Full‐Atom Model of the Agonist LPS‐Bound Toll‐like Receptor 4 Dimer in a Membrane Environment
出版年份 2021 全文链接
标题
Full‐Atom Model of the Agonist LPS‐Bound Toll‐like Receptor 4 Dimer in a Membrane Environment
作者
关键词
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出版物
CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 62, Pages 15406-15425
出版商
Wiley
发表日期
2021-09-27
DOI
10.1002/chem.202102995
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches
- (2020) Qurat ul Ain et al. MOLECULES
- Computational Modeling of Realistic Cell Membranes
- (2019) Siewert J. Marrink et al. CHEMICAL REVIEWS
- Multiscale modeling of innate immune receptors: Endotoxin recognition and regulation by host defense peptides
- (2019) Daniel A. Holdbrook et al. PHARMACOLOGICAL RESEARCH
- The energetics of protein–lipid interactions as viewed by molecular simulations
- (2019) Robin A. Corey et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives
- (2018) Lenny Zaffaroni et al. Future Medicinal Chemistry
- A Thermodynamic Funnel Drives Bacterial Lipopolysaccharide Transfer in the TLR4 Pathway
- (2018) Roland G. Huber et al. STRUCTURE
- Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub
- (2018) Sarah Louise Latty et al. eLife
- Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer
- (2018) Mahesh Chandra Patra et al. Frontiers in Immunology
- TLR4-based immunotherapeutics in cancer: a review of the achievements and shortcomings
- (2018) Maryam A. Shetab Boushehri et al. MOLECULAR PHARMACEUTICS
- Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico
- (2018) Edouard Mobarak et al. Scientific Reports
- UniProt: a worldwide hub of protein knowledge
- (2018) NUCLEIC ACIDS RESEARCH
- Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
- (2018) Gustavo P. Amarante-Mendes et al. Frontiers in Immunology
- Trial Watch: Toll-like receptor agonists in cancer immunotherapy
- (2018) Melody Smith et al. OncoImmunology
- Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals
- (2017) Mallenahally Kusha Vidya et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling
- (2017) Stefania E. Sestito et al. JOURNAL OF MEDICINAL CHEMISTRY
- TMDOCK: An Energy-Based Method for Modeling α-Helical Dimers in Membranes
- (2017) Andrei L. Lomize et al. JOURNAL OF MOLECULAR BIOLOGY
- Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
- (2017) Thomas Ve et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
- (2017) Thomas Ve et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism
- (2017) Konstantin S. Mineev et al. Scientific Reports
- Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties
- (2016) Carlotta Ciaramelli et al. Chemical Biology & Drug Design
- Small-Molecule Carbohydrate-Based Immunostimulants
- (2016) Cecilia H. Marzabadi et al. CHEMISTRY-A EUROPEAN JOURNAL
- Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135in Transfer of Lipopolysaccharide from CD14 to MD-2
- (2016) Jožica Vašl et al. JOURNAL OF IMMUNOLOGY
- The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations
- (2016) Antreas C. Kalli et al. JOURNAL OF MEMBRANE BIOLOGY
- Computational Approaches to Toll-Like Receptor 4 Modulation
- (2016) Jean-Marc Billod et al. MOLECULES
- Role of lipid microdomains in TLR-mediated signalling
- (2015) Jean-Marie Ruysschaert et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Mechanical properties of lipid bilayers from molecular dynamics simulation
- (2015) Richard M. Venable et al. CHEMISTRY AND PHYSICS OF LIPIDS
- Modulation of Toll-Like Receptor 4. Insights from X-Ray Crystallography and Molecular Modeling
- (2015) Javier Klett et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate ofBurkholderia cenocepacia
- (2015) Flaviana Di Lorenzo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins
- (2015) Edward Harder et al. Journal of Chemical Theory and Computation
- ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
- (2015) James A. Maier et al. Journal of Chemical Theory and Computation
- Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains
- (2014) Thomas Ve et al. APOPTOSIS
- Assessing the local structural quality of transmembrane protein models using statistical potentials (QMEANBrane)
- (2014) Gabriel Studer et al. BIOINFORMATICS
- Chemistry of Lipid A: At the Heart of Innate Immunity
- (2014) Antonio Molinaro et al. CHEMISTRY-A EUROPEAN JOURNAL
- Lipid14: The Amber Lipid Force Field
- (2014) Callum J. Dickson et al. Journal of Chemical Theory and Computation
- CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations
- (2014) Emilia L. Wu et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Toll-Like Receptor Signaling Pathways
- (2014) Takumi Kawasaki et al. Frontiers in Immunology
- PREDDIMER: a web server for prediction of transmembrane helical dimers
- (2013) Anton A. Polyansky et al. BIOINFORMATICS
- Architecture and Membrane Interactions of the EGF Receptor
- (2013) Anton Arkhipov et al. CELL
- Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis
- (2013) Steven M. Opal et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Structural Basis for Endotoxin-induced Allosteric Regulation of the Toll-like Receptor 4 (TLR4) Innate Immune Receptor
- (2013) Teresa Paramo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Binding Sites for Myeloid Differentiation Primary Response Gene 88 (MyD88) and Toll-like Receptor 4 in MyD88 Adapter-like (Mal)
- (2013) Celia Bovijn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective
- (2013) Ishwarlal Jialal et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
- (2013) G. Madhavi Sastry et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets
- (2012) Thomas Ve et al. CURRENT DRUG TARGETS
- Isolated Toll-like Receptor Transmembrane Domains Are Capable of Oligomerization
- (2012) James I. Godfroy et al. PLoS One
- Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
- (2012) U. Ohto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4
- (2011) Celia Bovijn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Ectodomain of the Toll-like Receptor 4 Prevents Constitutive Receptor Activation
- (2011) Gabriela Panter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface
- (2011) V. Y. Toshchakov et al. JOURNAL OF IMMUNOLOGY
- Different functional role of domain boundaries of Toll-like receptor 4
- (2009) Mireille Treeby et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin
- (2009) Nuša Resman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
- (2009) Beom Seok Park et al. NATURE
- The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer
- (2008) Tomas Nyman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane lipids: where they are and how they behave
- (2008) Gerrit van Meer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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