Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals

TLR-7 agonist attenuates airway reactivity and inflammation through Nrf2-mediated antioxidant protection in a murine model of allergic asthma

(2016) Ahmed Nadeem et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Quantitative expression of hepatic toll-like receptors 1–10 mRNA in Osmanabadi goats during different climatic stresses

(2016) I. Sophia et al.   SMALL RUMINANT RESEARCH

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis

(2014) S. C. Gribar et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection

(2014) Ejuan Zhang et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Development of a mouse model mimicking key aspects of a viral asthma exacerbation

(2013) Deborah L. Clarke et al.   CLINICAL SCIENCE

Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells

(2013) Naveen Sharma et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation

(2012) T. V. Brennan et al.   BLOOD

Age and low levels of circulating vitamin D are associated with impaired innate immune function

(2012) Lorena Alvarez-Rodriguez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extracellular Heat Shock Protein 70 Induces Cardiomyocyte Inflammation and Contractile Dysfunction via TLR2

(2011) Sumeet Mathur et al.   CIRCULATION JOURNAL

Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1

(2011) Jianzhong Zhu et al.   EXPERIMENTAL PARASITOLOGY

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes

(2009) Giuseppe M. Campo et al.   BIOCHIMIE

Toll-Like Receptor-2 Mediates Inflammation and Matrix Degradation in Human Atherosclerosis

(2009) Claudia Monaco et al.   CIRCULATION

Estrogens Augment Cell Surface TLR4 Expression on Murine Macrophages and Regulate Sepsis Susceptibilityin Vivo

(2009) Jennifer A. Rettew et al.   ENDOCRINOLOGY

Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor

(2009) So Young Kim et al.   IMMUNOLOGY

Fibrinogen That Appears in Bowman’s Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-Like Receptors 2 and 4 in vitro

(2009) Masaru Motojima et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart

(2008) Wei Chao   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance

(2008) Oliver C Jann et al.   BMC EVOLUTIONARY BIOLOGY

Toll-like receptors expressed in tumor cells: targets for therapy

(2008) Li Yu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

(2008) M. R. Dasu et al.   DIABETES

Candida albicansphospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2

(2008) Min Li et al.   EXPERIMENTAL DERMATOLOGY

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

(2008) Istvan Hritz et al.   HEPATOLOGY

Glucocorticoids Inhibit IRF3 Phosphorylation in Response to Toll-like Receptor-3 and -4 by Targeting TBK1 Activation

(2008) Claire E. McCoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION

Increased Toll-Like Receptor (TLR) 2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Proinflammatory State

(2007) Sridevi Devaraj et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM