期刊
CHEMICAL SCIENCE
卷 8, 期 6, 页码 4352-4362出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc00215g
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资金
- European Research Council under the European Union's Seventh Framework Programme (FP7) through the ERC grant PhysProt [337969]
- Sidney Sussex College Cambridge
- Frances and Augusta Newman Foundation
- Biotechnology and Biological Science Research Council
- Swedish research Council
- China Scholarship Council
The aggregation of the amyloid beta peptide (A beta 42), which is linked to Alzheimer's disease, can be altered significantly by modulations of the peptide's intermolecular electrostatic interactions. Variations in sequence and solution conditions have been found to lead to highly variable aggregation behaviour. Here we modulate systematically the electrostatic interactions governing the aggregation kinetics by varying the ionic strength of the solution. We find that changes in the solution ionic strength induce a switch in the reaction pathway, altering the dominant mechanisms of aggregate multiplication. This strategy thereby allows us to continuously sample a large space of different reaction mechanisms and develop a minimal reaction network that unifies the experimental kinetics under a wide range of different conditions. More generally, this universal reaction network connects previously separate systems, such as charge mutants of the A beta 42 peptide, on a continuous mechanistic landscape, providing a unified picture of the aggregation mechanism of A beta 42.
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