TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain

Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.

(2020) Jennifer A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

The fibroblast-derived protein PI16 controls neuropathic pain

(2020) Pooja Singhmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

(2020) Uddalak Bharadwaj et al.   PHARMACOLOGICAL REVIEWS

Interactive Peptide Spectral Annotator: A Versatile Web-Based Tool for Proteomic Applications

(2019) Dain R. Brademan et al.   MOLECULAR & CELLULAR PROTEOMICS

Chemotherapy-induced peripheral neuropathy

(2019) Lesley A. Colvin   PAIN

Cell-specific role of HDAC6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers

(2019) Jiacheng Ma et al.   PAIN

Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source

(2018) Jiacheng Ma et al.   CANCER

Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation

(2018) Lorenzo Di Cesare Mannelli et al.   NEUROPHARMACOLOGY

Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

(2018) Moses Kasembeli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice

(2018) Gabriel S. Chiu et al.   Oncotarget

The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice

(2017) Niharika Amireddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of STAT3-mediated CXCL12 up-regulation in the dorsal root ganglion contributes to oxaliplatin-induced chronic pain

(2017) Yong-Yong Li et al.   Molecular Pain

Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics–induced neuropathic pain

(2017) Ting Xu et al.   PAIN

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

(2017) Karen Krukowski et al.   PAIN

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

(2017) Davide Genini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

(2017) Magdalena A. Maj et al.   Frontiers in Molecular Neuroscience

Mitochondrial Stat3, the Need for Design Thinking

(2016) Rui Yang et al.   International Journal of Biological Sciences

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

(2016) Uddalak Bharadwaj et al.   Oncotarget

Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent

(2016) Daniel P. Ball et al.   Oncotarget

Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII–CREB and Astroglial JAK2–STAT3 Cascades in Mice

(2015) Shenbin Liu et al.   ANESTHESIOLOGY

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain

(2015) Deepitha Selvaraj et al.   CANCER CELL

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies

(2015) Michinori Ogura et al.   CANCER SCIENCE

A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3

(2015) Daniel J. Garama et al.   MOLECULAR AND CELLULAR BIOLOGY

SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth

(2015) Ye Sun et al.   Science Signaling

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

(2015) Yuta Kohro et al.   Scientific Reports

SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth

(2015) Ye Sun et al.   Science Signaling

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

(2014) Johanna C. Bendell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

(2014) Qi-Liang Mao-Ying et al.   PLoS One

Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy

(2012) An Verheyen et al.   BRAIN

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

(2009) Xuejun Xu et al.   PLoS One

JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat

(2008) Elisa Dominguez et al.   JOURNAL OF NEUROCHEMISTRY