Phase Separation during Germline Development

Phase separation organizes the site of autophagosome formation

(2020) Yuko Fujioka et al.   NATURE

Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

(2020) Chih-Yung S Lee et al.   eLife

Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties

(2020) Gregory L. Dignon et al.   Annual Review of Physical Chemistry

The Dynamics of P Granule Liquid Droplets Are Regulated by the Caenorhabditiselegans Germline RNA Helicase GLH-1 via Its ATP Hydrolysis Cycle

(2020) Wenjun Chen et al.   GENETICS

Multivalent weak interactions between assembly units drive synaptonemal complex formation

(2020) Zhenguo Zhang et al.   JOURNAL OF CELL BIOLOGY

Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters

(2020) Tatjana Trcek et al.   MOLECULAR CELL

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

(2020) Yan G. Zhao et al.   DEVELOPMENTAL CELL

Membraneless organelles: P granules in C. elegans

(2019) Elisabeth A. Marnik et al.   TRAFFIC

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

(2019) Lindsay B. Case et al.   SCIENCE

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aggregation, segregation, and dispersal of homotypic germ plasm RNPs in the early zebrafish embryo

(2019) Celeste Eno et al.   DEVELOPMENTAL DYNAMICS

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Acentriolar microtubule organization centers and Ran‐mediated microtubule formation pathways are both required in porcine oocytes

(2019) Yong‐Han Kim et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes

(2019) Chun So et al.   SCIENCE

Germ granules in Drosophila

(2019) Tatjana Trcek et al.   TRAFFIC

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation

(2019) Wilton T. Snead et al.   MOLECULAR CELL

Properties of Stress Granule and P-Body Proteomes

(2019) Ji-Young Youn et al.   MOLECULAR CELL

Mechanisms for Active Regulation of Biomolecular Condensates

(2019) Johannes Söding et al.   TRENDS IN CELL BIOLOGY

Chromosome-associated RNA–protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe

(2019) Da-Qiao Ding et al.   Nature Communications

Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules

(2018) Matthew G. Niepielko et al.   CURRENT BIOLOGY

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A liquid phase of synapsin and lipid vesicles

(2018) Dragomir Milovanovic et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli

(2018) Elliot Dine et al.   Cell Systems

mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation

(2018) Gangming Zhang et al.   CELL

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification

(2018) Elke F. Roovers et al.   DEVELOPMENTAL CELL

The P Granules of C. elegans: A Genetic Model for the Study of RNA–Protein Condensates

(2018) Geraldine Seydoux   JOURNAL OF MOLECULAR BIOLOGY

RNA polymerase II clustering through carboxy-terminal domain phase separation

(2018) Marc Boehning et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells

(2018) Kathryn E Kistler et al.   eLife

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2018) Dan Bracha et al.   CELL

Germ Granules Prevent Accumulation of Somatic Transcripts in the AdultCaenorhabditis elegansGermline

(2017) Andrew Kekūpa’a Knutson et al.   GENETICS

Error-prone meiotic division and subfertility in mice with oocyte-conditional knockdown of pericentrin

(2017) Claudia Baumann et al.   JOURNAL OF CELL SCIENCE

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles

(2017) Ming-Tzo Wei et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis

(2017) Divya Pattabiraman et al.   PLoS Genetics

Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning

(2017) Matias Escobar-Aguirre et al.   PLoS Genetics

Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.

(2017) Saravanapriah Nadarajan et al.   eLife

The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

(2017) Ofer Rog et al.   eLife

Germ Granules Prevent Accumulation of Somatic Transcripts in the AdultCaenorhabditis elegansGermline

(2017) Andrew Kekūpa’a Knutson et al.   GENETICS

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions

(2016) Adina Gerson-Gurwitz et al.   CELL

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

(2016) Shambaditya Saha et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

A Surveillance System Ensures Crossover Formation in C. elegans

(2016) Tyler S. Machovina et al.   CURRENT BIOLOGY

Proteomic Analysis of Mouse Oocytes Identifies PRMT7 as a Reprogramming Factor that Replaces SOX2 in the Induction of Pluripotent Stem Cells

(2016) Bingyuan Wang et al.   JOURNAL OF PROTEOME RESEARCH

Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm

(2016) Anastassios Vourekas et al.   NATURE

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

(2016) H. Broder Schmidt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

(2016) Jarrett Smith et al.   eLife

Distinct stages in stress granule assembly and disassembly

(2016) Joshua R Wheeler et al.   eLife

Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress

(2015) Edward W.J. Wallace et al.   CELL

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

CSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline

(2015) A. C. Campbell et al.   DEVELOPMENT

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Independent and coordinate trafficking of single Drosophila germ plasm mRNAs

(2015) Shawn C. Little et al.   NATURE CELL BIOLOGY

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Error-Prone Chromosome-Mediated Spindle Assembly Favors Chromosome Segregation Defects in Human Oocytes

(2015) Zuzana Holubcová et al.   OBSTETRICAL & GYNECOLOGICAL SURVEY

TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes

(2015) Mahdi Mahdipour et al.   PLoS One

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombination, Pairing, and Synapsis of Homologs during Meiosis

(2015) Denise Zickler et al.   Cold Spring Harbor Perspectives in Biology

Initiation of Meiotic Homologous Recombination: Flexibility, Impact of Histone Modifications, and Chromatin Remodeling

(2015) Lóránt Székvölgyi et al.   Cold Spring Harbor Perspectives in Biology

Drosophila germ granules are structured and contain homotypic mRNA clusters

(2015) Tatjana Trcek et al.   Nature Communications

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans

(2014) Jennifer T Wang et al.   eLife

Coordination of adjacent domains mediates TACC3–ch-TOG–clathrin assembly and mitotic spindle binding

(2013) Fiona E. Hood et al.   JOURNAL OF CELL BIOLOGY

Principles of PAR polarity in Caenorhabditis elegans embryos

(2013) Carsten Hoege et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Permeability of Reconstituted Nuclear Pores Provides Direct Evidence for the Selective Phase Model

(2012) Bastian B. Hülsmann et al.   CELL

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development

(2012) Aurélien Courtois et al.   JOURNAL OF CELL BIOLOGY

Spp1, a Member of the Set1 Complex, Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes

(2012) Vérane Sommermeyer et al.   MOLECULAR CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Meiosis-Specific Noncoding RNA Mediates Robust Pairing of Homologous Chromosomes in Meiosis

(2012) D.-Q. Ding et al.   SCIENCE

The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

(2012) L. Acquaviva et al.   SCIENCE

Full-Length Synaptonemal Complex Grows Continuously during Meiotic Prophase in Budding Yeast

(2012) Karen Voelkel-Meiman et al.   PLoS Genetics

Regulation of the MEX-5 Gradient by a Spatially Segregated Kinase/Phosphatase Cycle

(2011) Erik E. Griffin et al.   CELL

Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination

(2011) Silvia Panizza et al.   CELL

An Asymmetric Chromosome Pair Undergoes Synaptic Adjustment and Crossover Redistribution During Caenorhabditis elegans Meiosis: Implications for Sex Chromosome Evolution

(2011) J. V. Henzel et al.   GENETICS

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans

(2009) Yuxia Zhang et al.   CELL

Bucky Ball Organizes Germ Plasm Assembly in Zebrafish

(2009) Franck Bontems et al.   CURRENT BIOLOGY

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Bucky ball functions in Balbiani body assembly and animal–vegetal polarity in the oocyte and follicle cell layer in zebrafish

(2008) Florence L. Marlow et al.   DEVELOPMENTAL BIOLOGY