期刊
CELL REPORTS
卷 18, 期 3, 页码 593-600出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.12.065
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资金
- MEXT KAKENHI [JP26870343, JP16K07099, JP16H01319, JP15K18457, JP16H01219, JP16K18479, JP16H01577, JP16H01550, JP15H05976, JP25116005, JP25712035, JP25132709, JP25116010, JP25116002]
- Ministry of Education, Culture,Sports,Science and Technology (MEXT)
- Japan Agency for Medical Research and Development (AMED)
- Waseda Research Institute for Science and Engineering
- Chubu University Research Grants [27I M08B, 28I M09B]
- Takeda Science Foundation
- Research Fellowship of the Japan Society for the Promotion of Science for Young Scientists [JP15J06922, JP16J09361]
- Waseda University
- Grants-in-Aid for Scientific Research [16H01550, 16K18473, 25250014, 25712035, 16K18479, 15J06922, 16H01577, 16J09361, 17J06605, 25112007] Funding Source: KAKEN
Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-typespecific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia because of the loss of haploid germ cells. When differentiating spermatogonia emerge in normal spermatogenesis, H3t appears and replaces the canonical H3 proteins. Structural and biochemical analyses reveal that H3t-containing nucleosomes are more flexible than the canonical nucleosomes. Thus, by incorporating H3t into the genome during spermatogonial differentiation, male germ cells are able to enter meiosis and beyond.
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