标题
Visualizing and trapping transient oligomers in amyloid assembly pathways
作者
关键词
Amyloid disease, Transient intermediate, Oligomer stabilization, Chemical tool, NMR, Single particle
出版物
BIOPHYSICAL CHEMISTRY
Volume 268, Issue -, Pages 106505
出版商
Elsevier BV
发表日期
2020-11-11
DOI
10.1016/j.bpc.2020.106505
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Using protein engineering to understand and modulate aggregation
- (2020) Jessica S Ebo et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Structural Characterization of Individual α-Synuclein Oligomers Formed at Different Stages of Protein Aggregation by Atomic Force Microscopy-Infrared Spectroscopy
- (2020) Lei Zhou et al. ANALYTICAL CHEMISTRY
- Out-of-register parallel β-sheets and antiparallel β-sheets coexist in 150 kDa oligomers formed by Amyloid-β(1-42)
- (2020) Yuan Gao et al. JOURNAL OF MOLECULAR BIOLOGY
- Spot the Difference: Function versus Toxicity in Amyloid Fibrils
- (2020) Sabine M. Ulamec et al. TRENDS IN BIOCHEMICAL SCIENCES
- Applications of Mass Spectrometry in the Onset of Amyloid Fibril Formation: Focus on the Analysis of Early-Stage Oligomers
- (2020) Jiaojiao Hu et al. Frontiers in Chemistry
- Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
- (2020) Francesco A. Aprile et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
- (2020) Sonia Ciudad et al. Nature Communications
- AFM Probing of Amyloid-Beta 42 Dimers and Trimers
- (2020) Sibaprasad Maity et al. Frontiers in Molecular Biosciences
- Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules
- (2020) Emma E. Cawood et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease
- (2019) Suman De et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Role of domain interactions in the aggregation of full-length immunoglobulin light chains
- (2019) Enrico Rennella et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A molecular mechanism for transthyretin amyloidogenesis
- (2019) Ai Woon Yee et al. Nature Communications
- Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR
- (2019) Samuel A. Kotler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Site-Directed Fragment-Based Screening for the Discovery of Protein–Protein Interaction Stabilizers
- (2019) Eline Sijbesma et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Atomic force microscopy for single molecule characterisation of protein aggregation
- (2019) Francesco Simone Ruggeri et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- The toxicity of misfolded protein oligomers is independent of their secondary structure
- (2019) Mirella Vivoli Vega et al. ACS Chemical Biology
- An NMR View of Protein Dynamics in Health and Disease
- (2019) Ashok Sekhar et al. Annual Review of Biophysics
- Covalent Inhibitors of Protein–Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues
- (2019) Luca Gambini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Stabilization of amyloidogenic immunoglobulin light chains by small molecules
- (2019) Gareth J. Morgan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling
- (2019) Bonnie J. Murphy et al. SCIENCE
- A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease
- (2019) Ebrima Gibbs et al. Scientific Reports
- Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β40 (Aβ40) by the peptide fragment Aβ16–22
- (2019) Samuel J. Bunce et al. Science Advances
- Probing the Basis of α-Synuclein Aggregation by Comparing Simulations to Single-Molecule Experiments
- (2019) Cassandra D.M. Churchill et al. BIOPHYSICAL JOURNAL
- Observation of β-Amyloid Peptide Oligomerization by Pressure-Jump NMR Spectroscopy
- (2019) C. Ashley Barnes et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural mapping of oligomeric intermediates in an amyloid assembly pathway
- (2019) Theodoros K Karamanos et al. eLife
- Application of native mass spectrometry in studying intrinsically disordered proteins: A special focus on neurodegenerative diseases
- (2019) Gopa Mitra BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- A Genetically Encoded Diazirine Analogue for RNA–Protein Photo‐crosslinking
- (2019) Dmytro Dziuba et al. CHEMBIOCHEM
- Emerging consensus on the collapse of unfolded and intrinsically disordered proteins in water
- (2019) Robert B Best CURRENT OPINION IN STRUCTURAL BIOLOGY
- Unveiling invisible protein states with NMR spectroscopy
- (2019) T Reid Alderson et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Amyloid structures: much more than just a cross-β fold
- (2019) Rodrigo Gallardo et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions
- (2018) Benedetta Mannini et al. ACS Chemical Neuroscience
- Oligomer Diversity during the Aggregation of the Repeat Region of Tau
- (2018) Magnus Kjaergaard et al. ACS Chemical Neuroscience
- Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading
- (2018) Franziska Kundel et al. ACS Chemical Neuroscience
- Pulsed Hydrogen–Deuterium Exchange Illuminates the Aggregation Kinetics of α-Synuclein, the Causative Agent for Parkinson’s Disease
- (2018) Eva Illes-Toth et al. ACS Chemical Neuroscience
- A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers
- (2018) Judith M. Silverman et al. ACS Chemical Neuroscience
- Probing Intermolecular Interactions within the Amyloid β Trimer Using a Tethered Polymer Nanoarray
- (2018) Sibaprasad Maity et al. BIOCONJUGATE CHEMISTRY
- Effects of charge and hydrophobicity on the oligomerization of peptides derived from IAPP
- (2018) Yilin Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Covalent chemical co-chaperones of the p300/CBP GACKIX domain
- (2018) Jean M Lodge et al. CHEMBIOCHEM
- Structural differences between toxic and nontoxic HypF-N oligomers
- (2018) Claudia Capitini et al. CHEMICAL COMMUNICATIONS
- Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR
- (2018) Alberto Ceccon et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Probing Conformational Exchange in Weakly Interacting, Slowly Exchanging Protein Systems via Off-Resonance R1ρ Experiments: Application to Studies of Protein Phase Separation
- (2018) Tairan Yuwen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Hetero-oligomeric Amyloid Assembly and Mechanism: Prion Fragment PrP(106-126) Catalyzes the Islet Amyloid Polypeptide β-Hairpin
- (2018) Alexandre Iourievich Ilitchev et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Controlling the Oligomerization State of Aβ-Derived Peptides with Light
- (2018) Patrick J. Salveson et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2
- (2018) Jie Yang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases
- (2018) Nunilo Cremades et al. NEUROBIOLOGY OF DISEASE
- Effects of maturation on the conformational free-energy landscape of SOD1
- (2018) Robert M. Culik et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
- (2018) Xiaoting Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides
- (2018) Ciaran P. A. Doherty et al. PROTEIN SCIENCE
- Toward dynamic structural biology: Two decades of single-molecule Förster resonance energy transfer
- (2018) Eitan Lerner et al. SCIENCE
- Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
- (2018) Melissa Birol et al. Nature Communications
- Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
- (2018) Daniel R. Whiten et al. Cell Reports
- A new era for understanding amyloid structures and disease
- (2018) Matthew G. Iadanza et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions
- (2018) Kaja Przygońska et al. PLoS One
- Quantifying Co-Oligomer Formation by α-Synuclein
- (2018) Marija Iljina et al. ACS Nano
- Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues
- (2018) Alberto Dal Corso et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers
- (2018) Jim E. Horne et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- How Fluorescent Tags Modify Oligomer Size Distributions of the Alzheimer Peptide
- (2018) Jana Wägele et al. BIOPHYSICAL JOURNAL
- Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide
- (2017) Asa Hatami et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR
- (2017) Jobin Varkey et al. JOURNAL OF MAGNETIC RESONANCE
- A Tetramer Derived from Islet Amyloid Polypeptide
- (2017) Yilin Wang et al. JOURNAL OF ORGANIC CHEMISTRY
- Foldamer-Mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity
- (2017) Sunil Kumar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- α-Helix Mimetics as Modulators of Aβ Self-Assembly
- (2017) Sunil Kumar et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- NFGAIL Amyloid Oligomers: The Onset of Beta-Sheet Formation and the Mechanism for Fibril Formation
- (2017) Waldemar Hoffmann et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Single-molecule probing of amyloid nano-ensembles using the polymer nanoarray approach
- (2017) Sibaprasad Maity et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
- (2017) Giuliana Fusco et al. SCIENCE
- Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers
- (2017) Lydia M. Young et al. Chemical Science
- Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation
- (2017) Ricardo Sant’Anna et al. Scientific Reports
- Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
- (2017) Francesco A. Aprile et al. Science Advances
- Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates
- (2017) Fabio Castello et al. Scientific Reports
- Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
- (2016) Mathew H. Horrocks et al. ACS Chemical Neuroscience
- Single-Molecule FRET Spectroscopy and the Polymer Physics of Unfolded and Intrinsically Disordered Proteins
- (2016) Benjamin Schuler et al. Annual Review of Biophysics
- Conformational selection in amyloid-based immunotherapy: Survey of crystal structures of antibody-amyloid complexes
- (2016) Buyong Ma et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Covalent Tethering and Residues with Bulky Hydrophobic Side Chains Enable Self-Assembly of Distinct Amyloid Structures
- (2016) Jérémy Ruiz et al. CHEMBIOCHEM
- An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations
- (2016) Luitgard Nagel-Steger et al. CHEMBIOCHEM
- AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species
- (2016) Francesco Simone Ruggeri et al. CURRENT PHARMACEUTICAL DESIGN
- Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer’s Disease Immunotherapy
- (2016) Jing Liu et al. DRUGS & AGING
- Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate
- (2016) Kathrin Andrich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Power of Force: Insights into the Protein Folding Process Using Single-Molecule Force Spectroscopy
- (2016) Jörg Schönfelder et al. JOURNAL OF MOLECULAR BIOLOGY
- Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid
- (2016) Nicholas L. Truex et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1–42 Aggregation
- (2016) Ke Sherry Li et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Native Mass Spectrometry: What is in the Name?
- (2016) Aneika C. Leney et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain
- (2016) Gizem Akçay et al. Nature Chemical Biology
- An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies
- (2016) Jongcheol Seo et al. Nature Chemistry
- Allosteric inhibition of antiapoptotic MCL-1
- (2016) Susan Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
- (2016) Marija Iljina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exploring the aggregation free energy landscape of the amyloid-β protein (1–40)
- (2016) Weihua Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments
- (2016) Montserrat Serra-Batiste et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
- (2016) Johnny Habchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy
- (2016) Ashok Sekhar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
- (2016) T. H. Wright et al. SCIENCE
- Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
- (2016) Ricardo Sant'Anna et al. Nature Communications
- Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein
- (2016) Amar Nath Gupta et al. Nature Communications
- Foldamer-mediated manipulation of a pre-amyloid toxin
- (2016) Sunil Kumar et al. Nature Communications
- Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping
- (2016) Marie N. Bongiovanni et al. Nature Communications
- Structural basis of synaptic vesicle assembly promoted by α-synuclein
- (2016) Giuliana Fusco et al. Nature Communications
- Allosteric inhibition of antiapoptotic MCL-1
- (2016) Susan Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Nanoscale studies link amyloid maturity with polyglutamine diseases onset
- (2016) F. S. Ruggeri et al. Scientific Reports
- Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
- (2016) Marija Iljina et al. Scientific Reports
- Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
- (2016) Andisheh Abedini et al. eLife
- Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
- (2016) Elisa Evangelisti et al. Scientific Reports
- Extraction of Accurate Biomolecular Parameters from Single-Molecule Force Spectroscopy Experiments
- (2015) Oliver E. Farrance et al. ACS Nano
- Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers
- (2015) Mathew H. Horrocks et al. ANALYTICAL CHEMISTRY
- Distinct higher-order α-synuclein oligomers induce intracellular aggregation
- (2015) Eva Illes-Toth et al. BIOCHEMICAL JOURNAL
- Design and Characterization of Chemically Stabilized Aβ42 Oligomers
- (2015) Ghiam Yamin et al. BIOCHEMISTRY
- Continuous and Pulsed Hydrogen–Deuterium Exchange and Mass Spectrometry Characterize CsgE Oligomerization
- (2015) Hanliu Wang et al. BIOCHEMISTRY
- A Flexible Nanoarray Approach for the Assembly and Probing of Molecular Complexes
- (2015) Alexey V. Krasnoslobodtsev et al. BIOPHYSICAL JOURNAL
- Structural, morphological, and functional diversity of amyloid oligomers
- (2015) Leonid Breydo et al. FEBS LETTERS
- Uncovering the Early Assembly Mechanism for Amyloidogenic β2-Microglobulin Using Cross-linking and Native Mass Spectrometry
- (2015) Zoe Hall et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stabilization of Nontoxic A -Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease
- (2015) T. M. Ryan et al. JOURNAL OF NEUROSCIENCE
- X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin
- (2015) Ryan K. Spencer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion
- (2015) Charlotte A. Scarff et al. MOLECULAR & CELLULAR PROTEOMICS
- Prolonged and tunable residence time using reversible covalent kinase inhibitors
- (2015) J Michael Bradshaw et al. Nature Chemical Biology
- Site-selective protein-modification chemistry for basic biology and drug development
- (2015) Nikolaus Krall et al. Nature Chemistry
- Isolation and characterization of antibody fragments selective for toxic oligomeric tau
- (2015) Huilai Tian et al. NEUROBIOLOGY OF AGING
- Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders
- (2015) Elvira Valera et al. Neurotherapeutics
- Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
- (2015) Serene W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers
- (2015) Kevin W. Tipping et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape
- (2015) Hao Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms of amyloid formation revealed by solution NMR
- (2015) Theodoros K. Karamanos et al. PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
- Visualizing transient dark states by NMR spectroscopy
- (2015) Nicholas J. Anthis et al. QUARTERLY REVIEWS OF BIOPHYSICS
- A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease
- (2015) Michael W. Beck et al. Chemical Science
- A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
- (2015) Sarah L. Shammas et al. Nature Communications
- Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation
- (2015) F. S. Ruggeri et al. Nature Communications
- Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein
- (2015) Maria K. Janowska et al. Scientific Reports
- Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
- (2015) Laura Tosatto et al. Scientific Reports
- Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways
- (2015) Ashok Sekhar et al. eLife
- Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain
- (2015) Boris Brumshtein et al. eLife
- Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity
- (2014) Benedetta Mannini et al. ACS Chemical Biology
- Co-existence of Two Different α-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2014) Wojciech Paslawski et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils
- (2014) Christofer Lendel et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR
- (2014) Rina Rosenzweig et al. Annual Review of Biochemistry
- Capping of Aβ42 Oligomers by Small Molecule Inhibitors
- (2014) Ziao Fu et al. BIOCHEMISTRY
- Antibodies and protein misfolding: From structural research tools to therapeutic strategies
- (2014) Erwin De Genst et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Early amyloid β-protein aggregation precedes conformational change
- (2014) Bogdan Barz et al. CHEMICAL COMMUNICATIONS
- Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality
- (2014) Michelle R. Arkin et al. CHEMISTRY & BIOLOGY
- Structural Insights into Amyloid Oligomers of the Parkinson Disease-related Protein α-Synuclein
- (2014) J. Ignacio Gallea et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants
- (2014) Thanh D. Do et al. JOURNAL OF PHYSICAL CHEMISTRY B
- The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
- (2014) Nikolai Lorenzen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Visualization of Transient Protein-Protein Interactions that Promote or Inhibit Amyloid Assembly
- (2014) Theodoros K. Karamanos et al. MOLECULAR CELL
- Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry
- (2014) Lydia M. Young et al. Nature Chemistry
- Single-Molecule Force Spectroscopy of Rapidly Fluctuating, Marginally Stable Structures in the Intrinsically Disordered Proteinα-Synuclein
- (2014) Allison Solanki et al. PHYSICAL REVIEW LETTERS
- Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand
- (2014) N. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FP tethering: a screening technique to rapidly identify compounds that disrupt protein–protein interactions
- (2014) Jean M. Lodge et al. MedChemComm
- Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy
- (2013) Robert Tycko et al. ACCOUNTS OF CHEMICAL RESEARCH
- Analysis of Amyloid Nanostructures Using Photo-cross-linking: In Situ Comparison of Three Widely Used Photo-cross-linkers
- (2013) George W. Preston et al. ACS Chemical Biology
- Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution
- (2013) Mathew H. Horrocks et al. ANALYTICAL CHEMISTRY
- Characterizing the Dynamics of α-Synuclein Oligomers Using Hydrogen/Deuterium Exchange Monitored by Mass Spectrometry
- (2013) Simon Mysling et al. BIOCHEMISTRY
- α-Synuclein Misfolding Assessed with Single Molecule AFM Force Spectroscopy: Effect of Pathogenic Mutations
- (2013) Alexey V. Krasnoslobodtsev et al. BIOCHEMISTRY
- Photo-induced covalent cross-linking for the analysis of biomolecular interactions
- (2013) George W. Preston et al. CHEMICAL SOCIETY REVIEWS
- Recipe for β-Sheets: Foldamers Containing Amyloidogenic Peptide Sequences
- (2013) Ryan Spencer et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Oligomeric States along the Folding Pathways of β2-Microglobulin: Kinetics, Thermodynamics, and Structure
- (2013) E. Rennella et al. JOURNAL OF MOLECULAR BIOLOGY
- Dissection of Conformational Conversion Events during Prion Amyloid Fibril Formation Using Hydrogen Exchange and Mass Spectrometry
- (2013) Jogender Singh et al. JOURNAL OF MOLECULAR BIOLOGY
- Factors That Drive Peptide Assembly and Fibril Formation: Experimental and Theoretical Analysis of Sup35 NNQQNY Mutants
- (2013) Thanh D. Do et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Ordering a Dynamic Protein Via a Small-Molecule Stabilizer
- (2013) Ningkun Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Dynamic Structure of α-Synuclein Multimers
- (2013) Thomas Gurry et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors
- (2013) Lydia M. Young et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry
- (2013) Aneika C. Leney et al. Molecular BioSystems
- Nanoprobing of misfolding and interactions of amyloid β 42 protein
- (2013) Bo-Hyun Kim et al. Nanomedicine-Nanotechnology Biology and Medicine
- Single-molecule assays for investigating protein misfolding and aggregation
- (2013) Armin Hoffmann et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation
- (2013) Ying Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of amyloid β−protein dimerization determined using single−molecule AFM force spectroscopy
- (2013) Zhengjian Lv et al. Scientific Reports
- Familial Alzheimer’s Disease Mutations Differentially Alter Amyloid β-Protein Oligomerization
- (2012) Megan Murray Gessel et al. ACS Chemical Neuroscience
- Covalent Cross-Linking within Supramolecular Peptide Structures
- (2012) George W. Preston et al. ANALYTICAL CHEMISTRY
- Molecular Composition of Sub-stoichiometrically Labeled α-Synuclein Oligomers Determined by Single-Molecule Photobleaching
- (2012) Niels Zijlstra et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure
- (2012) María Soledad Celej et al. BIOCHEMICAL JOURNAL
- Continuous Flow Reactor for the Production of Stable Amyloid Protein Oligomers
- (2012) Eric Yale Hayden et al. BIOCHEMISTRY
- Structure and Dynamics of Small Soluble Aβ(1–40) Oligomers Studied by Top-Down Hydrogen Exchange Mass Spectrometry
- (2012) Jingxi Pan et al. BIOCHEMISTRY
- Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly
- (2012) L.A. Woods et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
- (2012) Nunilo Cremades et al. CELL
- Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases
- (2012) John H. Viles COORDINATION CHEMISTRY REVIEWS
- Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity
- (2012) Ali Reza A. Ladiwala et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers
- (2012) Juan Miguel Lopez del Amo et al. JOURNAL OF MOLECULAR BIOLOGY
- Nanoprobing of the Effect of Cu2+ Cations on Misfolding, Interaction and Aggregation of Amyloid β Peptide
- (2012) Zhengjian Lv et al. Journal of Neuroimmune Pharmacology
- Effect of electrostatics on aggregation of prion protein Sup35 peptide
- (2012) Alexander M Portillo et al. JOURNAL OF PHYSICS-CONDENSED MATTER
- Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein
- (2012) Alexey V. Krasnoslobodtsev et al. PLoS One
- Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
- (2012) I. Morgado et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rational design of potent domain antibody inhibitors of amyloid fibril assembly
- (2012) A. R. A. Ladiwala et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
- (2012) C. E. Bulawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aβ(39–42) Modulates Aβ Oligomerization but Not Fibril Formation
- (2011) Megan Murray Gessel et al. BIOCHEMISTRY
- Structural Insights into the Pre-Amyloid Tetramer of β-2-Microglobulin from Covalent Labeling and Mass Spectrometry
- (2011) Vanessa Leah Mendoza et al. BIOCHEMISTRY
- Single-Molecule Atomic Force Microscopy Force Spectroscopy Study of Aβ-40 Interactions
- (2011) Bo-Hyun Kim et al. BIOCHEMISTRY
- Structure and Dynamics of Oligomeric Intermediates in β2-Microglobulin Self-Assembly
- (2011) David P. Smith et al. BIOPHYSICAL JOURNAL
- Transmission electron microscopy characterization of fluorescently labelled amyloid β 1-40 and α-synuclein aggregates
- (2011) Valerie L Anderson et al. BMC BIOTECHNOLOGY
- Ion Mobility Separation Coupled with MS Detects Two Structural States of Alzheimer's Disease Aβ1–40 Peptide Oligomers
- (2011) Marcin Kłoniecki et al. JOURNAL OF MOLECULAR BIOLOGY
- Crystal Structure of the Amyloid- p3 Fragment Provides a Model for Oligomer Formation in Alzheimer's Disease
- (2011) V. A. Streltsov et al. JOURNAL OF NEUROSCIENCE
- Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics
- (2011) Cong Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR
- (2011) Nicolas L. Fawzi et al. NATURE
- The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide
- (2011) Priyanka Narayan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Familial Parkinson disease mutations influence α-synuclein assembly
- (2011) Kenjiro Ono et al. NEUROBIOLOGY OF DISEASE
- Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant
- (2011) K. Domanska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-based design of conformation- and sequence-specific antibodies against amyloid
- (2011) J. M. Perchiacca et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange
- (2010) Natàlia Carulla et al. ACCOUNTS OF CHEMICAL RESEARCH
- Characterizing Early Aggregates Formed by an Amyloidogenic Peptide by Mass Spectrometry
- (2010) Harriet L. Cole et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Structure of the Preamyloid Dimer of β-2-Microglobulin from Covalent Labeling and Mass Spectrometry
- (2010) Vanessa Leah Mendoza et al. BIOCHEMISTRY
- Transmembrane Structures for Alzheimer’s Aβ1−42Oligomers
- (2010) Birgit Strodel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Detection of Transient Interchain Interactions in the Intrinsically Disordered Protein α-Synuclein by NMR Paramagnetic Relaxation Enhancement
- (2010) Kuen-Phon Wu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nanoprobing of α-synuclein misfolding and aggregation with atomic force microscopy
- (2010) Junping Yu et al. Nanomedicine-Nanotechnology Biology and Medicine
- Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma
- (2010) Sungwook Choi et al. Nature Chemical Biology
- A causative link between the structure of aberrant protein oligomers and their toxicity
- (2010) Silvia Campioni et al. Nature Chemical Biology
- Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation
- (2010) Christian Bleiholder et al. Nature Chemistry
- Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research
- (2010) Asad Jan et al. Nature Protocols
- Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils
- (2010) Mahiuddin Ahmed et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Metal binding sheds light on mechanisms of amyloid assembly
- (2010) Matthew F. Calabrese et al. Prion
- Elongated oligomers in 2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry
- (2010) D. P. Smith et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements
- (2010) N. L. Fawzi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nanoimaging for protein misfolding diseases
- (2010) Yuri L. Lyubchenko et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Genetically encoding an aliphatic diazirine for protein photocrosslinking
- (2010) Chungjung Chou et al. Chemical Science
- Lipid bilayer disruption by oligomeric α-synuclein depends on bilayer charge and accessibility of the hydrophobic core
- (2009) Bart D. van Rooijen et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Probing Neuroserpin Polymerization and Interaction with Amyloid-β Peptides Using Single Molecule Fluorescence
- (2009) Albert Chiou et al. BIOPHYSICAL JOURNAL
- Theory, Practice, and Applications of Paramagnetic Relaxation Enhancement for the Characterization of Transient Low-Population States of Biological Macromolecules and Their Complexes
- (2009) G. Marius Clore et al. CHEMICAL REVIEWS
- Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein
- (2009) Sharareh Emadi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation
- (2009) Jessica W. Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Competition between Intramolecular and Intermolecular Interactions in an Amyloid-Forming Protein
- (2009) Katy E. Routledge et al. JOURNAL OF MOLECULAR BIOLOGY
- Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
- (2009) Summer L. Bernstein et al. Nature Chemistry
- Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation
- (2009) N. Carulla et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-neurotoxicity relationships of amyloid -protein oligomers
- (2009) K. Ono et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation
- (2008) David P. Smith et al. CHEMICAL COMMUNICATIONS
- Structural Classification of Toxic Amyloid Oligomers
- (2008) Charles G. Glabe JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein Misfolding: Single Molecule AFM Force Spectroscopy Study
- (2008) Junping Yu et al. JOURNAL OF MOLECULAR BIOLOGY
- Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein
- (2008) Dong-Pyo Hong et al. JOURNAL OF MOLECULAR BIOLOGY
- Early Stages for Parkinson’s Development: α-Synuclein Misfolding and Aggregation
- (2008) Junping Yu et al. Journal of Neuroimmune Pharmacology
- Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
- (2008) Keir C Neuman et al. NATURE METHODS
- A regulatable switch mediates self-association in an immunoglobulin fold
- (2008) Matthew F Calabrese et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Direct characterization of amyloidogenic oligomers by single-molecule fluorescence
- (2008) A. Orte et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer's Disease Amyloid-β Peptide
- (2007) Deborah J. Tew et al. BIOPHYSICAL JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started