Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis

Phase Separation during Germline Development

(2021) Chun So et al.   TRENDS IN CELL BIOLOGY

Loop extrusion as a mechanism for formation of DNA damage repair foci

(2021) Coline Arnould et al.   NATURE

The male germline-specific protein MAPS is indispensable for pachynema progression and fertility

(2021) Miao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-driven condensation assembles the meiotic DNA break machinery

(2021) Corentin Claeys Bouuaert et al.   NATURE

FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation

(2021) Lan Xu et al.   Cell Death & Disease

A Hypothesis: Linking Phase Separation to Meiotic Sex Chromosome Inactivation and Sex-Body Formation

(2021) Yiding Xu et al.   Frontiers in Cell and Developmental Biology

The XY body: an attractive chromatin domain

(2020) Mary Ann Handel   BIOLOGY OF REPRODUCTION

The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis

(2020) Hironori Abe et al.   CURRENT BIOLOGY

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

(2020) Yan G. Zhao et al.   DEVELOPMENTAL CELL

ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling

(2020) Catalina Pereira et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Phase Separation in Germ Cells and Development

(2020) Anne E. Dodson et al.   DEVELOPMENTAL CELL

Endogenous retroviruses drive species-specific germline transcriptomes in mammals

(2020) Akihiko Sakashita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition

(2020) So Maezawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual functions for the ssDNA-binding protein RPA in meiotic recombination

(2019) Baolu Shi et al.   PLoS Genetics

The Fanconi Anemia Pathway and Fertility

(2019) Vanessa Tsui et al.   TRENDS IN GENETICS

Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development

(2019) Kris G. Alavattam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase

(2019) Lucas Patel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis

(2019) Yao Wang et al.   MOLECULAR CELL

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Phase separation drives X-chromosome inactivation: a hypothesis

(2019) Andrea Cerase et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

(2019) David Trombley McSwiggen et al.   eLife

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

The nucleolus functions as a phase-separated protein quality control compartment

(2019) F. Frottin et al.   SCIENCE

Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis

(2019) Covadonga Vara et al.   Cell Reports

DNA damage kinase signaling: checkpoint and repair at 30 years

(2019) Michael Charles Lanz et al.   EMBO JOURNAL

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

(2019) David T. McSwiggen et al.   GENES & DEVELOPMENT

Principles of meiotic chromosome assembly revealed in S. cerevisiae

(2019) Stephanie A. Schalbetter et al.   Nature Communications

Probing and engineering liquid-phase organelles

(2019) Dan Bracha et al.   NATURE BIOTECHNOLOGY

Meiosis: the chromosomal foundation of reproduction

(2018) Ewelina Bolcun-Filas et al.   BIOLOGY OF REPRODUCTION

SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X

(2018) Chen-Yu Wang et al.   CELL

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Organization and Function of Non-dynamic Biomolecular Condensates

(2018) Jeffrey B. Woodruff et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

ATR is a multifunctional regulator of male mouse meiosis

(2018) Alexander Widger et al.   Nature Communications

ATR is required to complete meiotic recombination in mice

(2018) Sarai Pacheco et al.   Nature Communications

RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes

(2018) Shannel R. Adams et al.   PLoS Genetics

A rapidly evolved domain, the SCML2 DNA-binding (SDB) repeats, contributes to chromatin binding of mouse SCML2

(2018) So Maezawa et al.   BIOLOGY OF REPRODUCTION

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice

(2018) Takayuki Hirota et al.   DEVELOPMENTAL CELL

The cohesin complex in mammalian meiosis

(2018) Kei-ichiro Ishiguro   GENES TO CELLS

Organizational principles of 3D genome architecture

(2018) M. Jordan Rowley et al.   NATURE REVIEWS GENETICS

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

(2018) Demis Menolfi et al.   Nature Communications

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis

(2017) So Maezawa et al.   NUCLEIC ACIDS RESEARCH

DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line

(2017) Elias ElInati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of protein disorder based on IUPred

(2017) Zsuzsanna Dosztányi   PROTEIN SCIENCE

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

(2017) Jun Ueda et al.   Cell Reports

Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction

(2017) Takashi Nakasuji et al.   PLoS Genetics

The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

(2017) Ofer Rog et al.   eLife

Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation

(2016) Stephen Gray et al.   Annual Review of Genetics

Mechanisms and Consequences of Macromolecular Phase Separation

(2016) Louis-Philippe Bergeron-Sandoval et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Phase separation in biology; functional organization of a higher order

(2016) Diana M. Mitrea et al.   Cell Communication and Signaling

Zfygenes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes

(2016) Nadège Vernet et al.   HUMAN MOLECULAR GENETICS

Structural organization of the inactive X chromosome in the mouse

(2016) Luca Giorgetti et al.   NATURE

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

(2016) H. Broder Schmidt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications

(2016) Kris G. Alavattam et al.   Cell Reports

Meiotic Silencing in Mammals

(2015) James M.A. Turner   Annual Review of Genetics

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Double-strand break repair on sex chromosomes: challenges during male meiotic prophase

(2015) Lin-Yu Lu et al.   CELL CYCLE

Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes

(2015) A. M. Fedoriw et al.   DEVELOPMENT

SCML2 Establishes the Male Germline Epigenome through Regulation of Histone H2A Ubiquitination

(2015) Kazuteru Hasegawa et al.   DEVELOPMENTAL CELL

FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis

(2015) Yasuko Kato et al.   HUMAN MOLECULAR GENETICS

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

Polycomb Protein SCML2 Associates with USP7 and Counteracts Histone H2A Ubiquitination in the XY Chromatin during Male Meiosis

(2015) Mengcheng Luo et al.   PLoS Genetics

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis

(2014) Tyler J. Broering et al.   JOURNAL OF CELL BIOLOGY

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase

(2014) V. V. Subramanian et al.   Cold Spring Harbor Perspectives in Biology

Mouse Y-Linked Zfy1 and Zfy2 Are Expressed during the Male-Specific Interphase between Meiosis I and Meiosis II and Promote the 2nd Meiotic Division

(2014) Nadège Vernet et al.   PLoS Genetics

Clamping down on mammalian meiosis

(2013) Amy Lyndaker et al.   CELL CYCLE

The great escape

(2013) Ho-Su Sin et al.   Epigenetics

ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing

(2013) H. Royo et al.   GENES & DEVELOPMENT

Meiotic Sex Chromosome Inactivation Is Disrupted in Sterile Hybrid Male House Mice

(2013) P. Campbell et al.   GENETICS

The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse

(2013) A. Vasileva et al.   JOURNAL OF CELL SCIENCE

Mechanistic basis of infertility of mouse intersubspecific hybrids

(2013) T. Bhattacharyya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the DNA damage response on male meiotic sex chromosomes

(2013) Lin-Yu Lu et al.   Nature Communications

Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance

(2013) Amy M. Lyndaker et al.   PLoS Genetics

Meiotic Cohesin SMC1β Provides Prophase I Centromeric Cohesion and Is Required for Multiple Synapsis-Associated Functions

(2013) Uddipta Biswas et al.   PLoS Genetics

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

(2013) Olivier J. Becherel et al.   PLoS Genetics

SPO11-Independent DNA Repair Foci and Their Role in Meiotic Silencing

(2013) Fabrizia Carofiglio et al.   PLoS Genetics

Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways

(2012) Yosuke Ichijima et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline

(2012) Andrew J. Modzelewski et al.   DEVELOPMENTAL CELL

RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids

(2012) H.-S. Sin et al.   GENES & DEVELOPMENT

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms

(2012) L. Wojtasz et al.   GENES & DEVELOPMENT

HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity

(2012) Hiroshi Kogo et al.   GENES TO CELLS

HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes

(2012) Hiroshi Kogo et al.   GENES TO CELLS

Human postmeiotic sex chromatin and its impact on sex chromosome evolution

(2012) H.-S. Sin et al.   GENOME RESEARCH

Homeostatic control of recombination is implemented progressively in mouse meiosis

(2012) Francesca Cole et al.   NATURE CELL BIOLOGY

Human Male Meiotic Sex Chromosome Inactivation

(2012) Marieke de Vries et al.   PLoS One

Phosphorylation of Chromosome Core Components May Serve as Axis Marks for the Status of Chromosomal Events during Mammalian Meiosis

(2012) Tomoyuki Fukuda et al.   PLoS Genetics

MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells

(2011) Y. Ichijima et al.   GENES & DEVELOPMENT

The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates

(2011) E. Refolio et al.   JOURNAL OF CELL SCIENCE

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1

(2011) Katrin Daniel et al.   NATURE CELL BIOLOGY

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis

(2011) J. Kim Holloway et al.   PLoS Genetics

Evidence that Meiotic Sex Chromosome Inactivation Is Essential for Male Fertility

(2010) Hélène Royo et al.   CURRENT BIOLOGY

Sex chromosome inactivation in the male

(2010) Wei Yan et al.   Epigenetics

DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis

(2010) Akiko Inagaki et al.   Epigenetics

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genetics of mammalian meiosis: regulation, dynamics and impact on fertility

(2010) Mary Ann Handel et al.   NATURE REVIEWS GENETICS

Chromosomal Redistribution of Male-Biased Genes in Mammalian Evolution with Two Bursts of Gene Gain on the X Chromosome

(2010) Yong E. Zhang et al.   PLOS BIOLOGY

Hormad1 Mutation Disrupts Synaptonemal Complex Formation, Recombination, and Chromosome Segregation in Mammalian Meiosis

(2010) Yong-Hyun Shin et al.   PLoS Genetics

Sumoylation precedes accumulation of phosphorylated H2AX on sex chromosomes during their meiotic inactivation

(2009) Margarita Vigodner   CHROMOSOME RESEARCH

BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes

(2009) A. Kouznetsova et al.   JOURNAL OF CELL SCIENCE

The consequences of asynapsis for mammalian meiosis

(2009) Paul S. Burgoyne et al.   NATURE REVIEWS GENETICS

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

A High Incidence of Meiotic Silencing of Unsynapsed Chromatin Is Not Associated with Substantial Pachytene Loss in Heterozygous Male Mice Carrying Multiple Simple Robertsonian Translocations

(2009) Marcia Manterola et al.   PLoS Genetics

Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

(2008) Shantha K. Mahadevaiah et al.   JOURNAL OF CELL BIOLOGY

Chromosomal Gene Movements Reflect the Recent Origin and Biology of Therian Sex Chromosomes

(2008) Lukasz Potrzebowski et al.   PLOS BIOLOGY