Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives

Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216

(2017) Motofumi Kumazoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developments of Anticoagulants and New Agents with Anti-Coagulant Effects in Deep Vein Thrombosis

(2017) Yi-Ping Dang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Therapeutic implications of toll-like receptors in peripheral neuropathic pain

(2017) Krishan K. Thakur et al.   PHARMACOLOGICAL RESEARCH

TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells and protects mice from lethal influenza infection

(2017) Laure Perrin-Cocon et al.   Scientific Reports

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis

(2017) Sally E. Dickinson et al.   CURRENT MEDICINAL CHEMISTRY

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exploring the Binding Proteins of Glycolipids with Bifunctional Chemical Probes

(2016) Xiaohui Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

(2016) Erin E. Mulvihill et al.   Annual Review of Nutrition

Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4

(2016) Vincent A. van der Mark et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chemical Hybridization of Vizantin and Lipid A to Generate a Novel LPS Antagonist

(2016) Hirofumi Yamamoto et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS

(2016) E Monnet et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013–14

(2016) Nirav S. Shah et al.   JOURNAL OF CLINICAL VIROLOGY

Structural analogs of pulmonary surfactant phosphatidylglycerol inhibit toll-like receptor 2 and 4 signaling

(2016) Pitchaimani Kandasamy et al.   JOURNAL OF LIPID RESEARCH

Discovery and Structure–Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

(2016) Matthew D. Morin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computational Approaches to Toll-Like Receptor 4 Modulation

(2016) Jean-Marc Billod et al.   MOLECULES

Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model

(2016) Massimiliano De Paola et al.   PHARMACOLOGICAL RESEARCH

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation

(2016) Jason D. Marshall et al.   PLoS One

Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury

(2016) Yali Zhang et al.   Scientific Reports

Invasive Aspergillosis Associated With Severe Influenza Infections

(2016) Nancy F. Crum-Cianflone   Open Forum Infectious Diseases

Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis

(2016) Xuexiu He et al.   Scientific Reports

Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling

(2016) Raquel Rodrigues-Diez et al.   Scientific Reports

The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway

(2016) Xin Liu et al.   Scientific Reports

A structural insight into the negative effects of opioids in analgesia by modulating the TLR4 signaling: An in silico approach

(2016) Masaud Shah et al.   Scientific Reports

Mannoside Glycolipid Conjugates Display Anti-inflammatory Activity by Inhibition of Toll-like Receptor-4 Mediated Cell Activation

(2015) Vincent Flacher et al.   ACS Chemical Biology

Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation

(2015) Jing Li et al.   ChemMedChem

Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4

(2015) Ryan Bachtell et al.   CNS & Neurological Disorders-Drug Targets

Postulates for validating TLR4 agonists

(2015) Mateja Manček-Keber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Anticancer effect of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways

(2015) Shweta Shrivastava et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Structure–Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists

(2015) Brandon R. Selfridge et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Sustained immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine administered as a two-dose schedule in adolescent girls: Five-year clinical data and modeling predictions from a randomized study

(2015) Barbara Romanowski et al.   Human Vaccines & Immunotherapeutics

MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4

(2015) Alja Oblak et al.   PLoS One

Chemistry of Lipid A: At the Heart of Innate Immunity

(2014) Antonio Molinaro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Role of Ferulic Acid in the Amelioration of Ionizing Radiation Induced Inflammation: A Murine Model

(2014) Ujjal Das et al.   PLoS One

Modulation of CD14 and TLR4⋅MD-2 Activities by a Synthetic Lipid A Mimetic

(2013) Roberto Cighetti et al.   CHEMBIOCHEM

P4 ATPases: Flippases in Health and Disease

(2013) Vincent van der Mark et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update

(2013) Francesco Peri et al.   JOURNAL OF MEDICINAL CHEMISTRY

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

(2013) Tasha E Fingerlin et al.   NATURE GENETICS

P4-ATPases: lipid flippases in cell membranes

(2013) Rosa L. Lopez-Marques et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

(2012) Badrinarayanan Raghavan et al.   EMBO REPORTS

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist

(2012) W. S. Bowen et al.   Science Signaling

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

(2012) Richa Hanamsagar et al.   TRENDS IN IMMUNOLOGY

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

Intrinsic and Extrinsic Regulation of Innate Immune Receptors

(2011) Eunshil Jeong et al.   YONSEI MEDICAL JOURNAL

Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway

(2011) Valentina Ulivi et al.   ARTHRITIS RESEARCH & THERAPY

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Differences in presentation and progression between severe FIC1 and BSEP deficiencies

(2010) Ludmila Pawlikowska et al.   JOURNAL OF HEPATOLOGY

Xanthohumol and Related Prenylated Flavonoids Inhibit Inflammatory Cytokine Production in LPS-Activated THP-1 Monocytes: Structure-Activity Relationships andIn SilicoBinding to Myeloid Differentiation Protein-2 (MD-2)

(2010) Michael Peluso et al.   PLANTA MEDICA

Effector and regulatory mechanisms in allergic contact dermatitis

(2009) M. Vocanson et al.   ALLERGY

Significant Reduction In Combined Symptom And Medication Score Compared With Placebo Following MPL-Adjuvanted uSCIT In Patients With Seasonal Grass Pollen Allergy

(2009) L.M. DuBuske et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-interacting Proteins CD14 and MD-2

(2009) Koji Kuronuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition

(2008) Ji Won Chung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA