Reprogramming of the epigenome in neurodevelopmental disorders

Phenotypic expansion of the BPTF ‐related neurodevelopmental disorder with dysmorphic facies and distal limb anomalies

(2021) Kevin E. Glinton et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders

(2020) Erfan Aref-Eshghi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1

(2020) Sabrina Oishi et al.   GENES BRAIN AND BEHAVIOR

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

(2020) Ana Rakita et al.   Scientific Reports

Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature

(2020) Andrea Ciolfi et al.   Clinical Epigenetics

Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer

(2020) Kezhi Yan et al.   Science Advances

A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome

(2020) Theodore G. Drivas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Wiedemann-steiner syndrome with a de novo mutation in KMT2A

(2020) Liu Jinxiu et al.   MEDICINE

Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome

(2020) Joost Kummeling et al.   MOLECULAR PSYCHIATRY

SETD1B-associated neurodevelopmental disorder

(2020) Alexandra Roston et al.   JOURNAL OF MEDICAL GENETICS

The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes

(2020) Sungryong Oh et al.   NUCLEIC ACIDS RESEARCH

The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

(2020) Jared V. Goodman et al.   Nature Communications

SETD5 Gene Haploinsufficiency in Three Patients With Suspected KBG Syndrome

(2020) Milena Crippa et al.   Frontiers in Neurology

EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways

(2020) Jiajia Wang et al.   Science Advances

De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy

(2020) Jonathan Humbert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas

(2020) Moritz Negwer et al.   Brain Structure & Function

Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects

(2020) Anna R. Duncan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients

(2020) Laura Bryant et al.   Science Advances

HDAC6 in Diseases of Cognition and of Neurons

(2020) Patrizia LoPresti   Cells

Broad neurodevelopmental features and cortical anomalies associated with a novel de novo KMT2A variant in Wiedemann−Steiner syndrome

(2020) Rosaria Nardello et al.   European Journal of Medical Genetics

Role for Chromatin Remodeling Factor Chd1 in Learning and Memory

(2019) Ines Schoberleitner et al.   Frontiers in Molecular Neuroscience

KDM4B: A Nail for Every Hammer?

(2019) Cailin Wilson et al.   Genes

Genotype–phenotype specificity in Menke–Hennekam syndrome caused by missense variants in exon 30 or 31 of CREBBP

(2019) Siddharth Banka et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Syndromic Neurodevelopmental Disorder Caused by Mutations in SMARCD1, a Core SWI/SNF Subunit Needed for Context-Dependent Neuronal Gene Regulation in Flies

(2019) Kevin C.J. Nixon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy

(2019) Anne H. O’Donnell-Luria et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel de novo frameshift variant in SETD1B causes epilepsy

(2019) Kouhei Den et al.   JOURNAL OF HUMAN GENETICS

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

(2019) Qianhua Xu et al.   NATURE GENETICS

Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis

(2019) Alexandra Mills et al.   Frontiers in Physiology

Mutations in SMARCB1 and in other Coffin–Siris syndrome genes lead to various brain midline defects

(2019) Alina Filatova et al.   Nature Communications

De Novo and Inherited SETD1A Variants in Early-onset Epilepsy

(2019) Xiuya Yu et al.   Neuroscience Bulletin

Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus

(2019) Pei-Pei Liu et al.   Stem Cell Reports

Chromatin Remodeling Complex NuRD in Neurodevelopment and Neurodevelopmental Disorders

(2019) Anke Hoffmann et al.   Frontiers in Genetics

Aberrant Function of the C-Terminal Tail of HIST1H1E Accelerates Cellular Senescence and Causes Premature Aging

(2019) Elisabetta Flex et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HIST1H1E heterozygous protein‐truncating variants cause a recognizable syndrome with intellectual disability and distinctive facial gestalt: A study to clarify the HIST1H1E syndrome phenotype in 30 individuals

(2019) Deepika D'Cunha Burkardt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

De novo truncating variant in NSD2gene leading to atypical Wolf-Hirschhorn syndrome phenotype

(2019) Yanrui Jiang et al.   BMC Medical Genetics

The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype–phenotype correlations, and molecular basis

(2019) Karin Weiss et al.   GENETICS IN MEDICINE

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

(2019) Daniel N. Weinberg et al.   NATURE

SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring

(2019) Alessandro Sessa et al.   NEURON

New insights into genetic variant spectrum and genotype–phenotype correlations of Rubinstein‐Taybi syndrome in 39 CREBBP‐ positive patients

(2019) Virginia Pérez‐Grijalba et al.   Molecular Genetics & Genomic Medicine

International meeting on Wolf‐Hirschhorn syndrome: Update on the nosology and new insights on the pathogenic mechanisms for seizures and growth delay

(2019) Julián Nevado et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

SETD2 related overgrowth syndrome: Presentation of four new patients and review of the literature

(2019) Pauline Marzin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Null variants and deletions in BRWD3 cause an X‐linked syndrome of mild–moderate intellectual disability, macrocephaly, and obesity: A series of 17 patients

(2019) Philip J. Ostrowski et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Update on KMT2B-Related Dystonia

(2019) Michael Zech et al.   Current Neurology and Neuroscience Reports

CHD2 ‐related epilepsy: novel mutations and new phenotypes

(2019) Jiaoyang Chen et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

(2019) Loredana Poeta et al.   HUMAN MOLECULAR GENETICS

Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling

(2019) Monica Frega et al.   Nature Communications

A genome-wide DNA methylation signature for SETD1B-related syndrome

(2019) I. M. Krzyzewska et al.   Clinical Epigenetics

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder

(2019) Federico Tessadori et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability

(2019) Lin Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in the BAF-Complex Subunit DPF2 Are Associated with Coffin-Siris Syndrome

(2018) Georgia Vasileiou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders

(2018) Víctor Faundes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome

(2018) Leonie A. Menke et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Growth pattern of Rahman syndrome

(2018) Toshiki Takenouchi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Epigenetics and autism spectrum disorder: A report of an autism case with mutation in H1 linker histone HIST1H1E and literature review

(2018) Lara J. Duffney et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Polycomb Protein Eed is Required for Neurogenesis and Cortical Injury Activation in the Subventricular Zone

(2018) Bin Sun et al.   CEREBRAL CORTEX

Novel SUZ12 mutations in Weaver-like syndrome

(2018) Eri Imagawa et al.   CLINICAL GENETICS

Genetic variations on SETD5 underlying autistic conditions

(2018) Isabella R. Fernandes et al.   Developmental Neurobiology

Targeted gene panel and genotype-phenotype correlation in children with developmental and epileptic encephalopathy

(2018) Ara Ko et al.   EPILEPSY RESEARCH

De novo truncating variants in WHSC1 recapitulate the Wolf–Hirschhorn (4p16.3 microdeletion) syndrome phenotype

(2018) Nada Derar et al.   GENETICS IN MEDICINE

De novo variants in SETD1B are associated with intellectual disability, epilepsy and autism

(2018) Takuya Hiraide et al.   HUMAN GENETICS

Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes

(2018) Aktan Alpsoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo nonsense mutation in WHSC1 (NSD2) in patient with intellectual disability and dysmorphic features

(2018) Ekaterina R. Lozier et al.   JOURNAL OF HUMAN GENETICS

Biochemical validation of EHMT1 missense mutations in Kleefstra syndrome

(2018) Ayumi Yamada et al.   JOURNAL OF HUMAN GENETICS

Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin

(2018) Chul-Hwan Lee et al.   MOLECULAR CELL

A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development

(2018) Else Eising et al.   MOLECULAR PSYCHIATRY

De novo variants in neurodevelopmental disorders with epilepsy

(2018) Henrike O. Heyne et al.   NATURE GENETICS

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phenotype variability and allelic heterogeneity in KMT2B -Associated disease

(2018) Toshitaka Kawarai et al.   PARKINSONISM & RELATED DISORDERS

The chromatin basis of neurodevelopmental disorders: Rethinking dysfunction along the molecular and temporal axes

(2018) Michele Gabriele et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

iPSC-derived neurons of CREBBP - and EP300 -mutated Rubinstein-Taybi syndrome patients show morphological alterations and hypoexcitability

(2018) Valentina Alari et al.   Stem Cell Research

Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

(2018) Xuemei Chen et al.   Nature Communications

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C

(2018) Laila C. Schenkel et al.   Clinical Epigenetics

UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling

(2018) Xuepei Lei et al.   Stem Cell Reports

Genetic testing in children and adolescents with intellectual disability

(2018) Nick Bass et al.   CURRENT OPINION IN PSYCHIATRY

KAT6A Syndrome: genotype–phenotype correlation in 76 patients with pathogenic KAT6A variants

(2018) Joanna Kennedy et al.   GENETICS IN MEDICINE

Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants

(2018) Lucilla Pizzo et al.   GENETICS IN MEDICINE

Expanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay

(2018) Keren Machol et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

(2018) Nazar Mashtalir et al.   CELL

The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin–Siris syndrome

(2018) Eline van der Sluijs et al.   GENETICS IN MEDICINE

Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition

(2018) Elena Deliu et al.   NATURE NEUROSCIENCE

Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory

(2018) Young J. Kim et al.   NEURON

Description of the molecular and phenotypic spectrum of Wiedemann-Steiner syndrome in Chinese patients

(2018) Niu Li et al.   Orphanet Journal of Rare Diseases

Quantifying the contribution of recessive coding variation to developmental disorders

(2018) Hilary C. Martin et al.   SCIENCE

CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

(2018) Lot Snijders Blok et al.   Nature Communications

Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome

(2018) Cheng Cheng et al.   Cell Reports

KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes

(2018) Giulia Barbagiovanni et al.   Cell Reports

SETD5 gene variant associated with mild intellectual disability - a case report

(2017) E. Stur et al.   GENETICS AND MOLECULAR RESEARCH

Mutations in chromatin regulators functionally link Cornelia de Lange syndrome and clinically overlapping phenotypes

(2017) Ilaria Parenti et al.   HUMAN GENETICS

Heterozygosity for ARID2 loss-of-function mutations in individuals with a Coffin–Siris syndrome-like phenotype

(2017) Nuria C. Bramswig et al.   HUMAN GENETICS

Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal

(2017) Gwenn-Aël Carré et al.   HUMAN MOLECULAR GENETICS

Heterozygous variants in ACTL6A , encoding a component of the BAF complex, are associated with intellectual disability

(2017) Ronit Marom et al.   HUMAN MUTATION

Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome

(2017) Eri Imagawa et al.   HUMAN MUTATION

Ezh2 Mutations Found in the Weaver Overgrowth Syndrome Cause a Partial Loss of H3K27 Histone Methyltransferase Activity

(2017) Julian C Lui et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability

(2017) Genay O Pilarowski et al.   JOURNAL OF MEDICAL GENETICS

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription

(2017) Shu-Ping Wang et al.   MOLECULAR CELL

KMT2B rare missense variants in generalized dystonia

(2017) Michael Zech et al.   MOVEMENT DISORDERS

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control

(2017) Federico Tessadori et al.   NATURE GENETICS

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

(2017) Holly A F Stessman et al.   NATURE GENETICS

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

(2017) Yuichiro Semba et al.   NUCLEIC ACIDS RESEARCH

H3K4 demethylase KDM5B regulates global dynamics of transcription elongation and alternative splicing in embryonic stem cells

(2017) Runsheng He et al.   NUCLEIC ACIDS RESEARCH

Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene

(2017) Rory T. Coleman et al.   SCIENCE

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

(2017) Ryan M. Walsh et al.   Nature Communications

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons

(2017) Marilyn Scandaglia et al.   Cell Reports

Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder

(2017) Tom S. Koemans et al.   PLoS Genetics

Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment

(2017) Cemre Celen et al.   eLife

Haploinsufficiency of KMT2B , Encoding the Lysine-Specific Histone Methyltransferase 2B, Results in Early-Onset Generalized Dystonia

(2016) Michael Zech et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Systematic Phenomics Analysis Deconvolutes Genes Mutated in Intellectual Disability into Biologically Coherent Modules

(2016) Korinna Kochinke et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Further delineation of the phenotype of truncatingKMT2Amutations: The extended Wiedemann-Steiner syndrome

(2016) Yu Sun et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Congenital immunodeficiency in an individual with Wiedemann-Steiner syndrome due to a novel missense mutation inKMT2A

(2016) Emilia Stellacci et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

CREBBPmutations in individuals without Rubinstein-Taybi syndrome phenotype

(2016) Leonie A. Menke et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

NovelEEDmutation in patient with Weaver syndrome

(2016) Erin Cooney et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Complex phenotypes blur conventional borders between Say-Barber-Biesecker-Young-Simpson syndrome and genitopatellar syndrome

(2016) J. Radvanszky et al.   CLINICAL GENETICS

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

(2016) Ana S.A. Cohen et al.   HUMAN MUTATION

EED-associated overgrowth in a second male patient

(2016) Ana SA Cohen et al.   JOURNAL OF HUMAN GENETICS

Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells

(2016) Gengze Wei et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice

(2016) Qiong Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

(2016) Alejandro Sifrim et al.   NATURE GENETICS

Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia

(2016) Esther Meyer et al.   NATURE GENETICS

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

(2016) Tarjinder Singh et al.   NATURE NEUROSCIENCE

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

De novo genic mutations among a Chinese autism spectrum disorder cohort

(2016) Tianyun Wang et al.   Nature Communications

Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α

(2016) Τao Zhu et al.   Scientific Reports

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

(2016) Shigeki Iwase et al.   Cell Reports

Dominant Mutations in KAT6A Cause Intellectual Disability with Recognizable Syndromic Features

(2015) Emma Tham et al.   AMERICAN JOURNAL OF HUMAN GENETICS

De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay

(2015) Valerie A. Arboleda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling

(2015) Georgia Vasileiou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice1

(2015) Michelle L. Brinkmeier et al.   BIOLOGY OF REPRODUCTION

Delineation of clinical features in Wiedemann-Steiner syndrome caused by KMT2A mutations

(2015) N. Miyake et al.   CLINICAL GENETICS

HDAC8-deficiency causes an X-linked dominant disorder with a wide range of severity

(2015) D. A. Mordaunt et al.   CLINICAL GENETICS

Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3

(2015) W.-Y. Chen et al.   EMBO REPORTS

The Koolen-de Vries syndrome: a phenotypic comparison of patients with a 17q21.31 microdeletion versus a KANSL1 sequence variant

(2015) David A Koolen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A patient showing features of both SBBYSS and GPS supports the concept of a KAT6B-related disease spectrum, with mutations in mid-exon 18 possibly leading to combined phenotypes

(2015) Marketa Vlckova et al.   European Journal of Medical Genetics

Gene discovery for Mendelian conditions via social networking: de novo variants in KDM1A cause developmental delay and distinctive facial features

(2015) Jessica X. Chong et al.   GENETICS IN MEDICINE

The Mendelian disorders of the epigenetic machinery

(2015) Hans Tomas Bjornsson   GENOME RESEARCH

Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity

(2015) Emily Brookes et al.   HUMAN MOLECULAR GENETICS

Kabuki syndrome genesKMT2DandKDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development

(2015) Peter M. Van Laarhoven et al.   HUMAN MOLECULAR GENETICS

Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease

(2015) Yunhui Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deficiency of the Chromatin Regulator Brpf1 Causes Abnormal Brain Development

(2015) Linya You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global transcriptional disturbances underlie Cornelia de Lange syndrome and related phenotypes

(2015) Bo Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression

(2015) Y. Ma et al.   JOURNAL OF NEUROSCIENCE

Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory

(2015) M. Jakovcevski et al.   JOURNAL OF NEUROSCIENCE

Excess of rare, inherited truncating mutations in autism

(2015) Niklas Krumm et al.   NATURE GENETICS

Mutations in ARID2 are associated with intellectual disabilities

(2015) Linshan Shang et al.   NEUROGENETICS

Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex

(2015) Linnan Zhao et al.   Scientific Reports

The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

(2015) Linya You et al.   PLoS Genetics

Wolf-Hirschhorn Syndrome (WHS) – Literature Review on the Features of the Syndrome

(2015) Anna Paradowska-Stolarz   Advances in Clinical and Experimental Medicine

De Novo Loss-of-Function Mutations in SETD5, Encoding a Methyltransferase in a 3p25 Microdeletion Syndrome Critical Region, Cause Intellectual Disability

(2014) Detelina Grozeva et al.   AMERICAN JOURNAL OF HUMAN GENETICS

De novoANKRD11andKDM1Agene mutations in a male with features of KBG syndrome and Kabuki syndrome

(2014) Sanjin Tunovic et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Haploinsufficiency of HDAC4 does not cause intellectual disability in all affected individuals

(2014) Patricia G. Wheeler et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Microdeletion of 12q24.31: Report of a girl with intellectual disability, stereotypies, seizures and facial dysmorphisms

(2014) Orazio Palumbo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Phenotype and genotype in Nicolaides-Baraitser syndrome

(2014) Sérgio B. Sousa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations inSMARCB1,SMARCA4,SMARCE1, andARID1A

(2014) Tomoki Kosho et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Nucleosome Structure and Function

(2014) Robert K. McGinty et al.   CHEMICAL REVIEWS

Neural Crest Development and Craniofacial Morphogenesis Is Coordinated by Nitric Oxide and Histone Acetylation

(2014) Yawei Kong et al.   CHEMISTRY & BIOLOGY

Cornelia de Lange syndrome

(2014) M.I. Boyle et al.   CLINICAL GENETICS

Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast

(2014) M. Guzman-Ayala et al.   DEVELOPMENT

Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome

(2014) Alma Kuechler et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance

(2014) Yvonne Schulz et al.   HUMAN GENETICS

Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance

(2014) Frank J. Kaiser et al.   HUMAN MOLECULAR GENETICS

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development

(2014) Gen-Bao Shao et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Mutations inSETD2cause a novel overgrowth condition

(2014) Armelle Luscan et al.   JOURNAL OF MEDICAL GENETICS

A Role for H3K4 Monomethylation in Gene Repression and Partitioning of Chromatin Readers

(2014) Jemmie Cheng et al.   MOLECULAR CELL

The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing

(2014) Chiara Mozzetta et al.   MOLECULAR CELL

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Large-scale discovery of novel genetic causes of developmental disorders

(2014) T. W. Fitzgerald et al.   NATURE

Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

(2014) Tomoko Yamada et al.   NEURON

The genetics of cognitive epigenetics

(2014) Tjitske Kleefstra et al.   NEUROPHARMACOLOGY

Comprehensive Evaluation of the Child With Intellectual Disability or Global Developmental Delays

(2014) J. B. Moeschler et al.   PEDIATRICS

Histone H3 Lysine 36 Methyltransferase Whsc1 Promotes the Association of Runx2 and p300 in the Activation of Bone-Related Genes

(2014) Yu Fei Lee et al.   PLoS One

Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units

(2014) F. Song et al.   SCIENCE

CHD7 Maintains Neural Stem Cell Quiescence and Prevents Premature Stem Cell Depletion in the Adult Hippocampus

(2014) Kieran M. Jones et al.   STEM CELLS

Writers and Readers of Histone Acetylation: Structure, Mechanism, and Inhibition

(2014) R. Marmorstein et al.   Cold Spring Harbor Perspectives in Biology

Activation of Neuronal Gene Expression by the JMJD3 Demethylase Is Required for Postnatal and Adult Brain Neurogenesis

(2014) Dae Hwi Park et al.   Cell Reports

De Novo Loss-of-Function Mutations in CHD2 Cause a Fever-Sensitive Myoclonic Epileptic Encephalopathy Sharing Features with Dravet Syndrome

(2013) Arvid Suls et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C

(2013) Daria Grafodatskaya et al.   BMC Medical Genomics

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation

(2013) Yang Yu et al.   CELL

CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development

(2013) David Tsui et al.   DEVELOPMENTAL BIOLOGY

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

CHD7 and retinoic acid signaling cooperate to regulate neural stem cell and inner ear development in mouse models of CHARGE syndrome

(2013) Joseph A. Micucci et al.   HUMAN MOLECULAR GENETICS

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

(2013) D. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation

(2013) Fade Gong et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1

(2013) Gemma L Carvill et al.   NATURE GENETICS

The X-Linked Intellectual Disability Protein PHF6 Associates with the PAF1 Complex and Regulates Neuronal Migration in the Mammalian Brain

(2013) Chi Zhang et al.   NEURON

Diagnostic Exome Sequencing in Persons With Severe Intellectual Disability

(2013) Joep de Ligt et al.   OBSTETRICAL & GYNECOLOGICAL SURVEY

An epigenetic signature of developmental potential in neural stem cells and early neurons

(2013) Matthew J. Burney et al.   STEM CELLS

The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3

(2013) Mareike Albert et al.   PLoS Genetics

Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets

(2013) Giulia Fragola et al.   PLoS Genetics

USF1 and hSET1A Mediated Epigenetic Modifications Regulate Lineage Differentiation and HoxB4 Transcription

(2013) Changwang Deng et al.   PLoS Genetics

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

(2013) Ji-Eun Lee et al.   eLife

De Novo Mutations in MLL Cause Wiedemann-Steiner Syndrome

(2012) Wendy D. Jones et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disruption of an EHMT1-Associated Chromatin-Modification Module Causes Intellectual Disability

(2012) Tjitske Kleefstra et al.   AMERICAN JOURNAL OF HUMAN GENETICS

De Novo Mutations of the Gene Encoding the Histone Acetyltransferase KAT6B Cause Genitopatellar Syndrome

(2012) Michael A. Simpson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions

(2012) Hector Rincon-Arano et al.   CELL

MLL2mosaic mutations and intragenic deletion-duplications in patients with Kabuki syndrome

(2012) S Banka et al.   CLINICAL GENETICS

Unmasking Kabuki syndrome

(2012) N Bögershausen et al.   CLINICAL GENETICS

Chromatin-Remodeling Factor Brg1 Is Required for Schwann Cell Differentiation and Myelination

(2012) Matthias Weider et al.   DEVELOPMENTAL CELL

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome

(2012) Anne K. Voss et al.   DEVELOPMENTAL CELL

Phenotypic variant of Brachydactyly-mental retardation syndrome in a family with an inherited interstitial 2q37.3 microdeletion including HDAC4

(2012) Pablo Villavicencio-Lorini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

(2012) S. S. Dhar et al.   GENES & DEVELOPMENT

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4

(2012) H.-M. Herz et al.   GENES & DEVELOPMENT

Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome

(2012) M. C. M. Balemans et al.   HUMAN MOLECULAR GENETICS

KDM6A Point Mutations Cause Kabuki Syndrome

(2012) Noriko Miyake et al.   HUMAN MUTATION

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

(2012) M.-S. Kim et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex

(2012) Janine B. Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study

(2012) Anita Rauch et al.   LANCET

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

Mutations in SWI/SNF chromatin remodeling complex gene ARID1B cause Coffin-Siris syndrome

(2012) Gijs W E Santen et al.   NATURE GENETICS

Mutations in KANSL1 cause the 17q21.31 microdeletion syndrome phenotype

(2012) Marcella Zollino et al.   NATURE GENETICS

Mutations in the chromatin modifier gene KANSL1 cause the 17q21.31 microdeletion syndrome

(2012) David A Koolen et al.   NATURE GENETICS

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

(2012) Constantin d'Ydewalle et al.   TRAFFIC

Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome

(2011) Jill Clayton-Smith et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in EZH2 Cause Weaver Syndrome

(2011) William T. Gibson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome

(2011) Damien Lederer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome

(2011) Mark C. Hannibal et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

How genetically heterogeneous is Kabuki syndrome?: MLL2 testing in 116 patients, review and analyses of mutation and phenotypic spectrum

(2011) Siddharth Banka et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Deletion of the RMGA and CHD2 genes in a child with epilepsy and mental deficiency

(2011) Leonardo P. Capelli et al.   European Journal of Medical Genetics

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities

(2011) Erin B. Kaminsky et al.   GENETICS IN MEDICINE

The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation

(2011) Qi Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of CBP in Forebrain Principal Neurons Causes Modest Memory and Transcriptional Defects and a Dramatic Reduction of Histone Acetylation But Does Not Affect Cell Viability

(2011) L. M. Valor et al.   JOURNAL OF NEUROSCIENCE

HAT4, a Golgi Apparatus-Anchored B-Type Histone Acetyltransferase, Acetylates Free Histone H4 and Facilitates Chromatin Assembly

(2011) Xiaohan Yang et al.   MOLECULAR CELL

Mutation spectrum of MLL2 in a cohort of kabuki syndrome patients

(2011) Lucia Micale et al.   Orphanet Journal of Rare Diseases

Microdeletion of Chromosome 15q26.1 in a Child With Intractable Generalized Epilepsy

(2011) Radhika Dhamija et al.   PEDIATRIC NEUROLOGY

Trends in the Prevalence of Developmental Disabilities in US Children, 1997-2008

(2011) C. A. Boyle et al.   PEDIATRICS

Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems

(2010) Stephen R. Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Wiedemann-Steiner syndrome: Three further cases

(2010) Rainer Koenig et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Functional characterization of the zebrafish WHSC1-related gene, a homolog of human NSD2

(2010) Toshiko Yamada-Okabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear

(2010) E. A. Hurd et al.   DEVELOPMENT

CBP Histone Acetyltransferase Activity Regulates Embryonic Neural Differentiation in the Normal and Rubinstein-Taybi Syndrome Brain

(2010) Jing Wang et al.   DEVELOPMENTAL CELL

A mutation in the 3′-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia

(2010) Delphine Simon et al.   HUMAN MOLECULAR GENETICS

MLL2 mutation spectrum in 45 patients with Kabuki syndrome

(2010) Aimée D. C. Paulussen et al.   HUMAN MUTATION

NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome

(2010) Martina P. Pasillas et al.   HUMAN MUTATION

The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila

(2010) M. Lone et al.   JOURNAL OF CELL SCIENCE

Alternative Splicing of the Histone Demethylase LSD1/KDM1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System

(2010) C. Zibetti et al.   JOURNAL OF NEUROSCIENCE

The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila

(2010) Sunil Jayaramaiah Raja et al.   MOLECULAR CELL

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

(2010) Hank H. Qi et al.   NATURE

CHD7 cooperates with PBAF to control multipotent neural crest formation

(2010) Ruchi Bajpai et al.   NATURE

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

(2010) Sarah B Ng et al.   NATURE GENETICS

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

(2010) Weijun Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling

(2010) M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

(2010) A. K. Lucio-Eterovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two patients with EP300 mutations and facial dysmorphism different from the classic Rubinstein-Taybi syndrome

(2009) Oliver Bartsch et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Dimethylation of H3K4 by Set1 Recruits the Set3 Histone Deacetylase Complex to 5′ Transcribed Regions

(2009) TaeSoo Kim et al.   CELL

Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity

(2009) Anne K. Voss et al.   DEVELOPMENTAL CELL

Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube

(2009) X. Miro et al.   Disease Models & Mechanisms

Early onset myoclonic epilepsy and 15q26 microdeletion: Observation of the first case

(2009) Chiara Veredice et al.   EPILEPSIA

Epigenetic control of skull morphogenesis by histone deacetylase 8

(2009) M. Haberland et al.   GENES & DEVELOPMENT

Subunit Composition and Substrate Specificity of a MOF-containing Histone Acetyltransferase Distinct from the Male-specific Lethal (MSL) Complex

(2009) Yong Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype

(2009) T Kleefstra et al.   JOURNAL OF MEDICAL GENETICS

Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes

(2009) M. Ullah et al.   MOLECULAR AND CELLULAR BIOLOGY

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

Two Mammalian MOF Complexes Regulate Transcription Activation by Distinct Mechanisms

(2009) Xiangzhi Li et al.   MOLECULAR CELL

Crucial Roles for Interactions between MLL3/4 and INI1 in Nuclear Receptor Transactivation

(2009) Seunghee Lee et al.   MOLECULAR ENDOCRINOLOGY

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

(2009) Daniel A. Lim et al.   NATURE

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

(2009) Keisuke Nimura et al.   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein–Taybi syndrome etiology

(2009) Jose Viosca et al.   NEUROBIOLOGY OF DISEASE

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation

(2009) S. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment

(2008) Thomas Burgold et al.   PLoS One