Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties

Molecular simplification of lipid A structure: TLR4-modulating cationic and anionic amphiphiles

(2015) Valentina Calabrese et al.   MOLECULAR IMMUNOLOGY

Chemistry of Lipid A: At the Heart of Innate Immunity

(2014) Antonio Molinaro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators

(2014) Julio Rodriguez Lavado et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of CD14 and TLR4⋅MD-2 Activities by a Synthetic Lipid A Mimetic

(2013) Roberto Cighetti et al.   CHEMBIOCHEM

Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update

(2013) Francesco Peri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cationic lipids activate intracellular signaling pathways

(2012) Caroline Lonez et al.   ADVANCED DRUG DELIVERY REVIEWS

A Synthetic Lipid A Mimetic Modulates Human TLR4 Activity

(2011) Matteo Piazza et al.   ChemMedChem

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding

(2010) Matteo Piazza et al.   BIOCHEMICAL PHARMACOLOGY

Hyperbranched Polyglycerol-Based Lipids via Oxyanionic Polymerization: Toward Multifunctional Stealth Liposomes

(2010) Anna Maria Hofmann et al.   BIOMACROMOLECULES

Evidence of a Specific Interaction between New Synthetic Antisepsis Agents and CD14

(2009) Matteo Piazza et al.   BIOCHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Glycolipids and Benzylammonium Lipids as Novel Antisepsis Agents: Synthesis and Biological Characterization

(2009) Matteo Piazza et al.   JOURNAL OF MEDICINAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain

(2008) L. Cao et al.   NEUROSCIENCE