Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function

(2016) Gabriel S. Chiu et al.   CANCER RESEARCH

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

(2016) Pooja Singhmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change

(2015) Eun-Joo Shin et al.   MOLECULAR NEUROBIOLOGY

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ

(2015) Karen Krukowski et al.   PAIN

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

(2014) Gary J. Bennett et al.   Nature Reviews Neurology

Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer

(2014) LIANG MA et al.   ONCOLOGY REPORTS

Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

(2014) Marta Seretny et al.   PAIN

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

(2014) Qi-Liang Mao-Ying et al.   PLoS One

Impulse Conduction Increases Mitochondrial Transport in Adult Mammalian Peripheral Nerves In Vivo

(2014) Marija Sajic et al.   PLOS BIOLOGY

Oxidative stress and nerve damage: Role in chemotherapy induced peripheral neuropathy

(2014) Aparna Areti et al.   Redox Biology

p53 protein subcellular localization and apoptosis in rodent corneal epithelium cell culture following ultraviolet irradiation

(2013) YEVGENY TENDLER et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Does Chemotherapy Really Affect the Quality of Life of Women with Breast Cancer?

(2013) Sook Yeon Hwang et al.   Journal of Breast Cancer

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

(2013) Huijing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The HSP70 and Autophagy Inhibitor Pifithrin-  Enhances the Antitumor Effects of TRAIL on Human Pancreatic Cancer

(2013) H. Monma et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage

(2013) Cora H. Nijboer et al.   NEUROBIOLOGY OF DISEASE

Pifithrin-μ, an Inhibitor of Heat-Shock Protein 70, Can Increase the Antitumor Effects of Hyperthermia Against Human Prostate Cancer Cells

(2013) Kazumasa Sekihara et al.   PLoS One

Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine

(2012) Jessica A. Boyette-Davis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Direct Induction of Apoptosis Using an Optimal Mitochondrially Targeted p53

(2012) Mohanad Mossalam et al.   MOLECULAR PHARMACEUTICS

The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA

(2012) Sherry L. Wolf et al.   SUPPORTIVE CARE IN CANCER

Targeting the p53 pathway to protect the neonatal ischemic brain

(2011) Cora H. Nijboer et al.   ANNALS OF NEUROLOGY

Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline

(2011) J. Boyette-Davis et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat

(2011) W.H. Xiao et al.   NEUROSCIENCE

Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel

(2011) W.H. Xiao et al.   NEUROSCIENCE

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia

(2011) M Kaiser et al.   Blood Cancer Journal

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

The Role of Oxidative Stress and Anti-Oxidant Treatment in Platinum-Induced Peripheral Neurotoxicity

(2010) V. A. Carozzi et al.   CURRENT CANCER DRUG TARGETS

Regulation of Mitochondrial Apoptotic Events by p53-mediated Disruption of Complexes between Antiapoptotic Bcl-2 Members and Bim

(2010) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Vanilloid 1 is Essential for Cisplatin-Induced Heat Hyperalgesia in Mice

(2010) Lauren E Ta et al.   Molecular Pain

Cisplatin induced Mitochondrial DNA damage in dorsal root ganglion neurons

(2010) Jewel L. Podratz et al.   NEUROBIOLOGY OF DISEASE

Assessment of Cancer-Related Neuropathy and Neuropathic Pain

(2010) C. S. Cleeland et al.   ONCOLOGIST

Cytoplasmic p53 and Activated Bax Regulate p53-dependent, Transcription-independent Neural Precursor Cell Apoptosis

(2009) Ying Geng et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Implications of Apurinic/Apyrimidinic Endonuclease in Reactive Oxygen Signaling Response after Cisplatin Treatment of Dorsal Root Ganglion Neurons

(2008) Y. Jiang et al.   CANCER RESEARCH

Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy

(2008) Giorgia Melli et al.   EXPERIMENTAL NEUROLOGY

Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-l-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells

(2007) Hai Wei Jin et al.   EXPERIMENTAL NEUROLOGY