Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

GSK-3β inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury

(2011) Xiaogang Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Controlling the cell cycle: The role of calcium/calmodulin-stimulated protein kinases I and II

(2011) Kathryn A. Skelding et al.   CELL CYCLE

Alzheimer’s Genetics in the GWAS Era: A Continuing Story of ‘Replications and Refutations’

(2011) Lars Bertram   Current Neurology and Neuroscience Reports

Double vision

(2011) Surendra S. Ambegaokar et al.   FLY

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1

(2011) Karli K. McDonald et al.   HUMAN MOLECULAR GENETICS

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAUP301L double-transgenic mice

(2011) Lili C. Kudo et al.   HUMAN MOLECULAR GENETICS

Direct Recruitment of ERK Cascade Components to Inducible Genes Is Regulated by Heterogeneous Nuclear Ribonucleoprotein (hnRNP) K

(2011) Michal Mikula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice

(2011) Frauke Glöckner et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells

(2011) M.J. Casarejos et al.   NEUROCHEMISTRY INTERNATIONAL

Function of Cytosolic Chaperones in Tom70-Mediated Mitochondrial Import

(2011) Anna C.Y. Fan et al.   PROTEIN AND PEPTIDE LETTERS

Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae

(2011) N. Gadir et al.   RNA

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins

(2010) Michinori Matsuo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Interaction Between Eye Pigment Genes and Tau-Induced Neurodegeneration in Drosophila melanogaster

(2010) Surendra S. Ambegaokar et al.   GENETICS

Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies

(2010) Tomás L. Falzone et al.   HUMAN MOLECULAR GENETICS

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy

(2010) Fiona M. Menzies et al.   HUMAN MOLECULAR GENETICS

A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism inDrosophila melanogasterphotoreceptors

(2010) W. Ryan Williamson et al.   JOURNAL OF CELL BIOLOGY

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

Aminopeptidases do not directly degrade tau protein

(2010) K Chow et al.   Molecular Neurodegeneration

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

(2010) K N Manolopoulos et al.   MOLECULAR PSYCHIATRY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

New evidences on Tau–DNA interactions and relevance to neurodegeneration

(2010) Vasudevaraju Padmaraju et al.   NEUROCHEMISTRY INTERNATIONAL

Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons

(2010) Qian Cai et al.   NEURON

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: A spectrum of TDP-43 proteinopathies

(2010) Felix Geser et al.   NEUROPATHOLOGY

Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease

(2010) J.-F. Ma et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

(2010) Vikram Khurana et al.   PLoS Genetics

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila

(2010) Ana Griciuc et al.   PLoS Genetics

Alzheimer’s disease: diagnostics, prognostics and the road to prevention

(2010) Iris Grossman et al.   EPMA Journal

FMR1: A gene with three faces

(2009) Ben A Oostra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondria in Huntington's disease

(2009) Maria Damiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and neurodegenerative diseases

(2009) Bo Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease

(2009) Rodrigo A. Quintanilla et al.   BRAIN RESEARCH BULLETIN

RETRACTED: Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas

(2009) Noriyuki Takai et al.   CANCER LETTERS

Novel Hsp90 partners discovered using complementary proteomic approaches

(2009) Pavel A. Tsaytler et al.   CELL STRESS & CHAPERONES

Patched regulates Smoothened trafficking using lipoprotein-derived lipids

(2009) H. Khaliullina et al.   DEVELOPMENT

Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines

(2009) Kazumichi M Nishida et al.   EMBO JOURNAL

A putative role for cell cycle-related proteins in microtubule-based neuroplasticity

(2009) Stefanie Schmetsdorf et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

(2009) James Folwell et al.   EXPERIMENTAL NEUROLOGY

hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP level during stress conditions

(2009) Toshiyuki Fukuda et al.   GENES TO CELLS

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Roles of Tom70 in Import of Presequence-containing Mitochondrial Proteins

(2009) Hayashi Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Familial FTDP-17 Missense Mutations Inhibit Microtubule Assembly-promoting Activity of Tau by Increasing Phosphorylation at Ser202in Vitro

(2009) Dong Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TorsinA and dystonia: from nuclear envelope to synapse

(2009) Alessandra Granata et al.   JOURNAL OF NEUROCHEMISTRY

Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects

(2009) T. L. Falzone et al.   JOURNAL OF NEUROSCIENCE

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice

(2009) Tomasz Jaworski et al.   PLoS One

Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy

(2009) K. Ohmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cadmium Toxicity toward Autophagy through ROS-Activated GSK-3β in Mesangial Cells

(2009) Sheng-Hao Wang et al.   TOXICOLOGICAL SCIENCES

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching

(2009) Yubing Lu et al.   Molecular Brain

Integrating Computational Biology and Forward Genetics in Drosophila

(2009) Stein Aerts et al.   PLoS Genetics

RNA Gain-of-Function in Spinocerebellar Ataxia Type 8

(2009) Randy S. Daughters et al.   PLoS Genetics

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2008) Masato Hasegawa et al.   ANNALS OF NEUROLOGY

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RNA-Binding Protein Hoip Accelerates PolyQ-Induced Neurodegeneration inDrosophila

(2008) Takuya MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Calmodulin-dependent kinase 1β is expressed in the epiphyseal growth plate and regulates proliferation of mouse calvarial osteoblasts in vitro

(2008) Mona E. Pedersen et al.   BONE

The Homotetrameric Kinesin-5 KLP61F Preferentially Crosslinks Microtubules into Antiparallel Orientations

(2008) Siet M.J.L. van den Wildenberg et al.   CURRENT BIOLOGY

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

ALS and FTLD: two faces of TDP-43 proteinopathy

(2008) R. M. Liscic et al.   EUROPEAN JOURNAL OF NEUROLOGY

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Dissociation of tau toxicity and phosphorylation: role of GSK-3β, MARK and Cdk5 in a Drosophila model

(2008) Shreyasi Chatterjee et al.   HUMAN MOLECULAR GENETICS

Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP

(2008) Bastian Linder et al.   HUMAN MOLECULAR GENETICS

Golgi apparatus and neurodegenerative diseases

(2008) Jie Fan et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Glycogen Synthase Kinase (GSK) 3β Directly Phosphorylates Serine 212 in the Regulatory Loop and Inhibits Microtubule Affinity-regulating Kinase (MARK) 2

(2008) Thomas Timm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth

(2008) Tadayuki Shimada et al.   JOURNAL OF CELL BIOLOGY

The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila

(2008) N. Vereshchagina et al.   JOURNAL OF CELL SCIENCE

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats

(2008) Selina Wray et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons

(2008) Patricia S. Estes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

(2008) Ling-Bo Li et al.   NATURE

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

(2008) Gary J. Bassell et al.   NEURON

Binding to the Minor Groove of the Double-Strand, Tau Protein Prevents DNA from Damage by Peroxidation

(2008) Yan Wei et al.   PLoS One

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Tuning Microtubule-Based Transport Through Filamentous MAPs: The Problem of Dynein

(2008) Michael Vershinin et al.   TRAFFIC

Dynamic endogenous association of neurofilament mRNAs with K-homology domain ribonucleoproteins in developing cerebral cortex

(2007) Amar Thyagarajan et al.   BRAIN RESEARCH

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL

Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation

(2007) Anna Bersano et al.   NEUROBIOLOGY OF AGING

p38 Kinase Is Activated in the Alzheimer's Disease Brain

(2003) Kenneth Hensley et al.   JOURNAL OF NEUROCHEMISTRY