TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain
Authors
Keywords
STAT3, neuropathic pain, allodynia, CIPN, TTI-101, VEGF
Journal
BIOCHEMICAL PHARMACOLOGY
Volume 192, Issue -, Pages 114688
Publisher
Elsevier BV
Online
2021-07-16
DOI
10.1016/j.bcp.2021.114688
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.
- (2020) Jennifer A. Ward et al. JOURNAL OF MEDICINAL CHEMISTRY
- The fibroblast-derived protein PI16 controls neuropathic pain
- (2020) Pooja Singhmar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
- (2020) Uddalak Bharadwaj et al. PHARMACOLOGICAL REVIEWS
- Interactive Peptide Spectral Annotator: A Versatile Web-Based Tool for Proteomic Applications
- (2019) Dain R. Brademan et al. MOLECULAR & CELLULAR PROTEOMICS
- Chemotherapy-induced peripheral neuropathy
- (2019) Lesley A. Colvin PAIN
- Cell-specific role of HDAC6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers
- (2019) Jiacheng Ma et al. PAIN
- Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source
- (2018) Jiacheng Ma et al. CANCER
- Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation
- (2018) Lorenzo Di Cesare Mannelli et al. NEUROPHARMACOLOGY
- Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
- (2018) Moses Kasembeli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice
- (2018) Gabriel S. Chiu et al. Oncotarget
- The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice
- (2017) Niharika Amireddy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of STAT3-mediated CXCL12 up-regulation in the dorsal root ganglion contributes to oxaliplatin-induced chronic pain
- (2017) Yong-Yong Li et al. Molecular Pain
- Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics–induced neuropathic pain
- (2017) Ting Xu et al. PAIN
- HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy
- (2017) Karen Krukowski et al. PAIN
- Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells
- (2017) Davide Genini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy
- (2017) Magdalena A. Maj et al. Frontiers in Molecular Neuroscience
- Mitochondrial Stat3, the Need for Design Thinking
- (2016) Rui Yang et al. International Journal of Biological Sciences
- The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
- (2016) Stefka Tyanova et al. Nature Protocols
- Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
- (2016) Uddalak Bharadwaj et al. Oncotarget
- Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent
- (2016) Daniel P. Ball et al. Oncotarget
- Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII–CREB and Astroglial JAK2–STAT3 Cascades in Mice
- (2015) Shenbin Liu et al. ANESTHESIOLOGY
- A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain
- (2015) Deepitha Selvaraj et al. CANCER CELL
- Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies
- (2015) Michinori Ogura et al. CANCER SCIENCE
- A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3
- (2015) Daniel J. Garama et al. MOLECULAR AND CELLULAR BIOLOGY
- SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth
- (2015) Ye Sun et al. Science Signaling
- A new minimally-invasive method for microinjection into the mouse spinal dorsal horn
- (2015) Yuta Kohro et al. Scientific Reports
- SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth
- (2015) Ye Sun et al. Science Signaling
- Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors
- (2014) Johanna C. Bendell et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model
- (2014) Qi-Liang Mao-Ying et al. PLoS One
- Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy
- (2012) An Verheyen et al. BRAIN
- Assessing mitochondrial dysfunction in cells
- (2011) Martin D. Brand et al. BIOCHEMICAL JOURNAL
- JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats
- (2011) Makoto Tsuda et al. BRAIN
- Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
- (2010) Carol Kilkenny et al. PLOS BIOLOGY
- Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation
- (2009) Xuejun Xu et al. PLoS One
- JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat
- (2008) Elisa Dominguez et al. JOURNAL OF NEUROCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More