo Arosio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

(2013) Dorothea Pinotsi et al.   NANO LETTERS

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

(2012) Alexander K. Buell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Amyloid Formation

(2012) Torleif Härd et al.   JOURNAL OF MOLECULAR BIOLOGY

Probing exchange kinetics and atomic resolution dynamics in high-molecular-weight complexes using dark-state exchange saturation transfer NMR spectroscopy

(2012) Nicolas L Fawzi et al.   Nature Protocols

Kinetic Profile of Amyloid Formation in the Presence of an Aromatic Inhibitor by Nuclear Magnetic Resonance

(2012) Gai Liu et al.   ACS Medicinal Chemistry Letters

Interactions between a luminescent conjugated polyelectrolyte and amyloid fibrils investigated with flow linear dichroism spectroscopy

(2011) Jens Wigenius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Probing small molecule binding to amyloid fibrils

(2011) Alexander K. Buell et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Surface Attachment of Protein Fibrils via Covalent Modification Strategies

(2010) Alexander K. Buell et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

(2009) Andreas Åslund et al.   ACS Chemical Biology

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

In vitro amyloid Aβ1-42 peptide aggregation monitoring by asymmetrical flow field-flow fractionation with multi-angle light scattering detection

(2009) Diana C. Rambaldi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Biosensor-based label-free assays of amyloid growth

(2009) Duncan A. White et al.   FEBS LETTERS

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

(2008) Vicki Betts et al.   NEUROBIOLOGY OF DISEASE

Direct characterization of amyloidogenic oligomers by single-molecule fluorescence

(2008) A. Orte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA