HSP90 and the R2TP co-chaperone complex: Building multi-protein machineries essential for cell growth and gene expression

CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport

(2011) Bérengère Pradet-Balade et al.   EMBO JOURNAL

Iwr1 Directs RNA Polymerase II Nuclear Import

(2011) Elmar Czeko et al.   MOLECULAR CELL

Biogenesis of spliceosomal small nuclear ribonucleoproteins

(2011) Utz Fischer et al.   Wiley Interdisciplinary Reviews-RNA

New insights into the biogenesis of nuclear RNA polymerases?This paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

(2010) Philippe Cloutier et al.   Biochemistry and Cell Biology

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

(2010) H. Takai et al.   GENES & DEVELOPMENT

The Pih1-Tah1 Cochaperone Complex Inhibits Hsp90 Molecular Chaperone ATPase Activity

(2010) Kelvin Eckert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence

(2010) Ludovic Ménard et al.   JOURNAL OF HEPATOLOGY

Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal Cancer

(2010) Sara M. Johnson et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

The Protein Interaction Network of the Human Transcription Machinery Reveals a Role for the Conserved GTPase RPAP4/GPN1 and Microtubule Assembly in Nuclear Import and Biogenesis of RNA Polymerase II

(2010) Diane Forget et al.   MOLECULAR & CELLULAR PROTEOMICS

CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability

(2010) Zuzana Hořejší et al.   MOLECULAR CELL

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

(2010) Séverine Boulon et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcription of functionally related constitutive genes is not coordinated

(2010) Saumil J Gandhi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

(2010) S Whittaker et al.   ONCOGENE

AtNUFIP, an essential protein for plant development, reveals the impact of snoRNA gene organisation on the assembly of snoRNPs and rRNA methylation in Arabidopsis thaliana

(2010) Julie Rodor et al.   PLANT JOURNAL

AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

(2010) N. Izumi et al.   Science Signaling

Driving ribosome assembly

(2009) Dieter Kressler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting HSP90 for cancer therapy

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism

(2009) Valérie Haurie et al.   HEPATOLOGY

The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma

(2009) Ledu Zhou et al.   MEDICAL ONCOLOGY

RVB1/RVB2: Running Rings around Molecular Biology

(2009) Sudhakar Jha et al.   MOLECULAR CELL

Chaperone ligand-discrimination by the TPR-domain protein Tah1

(2008) Stefan H. Millson et al.   BIOCHEMICAL JOURNAL

Pontin and Reptin, Two Related ATPases with Multiple Roles in Cancer

(2008) O. Huber et al.   CANCER RESEARCH

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

(2008) Andrew S. Venteicher et al.   CELL

The post-transcriptional steps of eukaryotic ribosome biogenesis

(2008) A. K. Henras et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

(2008) Séverine Boulon et al.   JOURNAL OF CELL BIOLOGY

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

(2008) Rongmin Zhao et al.   JOURNAL OF CELL BIOLOGY

Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage

(2008) S. Jha et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of RNA Polymerase Assembly Dynamics in Transcriptional Regulation

(2008) Stanislaw A. Gorski et al.   MOLECULAR CELL

Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics

(2008) M. E. Sardiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA