The growth of amyloid fibrils: rates and mechanisms

Physical Determinants of Amyloid Assembly in Biofilm Formation

(2019) Maria Andreasen et al.   mBio

Rapid and inefficient kinetics of sickle hemoglobin fiber growth

(2019) Brian T. Castle et al.   Science Advances

Mechanism of amyloid protein aggregation and the role of inhibitors

(2019) Sara Linse   PURE AND APPLIED CHEMISTRY

Steady, Symmetric, and Reversible Growth and Dissolution of Individual Amyloid-β Fibrils

(2019) Yuechuan Xu et al.   ACS Chemical Neuroscience

Thermophoretic trap for single amyloid fibril and protein aggregation studies

(2019) Martin Fränzl et al.   NATURE METHODS

Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism

(2019) Paramita Chaudhuri et al.   AGEING RESEARCH REVIEWS

Structural mapping of oligomeric intermediates in an amyloid assembly pathway

(2019) Theodoros K Karamanos et al.   eLife

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

(2019) Emil Dandanell Agerschou et al.   eLife

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

(2019) Christine Röder et al.   Nature Communications

Inhibition of α-Synuclein Amyloid Fibril Elongation by Blocking Fibril Ends

(2018) Volodymyr V. Shvadchak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

(2018) Samuel I. A. Cohen et al.   Nature Chemistry

Quantitative mass imaging of single biological macromolecules

(2018) Gavin Young et al.   SCIENCE

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

(2018) Ingrid M. van der Wateren et al.   Chemical Science

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

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(2018)   ADVANCED MATERIALS

Protein Co-Aggregation Related to Amyloids: Methods of Investigation, Diversity, and Classification

(2018) Stanislav Bondarev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanistic and Structural Origins of the Asymmetric Barrier to Prion-like Cross-Seeding between Tau-3R and Tau-4R

(2018) Harish Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

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(2018)   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Nucleation and growth of a bacterial functional amyloid at single-fiber resolution

(2017) Mike Sleutel et al.   Nature Chemical Biology

Imaging Aβ(1–42) fibril elongation reveals strongly polarised growth and growth incompetent states

(2017) Laurence J. Young et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro

(2017) Ryo P. Honda et al.   Scientific Reports

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Physical determinants of the self-replication of protein fibrils

(2016) Anđela Šarić et al.   Nature Physics

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons

(2016) Dorothea Pinotsi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

(2016) Patrick Flagmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42aggregates

(2016) Takahiro Watanabe-Nakayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MpUL-multi: Software for Calculation of Amyloid Fibril Mass per Unit Length from TB-TEM Images

(2016) Matthew G. Iadanza et al.   Scientific Reports

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(2016)   CHEMBIOCHEM

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

(2016) James W. P. Brown et al.   Scientific Reports

Single Fibril Growth Kinetics of α-Synuclein

(2015) Michael M. Wördehoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

(2014) Alexander K. Buell et al.   Essays in Biochemistry

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

(2014) Kristoffer Brännström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry

(2014) T. Ikenoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast propagation of β-amyloid fibrils in oligomeric cloud

(2014) Hirotsugu Ogi et al.   Scientific Reports

An Imaging and Systems Modeling Approach to Fibril Breakage Enables Prediction of Amyloid Behavior

(2013) Wei-Feng Xue et al.   BIOPHYSICAL JOURNAL

Electrostatic Effects in Filamentous Protein Aggregation

(2013) Alexander K. Buell et al.   BIOPHYSICAL JOURNAL

β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation

(2013) Karunakar Kar et al.   JOURNAL OF MOLECULAR BIOLOGY

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

(2013) Tim Guilliams et al.   JOURNAL OF MOLECULAR BIOLOGY

Polymorph-Specific Kinetics and Thermodynamics of β-Amyloid Fibril Growth

(2013) Wei Qiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

(2013) Dorothea Pinotsi et al.   NANO LETTERS

Amyloid-Like Fibril Elongation Follows Michaelis-Menten Kinetics

(2013) Katazyna Milto et al.   PLoS One

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On-Surface Aggregation of α-Synuclein at Nanomolar Concentrations Results in Two Distinct Growth Mechanisms

(2012) Michael Rabe et al.   ACS Chemical Neuroscience

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

(2012) Alexander K. Buell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of Elongation and Secondary Pathways in S6 Amyloid Fibril Growth

(2012) Nikolai Lorenzen et al.   BIOPHYSICAL JOURNAL

Seed-Dependent Deposition Behavior of Aβ Peptides Studied with Wireless Quartz-Crystal-Microbalance Biosensor

(2011) Hirotsugu Ogi et al.   ANALYTICAL CHEMISTRY

Heterogeneous Amylin Fibril Growth Mechanisms Imaged by Total Internal Reflection Fluorescence Microscopy

(2011) Sharadrao M. Patil et al.   BIOCHEMISTRY

The Growth of Sickle Hemoglobin Polymers

(2011) Alexey Aprelev et al.   BIOPHYSICAL JOURNAL

Rapid Microtubule Self-Assembly Kinetics

(2011) Melissa K. Gardner et al.   CELL

Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments

(2011) Samuel I. A. Cohen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relationship between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly

(2011) Yi-Qian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation

(2011) Alexander K. Buell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Situ Measurements of the Formation and Morphology of Intracellular β-Amyloid Fibrils by Super-Resolution Fluorescence Imaging

(2011) Gabriele S. Kaminski Schierle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent

(2011) Karunakar Kar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer

(2011) Kristoffer Brännström et al.   PLoS One

A thermodynamic analysis of fibrillar polymorphism

(2010) Martin D. Jeppesen et al.   BIOPHYSICAL CHEMISTRY

The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

(2010) Christopher A. Waudby et al.   BIOPHYSICAL JOURNAL

Pre-Steady-State Kinetic Analysis of the Elongation of Amyloid Fibrils of β2-Microglobulin with Tryptophan Mutagenesis

(2010) Eri Chatani et al.   JOURNAL OF MOLECULAR BIOLOGY

Surface Attachment of Protein Fibrils via Covalent Modification Strategies

(2010) Alexander K. Buell et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein Aggregation in Crowded Environments

(2010) Duncan A. White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stop-and-go kinetics in amyloid fibrillation

(2010) Jesper Ferkinghoff-Borg et al.   PHYSICAL REVIEW E

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

(2010) Alexander K. Buell et al.   PHYSICAL REVIEW LETTERS

Deciphering the Structure, Growth and Assembly of Amyloid-Like Fibrils Using High-Speed Atomic Force Microscopy

(2010) Pierre-Emmanuel Milhiet et al.   PLoS One

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Branching in Amyloid Fibril Growth

(2009) Christian Beyschau Andersen et al.   BIOPHYSICAL JOURNAL

Energy barriers for HET-s prion forming domain amyloid formation

(2009) R. Sabaté et al.   FEBS Journal

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Quartz crystal microbalance analysis of growth kinetics for aggregation intermediates of the amyloid-β protein

(2008) Joseph A. Kotarek et al.   ANALYTICAL BIOCHEMISTRY

Thermal unfolding and aggregation of actin

(2008) Dmitrii I. Levitsky et al.   FEBS Journal

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology