The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration

Structural Communication between the E. coli Chaperones DnaK and Hsp90

(2021) Matthew P. Grindle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hsp90 and its co‐chaperone Sti1 control TDP‐43 misfolding and toxicity

(2021) Lilian Tsai‐Wei Lin et al.   FASEB JOURNAL

Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

(2021) Marangelie Criado-Marrero et al.   Acta Neuropathologica Communications

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

(2020) Abhinav Joshi et al.   BMC BIOLOGY

STIP1/HOP Regulates the Actin Cytoskeleton through Interactions with Actin and Changes in Actin-Binding Proteins Cofilin and Profilin

(2020) Samantha Joy Beckley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mechanism of Hsp90-induced oligomerizaton of Tau

(2020) S. Weickert et al.   Science Advances

Hop depletion reduces HSF1 levels and activity and coincides with reduced stress resilience

(2020) Abantika Chakraborty et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The multiple functions of the co-chaperone stress inducible protein 1

(2020) Anna Carolina Carvalho da Fonseca et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Glucocorticoid receptor complexes form cooperatively with the Hsp90 co-chaperones Pp5 and FKBPs

(2020) Anna Kaziales et al.   Scientific Reports

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

(2020) John F. Darby et al.   Scientific Reports

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease

(2020) Rachel E. Lackie et al.   Acta Neuropathologica Communications

GOLPH3 Promotes Cancer Growth by Interacting With STIP1 and Regulating Telomerase Activity in Pancreatic Ductal Adenocarcinoma

(2020) Kebing Wang et al.   Frontiers in Oncology

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

(2020) Kaushik Bhattacharya et al.   Nature Communications

Assay design and development strategies for finding Hsp90 inhibitors and their role in human diseases

(2020) Monimoy Banerjee et al.   PHARMACOLOGY & THERAPEUTICS

Structure, Function, and Regulation of the Hsp90 Machinery

(2019) Maximilian M. Biebl et al.   Cold Spring Harbor Perspectives in Biology

The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity

(2019) Pablo C. Echeverria et al.   PLoS One

The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2

(2019) Florian H. Schopf et al.   MOLECULAR CELL

The ER chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation.

(2019) Ming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants

(2019) Marta Boysen et al.   MOLECULAR CELL

Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries

(2019) Vinay Dahiya et al.   MOLECULAR CELL

Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity

(2019) Fangke Xu et al.   Cell Reports

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stress-induced phosphoprotein 1 promotes pancreatic cancer progression through activation of the FAK/AKT/MMP signaling axis

(2019) Yuanming Jing et al.   PATHOLOGY RESEARCH AND PRACTICE

Hsp90 of E. coli modulates assembly of FtsZ, the bacterial tubulin homolog

(2019) Anuradha Balasubramanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co‐chaperone STI1

(2019) Rachel E. Lackie et al.   JOURNAL OF NEUROCHEMISTRY

Down-regulation of STIP1 regulate apoptosis and invasion of glioma cells via TRAP1/AKT signaling pathway

(2019) Hongwei Yin et al.   Cancer Genetics

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones

(2019) Salvatore Assenza et al.   eLife

Evidence for interaction between Hsp90 and the ER membrane complex

(2018) Tambudzai Kudze et al.   CELL STRESS & CHAPERONES

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

(2018) Len Neckers et al.   CELL STRESS & CHAPERONES

HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an Autocrine Fashion and Predicts Poor Survival in Gastric Cancer

(2018) Ertao Zhai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle

(2018) Michael Reidy et al.   GENETICS

Dancing with the Diva: Hsp90–Client Interactions

(2018) Martina Radli et al.   JOURNAL OF MOLECULAR BIOLOGY

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System

(2018) Tania Morán Luengo et al.   MOLECULAR CELL

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stress-induced phosphoprotein 1 mediates hepatocellular carcinoma metastasis after insufficient radiofrequency ablation

(2018) Tianhong Su et al.   ONCOGENE

Functional and physical interaction between yeast Hsp90 and Hsp70

(2018) Andrea N. Kravats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation

(2018) Ron Geller et al.   Nature Communications

Luminescence resonance energy transfer between genetically encoded donor and acceptor for protein-protein interaction studies in the molecular chaperone HSP70/HSP90 complexes

(2018) Kaushik Bhattacharya et al.   Scientific Reports

Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle

(2018) Michael Reidy et al.   GENETICS

Stress-induced phosphoprotein 1 acts as a scaffold protein for glycogen synthase kinase-3 beta-mediated phosphorylation of lysine-specific demethylase 1

(2018) Chia-Lung Tsai et al.   Oncogenesis

Hsp90 Mediates Membrane Deformation and Exosome Release

(2018) Elsa Lauwers et al.   MOLECULAR CELL

Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin

(2018) Sarah Naulikha Kituyi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

(2018) Sarah Kishinevsky et al.   Nature Communications

The Hsp70–Hsp90 Chaperone Cascade in Protein Folding

(2018) Tania Morán Luengo et al.   TRENDS IN CELL BIOLOGY

Interaction of E. coli Hsp90 with DnaK Involves the DnaJ Binding Region of DnaK

(2017) Andrea N. Kravats et al.   JOURNAL OF MOLECULAR BIOLOGY

The Plasticity of the Hsp90 Co-chaperone System

(2017) Priyanka Sahasrabudhe et al.   MOLECULAR CELL

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells

(2017) Lilian Cruz et al.   Stem Cell Reviews and Reports

Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells

(2017) Lilian Cruz et al.   Stem Cell Reviews and Reports

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature

(2016) Stacey A Mattison et al.   CELL STRESS & CHAPERONES

Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy

(2016) Longze Sha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate

(2016) Nuri Sung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes

(2016) Ima-obong Ebong et al.   Cell Discovery

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Plasmodium falciparum Hop: Detailed analysis on complex formation with Hsp70 and Hsp90

(2015) Rowan Hatherley et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hsp70 and Hsp90 of E. coli Directly Interact for Collaboration in Protein Remodeling

(2015) Olivier Genest et al.   JOURNAL OF MOLECULAR BIOLOGY

Methods to study chaperone-mediated autophagy

(2015) Bindi Patel et al.   METHODS

Hsp90: Breaking the Symmetry

(2015) Matthias P. Mayer et al.   MOLECULAR CELL

Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

(2015) Alina Röhl et al.   Nature Communications

Hsp90 can Accommodate the Simultaneous Binding of the FKBP52 and HOP Proteins

(2015) Zacariah L. Hildenbrand et al.   Oncotarget

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Hop/Sti1 phosphorylation inhibits its co-chaperone function

(2014) A. Rohl et al.   EMBO REPORTS

ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein (HOP)

(2014) Soh Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Assembly and Intermolecular Properties of the Hsp70-Tomm34-Hsp90 Molecular Chaperone Complex

(2014) Filip Trcka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Interaction between Bacterial Heat Shock Protein (Hsp) 90 and Hsp70 Chaperones Mediates Their Cooperative Action to Refold Denatured Proteins

(2014) Hitoshi Nakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 in cancer: back to the future

(2014) M Y Sherman et al.   ONCOGENE

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

(2014) Sara Alvira et al.   Nature Communications

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles

(2013) Glaucia N. M. Hajj et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains

(2013) Shin-Da Lee et al.   EMBO Molecular Medicine

Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein

(2013) Flavio H. Beraldo et al.   FASEB JOURNAL

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

The Prion Protein Ligand, Stress-Inducible Phosphoprotein 1, Regulates Amyloid-  Oligomer Toxicity

(2013) V. G. Ostapchenko et al.   JOURNAL OF NEUROSCIENCE

Regulation of Stress-Inducible Phosphoprotein 1 Nuclear Retention by Protein Inhibitor of Activated STAT PIAS1

(2013) Iaci N. Soares et al.   MOLECULAR & CELLULAR PROTEOMICS

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

(2013) Katie J. Wolfe et al.   MOLECULAR BIOLOGY OF THE CELL

Widespread Regulation of Translation by Elongation Pausing in Heat Shock

(2013) Reut Shalgi et al.   MOLECULAR CELL

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

(2013) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

Preface to Hsp90

(2012) Didier Picard   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines

(2012) Tarryn Willmer et al.   CANCER LETTERS

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

The Hsp90-Sti1 interaction is critical forLeishmania donovaniproliferation in both life cycle stages

(2012) Antje Hombach et al.   CELLULAR MICROBIOLOGY

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

(2012) Andreas B Schmid et al.   EMBO JOURNAL

Dynamics of the regulation of Hsp90 by the co-chaperone Sti1

(2012) Chung-Tien Lee et al.   EMBO JOURNAL

Global Analysis of Phosphoproteome Regulation by the Ser/Thr Phosphatase Ppt1 in Saccharomyces cerevisiae

(2012) Thiemo B. Schreiber et al.   JOURNAL OF PROTEOME RESEARCH

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

(2012) P Muller et al.   ONCOGENE

Regulation of Vascular Endothelial Cell Polarization and Migration by Hsp70/Hsp90-Organizing Protein

(2012) Jingyu Li et al.   PLoS One

HSP90 and the R2TP co-chaperone complex: Building multi-protein machineries essential for cell growth and gene expression

(2012) Séverine Boulon et al.   RNA Biology

Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells

(2012) Chia-Lung Tsai et al.   Cell Reports

The R2TP complex: Discovery and functions

(2011) Yoshito Kakihara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation

(2011) Naomi Walsh et al.   CANCER LETTERS

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

(2011) Surendra S. Ambegaokar et al.   HUMAN MOLECULAR GENETICS

Client-Loading Conformation of the Hsp90 Molecular Chaperone Revealed in the Cryo-EM Structure of the Human Hsp90:Hop Complex

(2011) Daniel R. Southworth et al.   MOLECULAR CELL

A Compound That Inhibits the HOP–Hsp90 Complex Formation and Has Unique Killing Effects in Breast Cancer Cell Lines

(2011) Genaro Pimienta et al.   MOLECULAR PHARMACEUTICS

An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

(2011) Pablo C. Echeverría et al.   PLoS One

Heterogeneity and dynamics in the assembly of the Heat Shock Protein 90 chaperone complexes

(2011) I.-o. Ebong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock protein 90 from Escherichia coli collaborates with the DnaK chaperone system in client protein remodeling

(2011) O. Genest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma

(2010) Hiroshi Kubota et al.   CELL STRESS & CHAPERONES

Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3

(2010) Shaoming Song et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sti1 Regulation of Hsp70 and Hsp90 Is Critical for Curing of Saccharomyces cerevisiae [PSI+] Prions by Hsp104

(2010) M. Reidy et al.   MOLECULAR AND CELLULAR BIOLOGY

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

(2010) Vamsi K Gangaraju et al.   NATURE GENETICS

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

(2010) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility

(2009) Pablo C. Echeverria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting HSP90 for cancer therapy

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90

(2009) Tommi Kajander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C. elegans STI-1, the Homolog of Sti1/Hop, Is Involved in Aging and Stress Response

(2009) Hyun-Ok Song et al.   JOURNAL OF MOLECULAR BIOLOGY

The Non-canonical Hop Protein from Caenorhabditis elegans Exerts Essential Functions and Forms Binary Complexes with Either Hsc70 or Hsp90

(2009) Andreas M. Gaiser et al.   JOURNAL OF MOLECULAR BIOLOGY

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

HOP is a monomer: Investigation of the oligomeric state of the co-chaperone HOP

(2009) Fang Yi et al.   PROTEIN SCIENCE

The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance inSaccharomyces cerevisiae

(2009) Stefan H. Millson et al.   YEAST

A Novel Class of Small Molecule Inhibitors of Hsp90

(2008) Fang Yi et al.   ACS Chemical Biology

Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock, and its proposed nuclear localization signal is involved in Hsp90 binding

(2008) Sheril Daniel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

(2008) J. L. Holmes et al.   CANCER RESEARCH

Structural Studies on the Co-chaperone Hop and Its Complexes with Hsp90

(2008) S.C. Onuoha et al.   JOURNAL OF MOLECULAR BIOLOGY

p23/Sba1p Protects against Hsp90 Inhibitors Independently of Its Intrinsic Chaperone Activity

(2008) F. Forafonov et al.   MOLECULAR AND CELLULAR BIOLOGY