Phase separation in biology; functional organization of a higher order

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors

(2015) Sigrid Milles et al.   CELL

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition

(2015) Stephanie C. Weber et al.   CURRENT BIOLOGY

Relating sequence encoded information to form and function of intrinsically disordered proteins

(2015) Rahul K Das et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Free Energy Surface of an Intrinsically Disordered Protein: Comparison between Temperature Replica Exchange Molecular Dynamics and Bias-Exchange Metadynamics

(2015) Gül H. Zerze et al.   Journal of Chemical Theory and Computation

Structural Ensembles of Intrinsically Disordered Proteins Depend Strongly on Force Field: A Comparison to Experiment

(2015) Sarah Rauscher et al.   Journal of Chemical Theory and Computation

Molecular Dynamics Simulations of Intrinsically Disordered Proteins: Force Field Evaluation and Comparison with Experiment

(2015) João Henriques et al.   Journal of Chemical Theory and Computation

Multiscale enhanced sampling of intrinsically disordered protein conformations

(2015) Kuo Hao Lee et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Sequence- and Temperature-Dependent Properties of Unfolded and Disordered Proteins from Atomistic Simulations

(2015) Gül H. Zerze et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Kirkwood–Buff Approach Rescues Overcollapse of a Disordered Protein in Canonical Protein Force Fields

(2015) Davide Mercadante et al.   JOURNAL OF PHYSICAL CHEMISTRY B

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Encoding phase transitions

(2015) Alex S. Holehouse et al.   NATURE MATERIALS

Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers

(2015) Felipe García Quiroz et al.   NATURE MATERIALS

Correlated light and electron microscopy: ultrastructure lights up!

(2015) Pascal de Boer et al.   NATURE METHODS

Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells

(2015) Iwo König et al.   NATURE METHODS

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation

(2015) Mihwa Lee et al.   NUCLEIC ACIDS RESEARCH

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

(2015) Sudeep Banjade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of Ydj1 and Sis1 on Hsp70-mediated clearance of stress granules inSaccharomyces cerevisiae

(2015) Robert W. Walters et al.   RNA

Probing protein disorder and complexity at single-molecule resolution

(2015) Taehyung Lee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A matter of scale: how emerging technologies are redefining our view of chromosome architecture

(2015) Diego I. Cattoni et al.   TRENDS IN GENETICS

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

(2015) Hana Antonicka et al.   Cell Reports

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

(2015) Sonja Kroschwald et al.   eLife

Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering

(2015) Giancarlo Tria et al.   IUCrJ

In Vitro Reconstitution of a Cellular Phase-Transition Process that Involves the mRNA Decapping Machinery

(2014) Simon A. Fromm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

A Coarse-Grained Model for Polyglutamine Aggregation Modulated by Amphipathic Flanking Sequences

(2014) Kiersten M. Ruff et al.   BIOPHYSICAL JOURNAL

Single-Molecule Studies of Intrinsically Disordered Proteins

(2014) Marco Brucale et al.   CHEMICAL REVIEWS

Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division

(2014) A. Grob et al.   GENES & DEVELOPMENT

Accelerating the Conformational Sampling of Intrinsically Disordered Proteins

(2014) Trang Nhu Do et al.   Journal of Chemical Theory and Computation

Hamiltonian Switch Metropolis Monte Carlo Simulations for Improved Conformational Sampling of Intrinsically Disordered Regions Tethered to Ordered Domains of Proteins

(2014) Anuradha Mittal et al.   Journal of Chemical Theory and Computation

Balanced Protein–Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein Association

(2014) Robert B. Best et al.   Journal of Chemical Theory and Computation

Replica exchange with guided annealing for accelerated sampling of disordered protein conformations

(2014) Weihong Zhang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

NMR contributions to structural dynamics studies of intrinsically disordered proteins

(2014) Robert Konrat   JOURNAL OF MAGNETIC RESONANCE

Virus-like particles as antigenic nanomaterials for inducing protective immune responses in the lung

(2014) Agnieszka Rynda-Apple et al.   Nanomedicine

mRNP granules

(2014) J Ross Buchan   RNA Biology

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

(2013) Ilmin Kwon et al.   CELL

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Probing the stiffness of isolated nucleoli by atomic force microscopy

(2013) Emilie Louvet et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

The structure of the box C/D enzyme reveals regulation of RNA methylation

(2013) Audrone Lapinaite et al.   NATURE

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells

(2013) Marina Feric et al.   NATURE CELL BIOLOGY

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Seeds Higher-Order Assembly of FUS Protein

(2013) Jacob C. Schwartz et al.   Cell Reports

Characterization of disordered proteins with ENSEMBLE

(2012) Mickaël Krzeminski et al.   BIOINFORMATICS

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

RGG motif proteins: Modulators of mRNA functional states

(2012) Purusharth Rajyaguru et al.   CELL CYCLE

Structure and Dynamics of an Unfolded Protein Examined by Molecular Dynamics Simulation

(2012) Kresten Lindorff-Larsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles

(2012) Vidisha Tripathi et al.   MOLECULAR BIOLOGY OF THE CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation

(2012) D. M. Passon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a Molecular Theory of Early and Late Events in Monomer to Amyloid Fibril Formation

(2011) John E. Straub et al.   Annual Review of Physical Chemistry

Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering

(2011) Christopher B. Stanley et al.   BIOPHYSICAL JOURNAL

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

(2011) Simon A Fromm et al.   EMBO JOURNAL

Shuttling SR proteins: more than splicing factors

(2011) Laure Twyffels et al.   FEBS Journal

P granules extend the nuclear pore complex environment in theC. elegansgerm line

(2011) Dustin L. Updike et al.   JOURNAL OF CELL BIOLOGY

PGL proteins self associate and bind RNPs to mediate germ granule assembly inC. elegans

(2011) Momoyo Hanazawa et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation

(2011) Henna M. Moore et al.   MOLECULAR & CELLULAR PROTEOMICS

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Granules in Germ Cells

(2011) E. Voronina et al.   Cold Spring Harbor Perspectives in Biology

The traffic of proteins between nucleolar organizer regions and prenucleolar bodies governs the assembly of the nucleolus at exit of mitosis

(2011) Eleonora Muro et al.   Nucleus

Assembly and disassembly of the nucleolus during the cell cycle

(2011) Danièle Hernandez-Verdun   Nucleus

Small-angle neutron scattering and contrast variation: a powerful combination for studying biological structures

(2010) William T. Heller   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An introduction to NMR-based approaches for measuring protein dynamics

(2010) Ian R. Kleckner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

(2010) Joseph A. Marsh et al.   BIOPHYSICAL JOURNAL

Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs

(2010) Yuntao S. Mao et al.   NATURE CELL BIOLOGY

B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1

(2010) Z Yao et al.   ONCOGENE

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

The SR protein family

(2009) Peter J Shepard et al.   GENOME BIOLOGY

Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells

(2008) Mohammed Abdullahel Amin et al.   BIOCHEMICAL JOURNAL

Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos

(2008) Christopher M. Gallo et al.   DEVELOPMENTAL BIOLOGY

P bodies promote stress granule assembly inSaccharomyces cerevisiae

(2008) J. Ross Buchan et al.   JOURNAL OF CELL BIOLOGY

ABSINTH: A new continuum solvation model for simulations of polypeptides in aqueous solutions

(2008) Andreas Vitalis et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

NOPdb: Nucleolar Proteome Database--2008 update

(2008) Y. Ahmad et al.   NUCLEIC ACIDS RESEARCH